The invention provides a liquid cooling dropping pill production line, which comprises a dropping pill system, a liquid cooling circulation system and a control system, wherein the dropping pill system comprises a material melting tank and a dropper connected with the material melting tank, a vibration device is arranged between the material melting tank and the dropper, an on-line monitoring device is arranged on the dropper, the on-line monitoring device comprises a pulse signal emitting mechanism, the emitting frequency of the pulse signal emitting mechanism is identical to the vibration frequency of the vibration device, and the control system controls and regulates dropping parameters according to the monitoring results of the on-line monitoring device. The liquid cooling dropping pill production line has the advantages that the high-frequency cutting dropping is combined, the dropping pill quality is detected in real time on line and is controlled and regulated, the yield is improved, and the drilling pill diameter range is expanded; a plurality of tangential inlets are formed inside the tank wall of a cooling tank, and the impact force caused by cooling liquid surface on liquid drips when the liquid drips enter the cooling tank can be effectively reduced; the swarming and the pulse can be effectively eliminated, so the material conveying of a dropping pill machine is stable; the dropping pill cooling time is increased through regulating the length-to-diameter ratio of a discharging pipeline, the quality is ensured, and meanwhile, the energy consumption is reduced.