Peripheral blood circulation tumor cell detection chip and system thereof

Abstract

The invention relates to a peripheral blood circulation tumor cell detection chip and a system thereof. The detection chip comprises a substrate, and the substrate is provided with an interdigital capacitance circuit and a spiral inductor metal circuit connected with the interdigital capacitor circuit; the interdigital capacitor circuit tightly laminated with a single layer graphene film; the graphene film is laminated with a micro-fluidic control channel; the micro-fluidic control channel and the single layer graphene film form an integrated graphene micro-fluidic pipe screening microchip for screening tumor cells; the single layer graphene film, the interdigital capacitor circuit and the spiral inductor circuit form a whole RCL resonance network; the spiral inductor circuit is also used as a cross coupling antenna. The detection system comprises a detection signal reading and analysis device, and the peripheral blood circulation tumor cell detection chip. The chip and the system can realize the fast, sensitive, accurate and cheap detection of tumor cells.

Description

technical field [0001] The invention relates to the technical field of tumor detection, in particular to a peripheral blood circulating tumor cell detection chip and system based on radio frequency wireless detection technology. Background technique [0002] Circulating tumor cells refer to tumor cells that fall off from tumor tissues and enter peripheral blood. A large number of research data have confirmed that the rapid detection of circulating tumor cells in blood has important application value for tumor detection, individualized treatment, curative effect evaluation and prognosis monitoring. Compared with traditional imaging and pathological tumor diagnosis methods, the detection of circulating tumor cells has unique advantages. First of all, the circulating tumor cell detection method can simultaneously screen most multiple solid tumors such as lung cancer, gastric cancer, and liver cancer at one time, and has a larger detection range. At the same time, only blood te...

AI Technical Summary

Problems solved by technology

[0003] At present, the existing detection methods based on circulating tumor cells generally use enzyme-linked immunosorbent assay or polymerase chain reaction, which often require harsh experimental conditions, relatively expensive experimental equipment and reagents.

However, the detection method using fluorescent spectrum labeling often requires a relatively complicated and cumbersome detection process, which takes a long time, which is not conducive to the rapid and efficient tumor analysis and detection requirements in clinical applications.

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