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Geranium oil and constituents thereof for treatment of neurodegenerative diseases

A technology of neurodegeneration and active ingredients, applied in nervous system diseases, organic active ingredients, active ingredients of hydroxyl compounds, etc., can solve problems such as lack of cholinergic neurotransmitters, cognitive decline, and lack

Inactive Publication Date: 2015-01-14
以色列国家农业和农村发展部农业科研组织(ARO)(沃尔卡尼中心)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These observations form the cholinergic hypothesis of Alzheimer's disease (Bartus et al., Science. 1982 Jul 30; 217(4558): 408-14), which posits that patients with the disease experience at least some cognitive abilities Decreased, which is caused by a deficiency of acetylcholine, thus resulting in a loss of cholinergic neurotransmitters

Method used

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  • Geranium oil and constituents thereof for treatment of neurodegenerative diseases
  • Geranium oil and constituents thereof for treatment of neurodegenerative diseases
  • Geranium oil and constituents thereof for treatment of neurodegenerative diseases

Examples

Experimental program
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Effect test

preparation example Construction

[0029] Extracts of P. graveolens can be prepared by conventional methods. An exemplary extraction method will be described below. In general, the preparation method includes: (1) drying selected plant parts, grinding the dried plant parts into a fine powder; (2) mixing the plant powder with an extraction solvent; (3) centrifuging to remove plant residues , select the solution supernatant; (4) remove the solvent and water in the residual supernatant by rotary evaporation, and dry. One of ordinary skill in the art will recognize that the method can be appropriately varied, for example, from small, or laboratory, batch extraction to a commercial scale method. For extraction purposes, a drying process may also be unnecessary. Fresh plant material can be directly solvent extracted without a drying step. Dried plant parts offer shipping and storage advantages; however, plant extracts from air-dried plant extracts will be less active than freeze-dried extracts, possibly due to inc...

Embodiment 1

[0064] Example 1: P. graveolens components that inhibit acetylcholinesterase activity.

[0065] In this example, human erythrocyte acetylcholinesterase (AChE) was incubated with different concentrations of geranium essential oil or each of its components.

[0066] Preparation and GC-MS analysis of essential oils.

[0067] P. graveolens was grown under cultivation conditions at the Newe Ya'ar Agricultural Experiment Station. Seeds were taken from a frozen seed bank and sown at the Newe Ya'ar Agricultural Experiment Station. Plants were grown on local clayey soils under drip irrigation as described in Dudai et al., (2003), Flavor and Fragrance Journal, 18, 334–337. Plant samples of at least 5 kg were steam distilled in a 130 L direct steam pilot plant unit for 1 hour. Essential oils were distilled with petroleum ether and injected into GC-MS, MSD (Agilent Technologies, Palo Alto, California, USA) with an autosampler Combi Pal (CTC Analytics, Zwingen, Switzerland), equipped wi...

Embodiment 2

[0070] Example 2: Differences in AChE activity between enantiomers of citronellol

[0071] Geranium essential oil contains two enantiomers of citronellol, namely [(R)(+):(S)(-)], in a ratio of about 80:20. Therefore, the inventors have tested the effect of both enantiomers on enzyme activity. As illustrated, only the enantiomer (S)(-)citronellol inhibits the enzymatic activity of acetylcholinesterase, while (R)(+)citronellol does not. image 3 It was shown that the difference between the different enantiomers of citronellol for AChE activity is significant. The different enantiomers of citronellol were incubated with human erythrocyte acetylcholinesterase (25mU / mL). A commercially available kit (Arbor assays Acetylcholinesterase Fluorescent Activity Detection Kit) was used to determine the activity of acetylcholinesterase.

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Abstract

The invention relates to the use of effective amount of Pelargonium graveolens essential oil or extract or constituents thereof selected from a group consisting of: (S)(-)citroneIlol, linalool, menthone and isomenthone or any combination thereof, in the preparation of a medicament for treating a mammal suffering from or susceptible to a neurodegenerative condition which can be improved or prevented by inhibition of acetylcholinesterase (ACliE).

Description

technical field [0001] The invention relates to a geranium essential oil preparation for treating neurodegenerative diseases, in particular to a geranium essential oil preparation capable of improving or preventing neurodegenerative diseases by inhibiting acetylcholinesterase (AChE). Background technique [0002] Essential oils are folk medicines, and in recent years their use has globally expanded to include the treatment of many types of inflammatory diseases, such as allergies, rheumatism, arthritis and bronchitis. These active effects are mainly known through clinical experience, but also have a small amount of experimental explanation. [0003] Geranium essential oil is one of the most important natural ingredients in the perfume industry. It is used to create rose-colored products, especially in soaps. The main origins are Reunion and Madagascar (Bourbon type), Morocco and Egypt (North African type) and China. [0004] Geranium essential oil is obtained by steam dis...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P25/16A61P25/28A61K31/045A61K31/122
CPCA23L1/3006A61K31/045A61K31/122A61K36/185A23L1/222A61K2300/00A23L27/12A23L33/105A23L33/115A61P25/16A61P25/28A23V2002/00
Inventor 亚拿·尔曼伍兹·约韦
Owner 以色列国家农业和农村发展部农业科研组织(ARO)(沃尔卡尼中心)
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