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Rhodiola rosea extract and application thereof

A Rhodiola rosea, extract technology, applied in application, food science, drug combination and other directions, can solve the problems of elevated liver enzymes, aggravation of the disease, toxic and side effects, etc. Avoid the effects of toxic side effects

Inactive Publication Date: 2015-01-28
GUANGZHOU SHENNONG BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, α-glucosidase inhibitors have the disadvantages of certain toxic side effects, which may cause allergic reactions, chronic intestinal disturbances of digestion and absorption disorders, conditions that may worsen due to flatulence, hernia, intestinal obstruction, and intestinal ulcers etc. At the same time, it is worth noting that when acarbose tablets are used in large doses, asymptomatic liver enzymes will increase. For patients with normal liver function, the liver enzymes will return to normal after stopping the drug. It will aggravate the condition and cause damage; therefore, it is necessary to develop a new class of safer oral hypoglycemic drugs

Method used

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  • Rhodiola rosea extract and application thereof
  • Rhodiola rosea extract and application thereof
  • Rhodiola rosea extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Precisely weigh 5 grams of crushed Rhodiola rosea medicinal material, ultrasonically extract with 70% ethanol (according to medicinal material (w):solvent (v)=1:8) for 30 minutes, filter, and combine the filtrate twice in the same operation. Evaporate to dryness at 65° C. on a rotary evaporator to obtain 1.2807 g of No. 1 Rhodiola rosea extract.

Embodiment 2

[0034] Precisely weigh 5 grams of crushed Rhodiola rosea medicinal material, ultrasonically extract with 95% ethanol (according to medicinal material (w): solvent (v) = 1:8) for 30 min, filter, and combine the filtrate twice in the same operation. Evaporate to dryness at 65° C. on a rotary evaporator to obtain 0.8411 g of No. 2 Rhodiola rosea extract.

Embodiment 3

[0036] Precisely weigh 5 grams of crushed Rhodiola rosea medicinal material, sonicate with 95% ethanol (according to medicinal material (w): solvent (v) = 1:8) for 30 minutes, and filter. The filter residue was boiled with water (1:8 water) for 30 minutes, filtered and squeezed dry with gauze, and the filtrates were combined twice in the same operation. Evaporate to dryness at 65° C. on a rotary evaporator to obtain 1.2858 g of No. 3 Rhodiola rosea extract.

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Abstract

The invention relates to a rhodiola rosea extract. The rhodiola rosea extract comprises 5-70% of rhodiola rosea polyphenol by mass percent. A preparation method comprises the following steps: drying and smashing the medicinal material of rhodiola rosea; mixing with water or an organic solvent in a mass-volume ratio of 1: (3-50), and extracting one or more for treatment by utilizing decoction, quenching or ultrasounds; filtering medicine residues, drying on a rotary evaporator at 65 DEG C to obtain the rhodiola rosea extract. The rhodiola rosea extract has the activity of an alpha-glucosidase inhibitor, the postprandial blood sugar of a patient with diabetes can be reduced, and the rhodiola rosea extract can be applied to medicine, food and health care products with a hypoglycemic function and medicine, food and health care products for treating and preventing diabetes. The rhodiola rosea extract has the advantages that the postprandial blood sugar can be quickly and effectively reduced; compared with the commonly-used alpha-glucosidase inhibitor, the toxic and side effect is lower, and the problem that combination use of drugs easily causes hypoglycemia is effectively solved.

Description

technical field [0001] The invention relates to natural plant extraction, and specifically designs the extraction and application of an α-glucosidase inhibitor derived from the traditional herbal medicine Rhodiola rosea. Background technique [0002] Diabetes is a metabolic disease caused by endocrine disorders, which is extremely harmful to human health. Its metabolic disorders can lead to chronic complications in various tissues such as kidneys, nerves, eyes, and cardiovascular and cerebrovascular tissues. In severe cases, ketoacidosis, coma, etc., and it is easy to cause cross-infection. According to a study published in the authoritative medical journal "The Lancet" in June 2011, there are currently about 347 million diabetic patients in the world. The situation in my country is not optimistic either. At present, the number of diabetic patients in my country has reached 92.4 million, becoming the largest country with diabetes. Among them, the prevalence rate of adults o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P3/10A23L1/29A23L33/00
CPCA61K36/41A23V2002/00A61K2236/33A61K2236/331A61K2236/51A61K2236/53A61K2236/55
Inventor 李莹雪黄静贤王锐银李乾坤丁韵芸
Owner GUANGZHOU SHENNONG BIOLOGICAL TECH
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