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New Application of Total Alkaloids of Shujincao

A technology of total alkaloids and Shujincao, which is applied in the application field of medicine, can solve the problems that the research on the pharmacological active ingredients of Shujincao has not yet been reported.

Active Publication Date: 2018-06-19
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, studies on pharmacologically active ingredients related to the expelling wind and dampness of Shujincao have not been reported.

Method used

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  • New Application of Total Alkaloids of Shujincao
  • New Application of Total Alkaloids of Shujincao
  • New Application of Total Alkaloids of Shujincao

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1. The preparation of the total alkaloids of Shujincao

[0023] Take 1kg of Shujincao crude drug, add 8L of 1% HCl aqueous solution (solid-to-liquid ratio 1:8) and heat at 80°C for three times. The extracts were combined, filtered, concentrated to 5 L under reduced pressure, an appropriate amount of 2% NaOH solution was added to adjust the pH to 9, and then extracted three times with 2 L of dichloromethane. The dichloromethane layers were combined, and the solvent was recovered to dryness to obtain the total alkaloids of Shujincao.

Embodiment 2

[0024] Example 2. The effect of total alkaloids of vine stone pine on arthritis rats induced by complete Freund's adjuvant

[0025] (1) Experimental method

[0026] Rats are divided into five groups, i.e. normal group, model group, positive drug group (diclofenac sodium 10mg / kg), the high-dose group (40mg / kg) of total alkaloids of Shujincao prepared in embodiment 1 and embodiment 1 The prepared Shujincao total alkaloid low dose group (20mg / kg). Inflammation was induced by intradermal injection of complete Freund's adjuvant in the right hind paw of rats (except normal group). From the second day of inflammation, the drug was given by intragastric administration once a day for 28 days. The degree of swelling and arthritis index of rats' inflamed lateral paws were evaluated on the 7th day, 14th day, 21st day and 28th day of administration, respectively. After 28 days of administration, blood was collected under anesthesia, and peripheral blood lymphocytes and neutrophils were ...

Embodiment 3

[0053] Take 1kg of Shujincao crude drug, add 5L of 2% HCl aqueous solution at 70°C and heat for extraction 4 times. The extracts were combined, filtered, concentrated under reduced pressure to 4 L, and an appropriate amount of 5% NaOH solution was added to adjust the pH value to 10, followed by extraction with 2 L of dichloromethane for 4 times. The dichloromethane layers were combined, and the solvent was recovered to dryness to obtain the total alkaloids of Shujincao.

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PUM

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Abstract

The invention provides novel application of beefwood-like clubmoss herb total alkaloids to treatment of rheumatoid arthritis and a drug composition of beefwood-like clubmoss herb total alkaloids. Beefwood-like clubmoss herb total alkaloids are lycopodium alkaloids extracted from beefwood-like clubmoss herb in general and have a certain treatment effect in the experiment of a rat arthritis model induced by a complete Freund's adjuvant, so that beefwood-like clubmoss herb total alkaloids have a definite anti-rheumatoid arthritis effect and can be combined with auxiliary materials to prepare anti-rheumatoid arthritis drugs.

Description

technical field [0001] The invention relates to the medical use of active ingredients extracted from Chinese herbal medicines, in particular to the application of the total alkaloids of Shujincao in the preparation of medicines for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is an autoimmune disease characterized by synovitis and chronic polyarthritis as the main clinical manifestation. In the late stage, it can cause joint deformities, eventually lead to varying degrees of disability, and even involve the heart, lungs, Kidney and other functions seriously affect human health. There are three categories of drugs traditionally used to treat RA clinically, namely non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), and glucocorticoids. In recent years, the academic community has increasingly recognized that early combination therapy with DMARDs and NSAIDs or glucocorticoids is an i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/11A61P29/00A61P19/02
CPCA61K9/2059A61K36/11A61K2236/33A61K2236/35A61K2236/51
Inventor 潘珂
Owner CHINA PHARM UNIV