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Preparation method for compound radix isatidis granules

A technology of compound banlan and granules, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of effective ingredient wrapping precipitation yield, large amount of ethanol, difficult problems, etc., to achieve process optimization, Effect of reducing ethanol concentration and cost reduction

Active Publication Date: 2015-01-21
ZHONGSHAN NIKEMEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are some deficiencies in this production method, such as the liquid must be placed until the temperature drops to room temperature before adding ethanol, but due to the gelatinization of starch, the liquid becomes jelly, and it is difficult to make ethanol enter the jelly to dissolve effectively The active ingredient is wrapped by the precipitated gelatinized starch at the same time, and there is a disadvantage that the amount of ethanol is large, and the active ingredient is easy to be wrapped and precipitated, resulting in a decrease in yield.

Method used

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  • Preparation method for compound radix isatidis granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Decoct the Radix isatidis raw material with water for two times, the first time for 2 hours, the second time for 1 hour, combine the decoction, and filter;

[0021] 2) The filtrate is concentrated to a relative density of 1.10, and the temperature is 45° C., adding a compound enzyme composed of pectinase, cellulase, and pectin lyase for enzymolysis, and the weight of pectinase, cellulase, and pectin lyase is The ratio is 5:3:2, and the compound enzyme addition is 0.5% of the concentrated filtrate weight;

[0022] 3) Continue to concentrate until the relative density is 1.20, the temperature is 45°C, filter, cool, add 95% ethanol to make the alcohol content 30%, static precipitation, and extract the supernatant;

[0023] 4) Recover ethanol and concentrate it to a relative density of 1.20 at a temperature of 70°C;

[0024] 5) Add conventional amounts of sucrose and dextrin to make granules and dry.

Embodiment 2

[0026] 1) Decoct the Radix isatidis raw material with water for two times, the first time for 2 hours, the second time for 1 hour, combine the decoction, and filter;

[0027] 2) The filtrate is concentrated to a relative density of 1.10, and the temperature is 45° C., adding a compound enzyme composed of pectinase, cellulase, and pectin lyase for enzymolysis, and the weight of pectinase, cellulase, and pectin lyase is The ratio is 5:3:2, and the compound enzyme addition is 1.0% of the concentrated filtrate weight;

[0028] 3) Continue to concentrate until the relative density is 1.20, the temperature is 45°C, filter, cool, add 95% ethanol to make the alcohol content 30%, static precipitation, and extract the supernatant;

[0029] 4) Recover ethanol and concentrate it to a relative density of 1.20 at a temperature of 70°C;

[0030] 5) Add conventional amounts of sucrose and dextrin to make granules and dry.

Embodiment 3

[0032] 1) Decoct the Radix isatidis raw material with water for two times, the first time for 2 hours, the second time for 1 hour, combine the decoction, and filter;

[0033] 2) The filtrate is concentrated to a relative density of 1.10, and the temperature is 45° C., adding a compound enzyme composed of pectinase, cellulase, and pectin lyase for enzymolysis, and the weight of pectinase, cellulase, and pectin lyase is The ratio is 5:3:2, and the compound enzyme addition is 0.8% of the concentrated filtrate weight;

[0034] 3) Continue to concentrate until the relative density is 1.20, the temperature is 45°C, filter, cool, add 95% ethanol to make the alcohol content 30%, static precipitation, and extract the supernatant;

[0035] 4) Recover ethanol and concentrate it to a relative density of 1.20 at a temperature of 70°C;

[0036] 5) Add conventional amounts of sucrose and dextrin to make granules and dry.

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PUM

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Abstract

The invention discloses a preparation method for compound radix isatidis granules. The preparation method comprises the steps as follows: firstly, adding water in radix isatidis raw and decocting twice with the first time and the second time being 2 hours and one hour respectively, merging the decocted soup and filtering the soup; secondly, concentrating the filtered soup with the relative density being 1.10, at 45 DEG C, adding complex enzyme consisting of pectinase, cellulase and pectate lyase for enzymolysis, wherein the weight ratio of the pectinase to the cellulase to the pectate lyase is 5 to 3 to 2, and the addition amount of the complex enzyme is 0.5-1.0% of the weight of the concentrated filtered soup; thirdly, concentrating continuously till the relative density being 1.20, at 45 DEG C, filtering, cooling, adding 95% ethyl alcohol so as to enable the alcohol content to be 30%, leaving to stand for sedimentation, and extracting supernatant liquid; fourthly, recycling ethyl alcohol, concentrating the liquid with the relative density being 1.20 at the temperature of 70 DEG C; fifthly, adding regular amount of cane sugar and dextrin, preparing granules, and drying the granules. According to the preparation method provided by the invention, through adopting the enzymolysis technology additionally, the ethanol concentration during ethanol sedimentation is reduced, and the cost is lowered.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of compound isatidis granules. Background technique [0002] Banlangen (commonly used aliases: indigo root, blue indigo root, Daqing root) is a traditional Chinese medicine. Produced all over China. Isatis root is divided into northern isatis root and southern isatis root. The source of northern isatis root is the roots of cruciferous plants Isatis tinctoria L. and grass Daqing (I. indigotica Fort.); The rhizome and roots of cusia (Nees) Brem.) have the effects of clearing away heat and detoxification, preventing colds and relieving sore throat. Indications: Warm poison spots, high fever and headache, big head plague, crimson purple tongue, rotten throat Dansha, erysipelas, mumps, sore throat, sores, carbuncles, chickenpox, measles, hepatitis, influenza, meningitis, B Cerebral, pneumonia, stupor, vomiting, pharynx swelling, burning eyes, sores; it can pr...

Claims

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Application Information

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IPC IPC(8): A61K36/195A61K36/315A61K9/16A61P11/00A61P11/04A61P31/16
CPCA61K9/1652A61K36/195A61K36/315A61K2236/19A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 黄琴
Owner ZHONGSHAN NIKEMEI PHARMA
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