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Compound berberine sulfate injection for veterinary use and preparation method thereof

A technology of berberine sulfate and injection, which is applied in the field of veterinary compound berberine sulfate injection and its preparation, can solve the problems of no research reports and no products on the market, and achieve controllable process conditions, small dosage and frequent medication little effect

Inactive Publication Date: 2015-01-21
江西核工业瑞丰生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The data search also shows that there is no research report on this preparation, and no product is on the market. Therefore, the research invention of this preparation has the basic attributes of an invention patent

Method used

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  • Compound berberine sulfate injection for veterinary use and preparation method thereof
  • Compound berberine sulfate injection for veterinary use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prescription: berberine sulfate 5g, enrofloxacin 25g, polyethylene glycol (PEG400) 10g, sulfuric acid 5ml (approximately), sodium bisulfite 2g, water to 1000ml.

[0015] Process steps: Take an appropriate amount of water, heat it to 70-90°C, add an appropriate amount of sulfuric acid, mix well, add the prescribed amount of enrofloxacin and berberine sulfate in sequence to dissolve, and then add sulfurous acid pre-dissolved in water Sodium hydrogen, then add polyethylene glycol (PEG400) pre-dissolved in water, heat at 50-80°C for 1-2 hours to bond, adjust the pH value of the remaining sulfuric acid to 2.5-5.5, add water to the full amount; Zhongjian Berberis sulfate The relative content of alkali and enrofloxacin should meet the specified requirements, otherwise adjust with berberine sulfate, enrofloxacin or water; filter, potting; sterilize at 100°C for 30 minutes.

Embodiment 2

[0017] Prescription: berberine sulfate 5g, enrofloxacin 25g, xanthan gum 10g, gelatin 10g, sulfuric acid 3ml, acetic acid 3ml (approximately), sodium bisulfite 2g, L-cysteine ​​hydrochloride 1g, water to 1000ml.

[0018] Process steps: Take an appropriate amount of water, heat it to 70-90°C, add the prescribed amount of sulfuric acid, mix well, add the prescribed amount of enrofloxacin and berberine sulfate in turn to dissolve, and then add the pre-dissolved sub Sodium bisulfate and L-cysteine ​​hydrochloride, then add xanthan gum and gelatin pre-dissolved in water, keep warm at 50-80°C for 1-2 hours to bond, adjust the pH value to 2.5-5.5 with acetic acid, add water to Full amount; the relative content of berberine sulfate and enrofloxacin in the national inspection should meet the specified requirements, otherwise adjust with berberine sulfate, enrofloxacin or water; filter, potting; sterilize for 30 minutes at 100°C have to.

Embodiment 3

[0020] Prescription: berberine sulfate 10g, enrofloxacin 50g, polyvinyl alcohol (molecular weight: 110,000) 25g, hydrochloric acid 15ml (approximately), anhydrous sodium sulfite 2g, water to 1000ml.

[0021] Process steps: Take an appropriate amount of water, heat it to 70-90°C, add an appropriate amount of hydrochloric acid, and mix well, then add the prescribed amount of enrofloxacin and berberine sulfate to dissolve, and then add the pre-dissolved water Water sodium sulfite, then add polyvinyl alcohol pre-dissolved in water, keep warm at 50-80°C for 1-2 hours, adjust the pH value of the remaining hydrochloric acid to 2.5-5.5, add water to the full amount; Zhongjian berberine sulfate and enrofloxacin The relative content should meet the specified requirements, otherwise adjust with berberine sulfate, enrofloxacin or water; filter, potting; sterilize at 100°C for 30 minutes.

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Abstract

The invention discloses a prescription of a compound berberine sulfate injection for veterinary use and a preparation process thereof, belonging to veterinary drug technologies. The prescription consists of a main drug, an effect extending agent, a cosolvent, an antioxidant and water, and a high-concentration injection can be prepared. The injection is advanced in process, high in stability, long-acting, broad in spectrum, high-efficiency, small in irritation to the injection part and convenient to use, and the curative effect of the injection is obviously superior to that of single preparations of a berberine sulfate injection and an enrofloxacin injection. The injection comprises the following raw materials: 0.5-5.0 percent of berberine sulfate, 2.5-20.0 percent of enrofloxacin, 1-10 percent of effect extending agent, 1-10 percent of cosolvent, and 0.1-0.5 percent of antioxidant, wherein the effect extending agent refers to one or a mixture of several in polyethylene glycol, polyvinyl alcohol, povidone, hydroxyethyl cellulose, hydroxy propyl cellulose, carboxymethyl cellulose, hyaluronic acid, xanthan gum, gelatin, chitosan and alginate, the cosolvent refers to one or a mixture of several in sulfuric acid, hydrochloric acid, lactic acid, citric acid and acetic acid, and the antioxidant refers to one or a mixture of several in sodium hydrogen sulfite, anhydrous sodium sulfite, sodium formaldehyde sulfoxylate, sodium pyrosulfite, thiourea, L-cysteamine hydrochloride, vitamin C and ethidene diamine.

Description

technical field [0001] The invention relates to a compound berberine sulfate injection for animals and a preparation method thereof. Background technique [0002] Berberine sulfate is a purified and refined antibacterial drug from traditional Chinese medicine. It is a yellow needle-like crystal, odorless, and has a very bitter taste. It has inhibitory effects on a variety of Gram-positive bacteria and Gram-negative bacteria. bacillus, Salmonella, typhoid bacillus, Pasteurella, Escherichia coli, Staphylococcus aureus, Freund's, Shigella dysenteriae, etc. all have antibacterial effects, and can enhance the phagocytosis of white blood cells, and have different degrees of protection against Mycobacterium tuberculosis and Yersinia pestis It also has antipyretic and antiarrhythmic effects. Berberine sulfate is mainly used for intestinal infections caused by bacteria and viruses, various acute and chronic gastroenteritis, epidemic diarrhea, chronic diarrhea, malignant diarrhea, cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61P11/00A61P1/12A61P31/04A61K31/4375
CPCA61K31/496A61K9/08A61K31/4375
Inventor 陈金兴李龙瑞王新斌孔晟郭春玉柳涛陈玉林
Owner 江西核工业瑞丰生物药业有限公司
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