Liquid cooling dropping pill production line

A technology of cold dripping pills and production lines, which is applied in the direction of making medicines into special physical or taking forms of devices, etc., can solve the problem of unsatisfactory effect of dripping small pills or large pills, large differences in the size of the pill weight, large size difference of the equipment, etc. Large and other problems, to achieve the effect of widening the diameter range, eliminating surging and pulse, and reducing energy consumption

Inactive Publication Date: 2015-01-14
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The dripping pill machine that produces on the market basically all adopts natural dripping system at present, or the pressurized dripping system that is improved by the natural dripping system method, no matter adopts which dripping system, all there is following shortcoming: 1, natural gravity or pressure Dropping, relying on the surface tension and internal stress of the liquid to form pills by itself, the frequency of dropping is low, the roundness is not enough, and the weight and size of the pills are quite different; The effect of large pills is not ideal; 3. When the equipment adjusts the output, generally it can only be adjusted by changing the dripper and pressure, the dripping frequency is low, the energy consumption is large, and the equipment volume is large

Method used

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  • Liquid cooling dropping pill production line
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  • Liquid cooling dropping pill production line

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Preparation of Compound Danshen Dripping Pills

[0040] Get 600g of Danshen Sanqi extract, 5g of borneol, and 2000g of PEG-6000 (polyethylene glycol-6000) auxiliary material. First add PEG-6000 into the chemical material tank 100, heat it to 90°C, melt it in advance, then add the extract of Danshen Panax notoginseng, and mix evenly to form a liquid. Adjust the vibration frequency of the pneumatic vibrating dripper 200 to 50Hz, the dripping speed to 10Kg / hr, the dripping acceleration to 4.5G, and the dripping pressure to 1.8Bar. The heat preservation chamber 210 is insulated with an electric heating jacket, and the temperature of the dripper is controlled at 85°C. Observe the shape of the dropping pills with the naked eye through the strobe light. The size and shape of a single dropping pill are moderate, and there is no adhesion between the upper and lower dropping pills, and the normal dripping system continues to be maintained. The heating temperature of...

Embodiment 2

[0041] Embodiment two preparation Danshen dripping pills

[0042] Take 600g of salvia miltiorrhiza extract, add 60g of water, add 1500g of PEG-6000 auxiliary material, put it into a chemical tank and heat to 90°C, make it melt completely and mix evenly into a liquid. The liquid medicine is transported to the dripper under pressure, the dripping vibration frequency is 90Hz, the dripping speed is 40Kg / hr, the dripping acceleration is 20G, and the dripping pressure is 4Bar. Infrared heating is used for heat preservation, and the dripping temperature is controlled at 100°C. Observe the shape of the dropping pills through the strobe light and the camera, compare the shape of the dropping pills captured by the camera with the preset standard shape of the dropping pills, and find that the distance between the upper and lower dropping pills is too close and there is adhesion, reduce the dripping pressure to 3Bar, vibration frequency 140Hz, dripping speed 12Kg / hr, and continue to obser...

Embodiment 3

[0043] Embodiment three preparation Huoxiangzhengqi dripping pills

[0044] Take Huoxiangzhengqi Extract 200g, Patchouli Oil 1ml, Perilla Leaf Oil 2ml, Polyethylene Glycol 600g, add it into the chemical tank at the same time, heat to 65-85°C, melt, mix evenly to form a liquid. The medicinal liquid is introduced into the buffer tank, then sent to the dripper by pressurizing the buffer tank, and drips out from the bottom of the dripper into the cooling tank. Adjust the vibration frequency of the electric vibrating dripper to 200Hz, the dripping speed to 30Kg / hr, the dripping acceleration to 10G, and the dripping pressure to 0.5Bar. Observe the shape of the droplet with the naked eye through the strobe light, and find that the volume of the cutting droplet is too large, adjust and increase the vibration frequency to 300Hz to reduce the volume of the cutting droplet; adjust and increase the vibration acceleration to 10G to increase the shear force of the droplet , the dropping sp...

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Abstract

The invention provides a liquid cooling dropping pill production line, which comprises a dropping pill system, a liquid cooling circulation system and a control system, wherein the dropping pill system comprises a material melting tank and a dropper connected with the material melting tank, a vibration device is arranged between the material melting tank and the dropper, an on-line monitoring device is arranged on the dropper, the on-line monitoring device comprises a pulse signal emitting mechanism, the emitting frequency of the pulse signal emitting mechanism is identical to the vibration frequency of the vibration device, and the control system controls and regulates dropping parameters according to the monitoring results of the on-line monitoring device. The liquid cooling dropping pill production line has the advantages that the high-frequency cutting dropping is combined, the dropping pill quality is detected in real time on line and is controlled and regulated, the yield is improved, and the drilling pill diameter range is expanded; a plurality of tangential inlets are formed inside the tank wall of a cooling tank, and the impact force caused by cooling liquid surface on liquid drips when the liquid drips enter the cooling tank can be effectively reduced; the swarming and the pulse can be effectively eliminated, so the material conveying of a dropping pill machine is stable; the dropping pill cooling time is increased through regulating the length-to-diameter ratio of a discharging pipeline, the quality is ensured, and meanwhile, the energy consumption is reduced.

Description

technical field [0001] The invention relates to a liquid-cooled dropping pill production line, which belongs to the technical field of dropping pill production line manufacturing. Background technique [0002] Dropping pills are the traditional dosage form of traditional Chinese medicine preparations. Its advantages are short production cycle and no dust pollution; high bioavailability, rapid onset and long-term effect of local administration; it can reduce drug volatilization and increase drug stability; Easy to carry and store. [0003] The dripping pill machine that produces on the market basically all adopts natural dripping system at present, or the pressurized dripping system that improves by natural dripping system method, no matter adopts which dripping system, all there is following shortcoming: 1, natural gravity or pressure Dropping, relying on the surface tension and internal stress of the liquid to form pills by itself, the frequency of dropping is low, the rou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/06
Inventor 闫希军孙小兵郑永锋范立君付艳
Owner TIANJIN TASLY PHARMA CO LTD
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