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Wax screen printing processing method for cloth-based microfluidic analytical chip

A technology for microfluidic analysis and processing methods, which is applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc. Analyze the problems of chips, difficult high-throughput, high-resolution chip processing, etc., to achieve the effects of simple instrument operation, high resolution, and high utilization efficiency

Active Publication Date: 2014-12-24
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The processing method of the cloth-based microfluidic analysis chip can locate the detection area more accurately, but there are still some defects: (1) The pattern model on the wax paper needs to be carved or cut manually, so it is difficult to obtain a hydrophilic channel with precise size , and it is difficult to make a microfluidic analysis chip with a complex flow path; (2) There is a problem of transfer efficiency when the wax is transferred from paper to cloth
The transfer efficiency is subject to many factors (such as paper type, degree of contact between paper and cloth, temperature, etc.), so this processing method has high requirements for paper, cloth and even operating conditions; (3) Finally, this processing method is difficult to carry out High-throughput, high-resolution chip processing

Method used

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  • Wax screen printing processing method for cloth-based microfluidic analytical chip
  • Wax screen printing processing method for cloth-based microfluidic analytical chip
  • Wax screen printing processing method for cloth-based microfluidic analytical chip

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A wax screen printing processing method for a cloth-based microfluidic analysis chip (there are 3 shapes in the hydrophilic region), comprising the following steps:

[0043] 1) Take about 0.8 square meters of cotton cloth and put it in a beaker, add 500mL of ultrapure water, and then boil it in a water bath at a temperature of 95°C for 5 minutes;

[0044] 2) Take out the cotton cloth after boiling, put the cotton cloth in another beaker after the water drips dry, add 500mL of sodium carbonate solution with a concentration of 10mg / mL, and soak for 5min;

[0045] 3) After soaking in sodium carbonate solution, rinse with water until the pH value of the cotton cloth is 6, and dry at room temperature for 2 hours; the normal pH value of human urine is about 6, which is weakly acidic. Rinsing until the pH value of the cotton cloth is 6 is to ensure that there will be no great interference in the later biochemical detection.

[0046] 4) The treated cotton cloth is laid flat on...

Embodiment 2

[0050] Wax screen printing processing method for high-throughput cloth-based microfluidic analysis chips

[0051] 1. Use the software Adobe Illustrate CS5 to design the screen pattern such as image 3 As shown, the black in the pattern means that the wax can pass through the screen, and the white means that the wax cannot pass through the screen. On a rectangular canvas with width and height of 160mm and 120mm respectively, two circular arrays of different sizes are designed. One type of array has a circle diameter of 8mm arranged in 4 rows and 12 columns; the other array has a circle diameter of 10mm arranged in 4 rows and 9 columns.

[0052] 2. The stencil made according to the stencil design pattern is as follows: Figure 4 As shown, the dark color in the stencil represents the part where the wax cannot pass through, corresponding to the formation of a hydrophilic region on the cotton substrate; the light color represents the part that the wax can pass through, correspond...

Embodiment 3

[0056] Resolution of hydrophilic channel of bucky microfluidic analysis chip

[0057] Such as Figure 6 As shown, the designed width of the hydrophilic channel of the cloth-based microfluidic analysis chip changes from 0.9mm to 2.5mm (incrementally increasing by 0.2mm). When the melting temperature and heating time were 75℃ and 5s, respectively, the carmine dye solution could fill the hydrophilic channel with a designed width greater than 1.9mm. However, when the melting temperature remains constant, the carmine dye solution cannot be successfully filled even in the hydrophilic channel with the largest designed width (2.5 mm) only by increasing the heating time to 10 s and 15 s. Therefore, the minimum width of the hydrophilic channel of the cloth-based microfluidic analysis chip processed by wax screen printing can reach 1.9mm. After the wax on the surface of the cotton cloth is heated and melted, it not only penetrates vertically into the cotton cloth, but also spreads to t...

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Abstract

The invention discloses a wax screen printing processing method for a cloth-based microfluidic analytical chip. The method comprises the following steps: placing cotton cloth in a container, adding water to the container and boiling; taking out the cotton cloth, drying the moisture, placing the dried cotton cloth in another container, and adding a sodium carbonate solution to soak the cotton cloth; taking out the cotton cloth, washing the cloth with water and drying; flattening the processed cotton cloth on a platform, covering a screen printing board with a designed pattern on the cotton cloth, waxing and milling; roasting the screen board and the cotton cloth together; after roasting, separating the cotton cloth from the screen board to obtain the cloth-based microfluidic analytical chip. The method disclosed by the invention is to directly coat the wax on the cotton cloth through the screen board, and then heat and fuse the wax to penetrate in the cotton cloth without other media to transfer, so that the utilization efficiency of the wax is high and the utilization effect is good. In addition, the chip prepared by the method has the characteristics of high flux and high resolution.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chip processing, and in particular relates to a wax screen printing processing method for a cloth-based microfluidic analysis chip. Background technique [0002] In recent years, the development of microfluidic analysis chip technology has been very rapid. It was initially applied in chemical related fields, and later introduced into the fields of biology and medicine. Now it is a new field spanning chemistry, biology, medicine, physics and other multidisciplinary fields. It has a good development prospect and is of great significance to the development of medical detection technology in the whole society. More importantly, in order to improve the level of medical technology in areas with poor resources and relatively backward economy, there is an urgent need for people to research microfluidic analysis chips with low cost, light weight, simple operation, strong stability, short detection cyc...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 章春笋刘敏
Owner SOUTH CHINA NORMAL UNIVERSITY
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