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Osmanthus phenylethanoid glycoside extract, and preparation method and application thereof

A technology of phenylethanol glycosides and total phenylethanol glycosides from osmanthus fragrans, which is applied in the field of phenylethanol glycoside extracts, can solve the problems of not paying attention to the stability of phenylethanol glycoside compounds, the extraction yield and the influence of the purity of the extract, and achieve good quality and composition Clear, wide-source effects

Active Publication Date: 2014-05-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the traditional extraction of osmanthus polyphenols, no attention has been paid to the stability of phenylethanol glycosides, so the extraction yield and the purity of the extract are affected. Therefore, measures need to be taken during the extraction process to prevent the oxidation and decomposition of phenylethanol glycosides

Method used

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  • Osmanthus phenylethanoid glycoside extract, and preparation method and application thereof
  • Osmanthus phenylethanoid glycoside extract, and preparation method and application thereof
  • Osmanthus phenylethanoid glycoside extract, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Crush 1 kg of dried Jingui flowers (moisture content ≤ 10%, crushed to pass through a 20-mesh sieve), add 15L of 80% (volume %) ethanol aqueous solution, and then add 0.1% sodium erythorbate aqueous solution (that is, each 1 liter of sodium erythorbate aqueous solution contains 1g of sodium erythorbate) 2L, use 1mol / L formic acid aqueous solution to adjust the pH of the extraction solution to about 5; extract at a temperature of 50°C to 80°C for 2 hours, cool to room temperature, and filter to obtain the extract Liquid; Concentrate the extract directly under reduced pressure (at 0.010-0.100MPa, temperature 50-60°C), recover ethanol to obtain a concentrated solution (about 4L), then dilute with water until the pH of the diluted solution is about 5; The liquid is absorbed by the adsorption resin (the adsorption resin is HPD300, the dosage is 1L), and it is eluted with 2L of 30% (volume %) ethanol aqueous solution; ), after spray drying (inlet air temperature is 180-200°C,...

Embodiment 2

[0087] Crush 1 kg of dried osmanthus osmanthus (water content ≤ 10%, crushed to pass through a 20-mesh sieve), add 10 L of 90% (volume %) ethanol aqueous solution, and then add 0.2% ascorbic acid aqueous solution (that is, each liter of ascorbic acid aqueous solution containing 2g ascorbic acid) 2L, use 0.5mol / L acetic acid aqueous solution to adjust the pH of the extraction solution to about 4; extract at a temperature of 50°C to 80°C for 2 hours, cool to room temperature, and filter to obtain the extract; directly extract the extract Concentrate under reduced pressure (at 0.010-0.100MPa, temperature 50-60°C), recover ethanol, obtain a concentrated solution (about 1.5L), and then dilute with water until the pH of the diluted solution is about 4; absorb the diluted solution with an adsorption resin (The adsorption resin is HPD300, the dosage is 1L), and it is eluted with 2L of 30% (volume %) ethanol aqueous solution; After microwave drying (process parameters: microwave power ...

Embodiment 3

[0090]Crush 1 kg of dried Osmanthus osmanthus (water content ≤ 10%, crushed to pass through a 20-mesh sieve), add it to 10 L of 90% (volume %) ethanol solution, and then add 0.1% bamboo leaf antioxidant aqueous solution (that is, the Each liter of bamboo leaf antioxidant aqueous solution contains 1g of bamboo leaf antioxidant) 2L, using 1mol / L acetic acid aqueous solution to adjust the pH of the extraction solution to about 5; the extraction solution is obtained; the extraction solution is carried out at a temperature of 50°C to 80°C Leach for 2 hours, cool to room temperature, and filter to obtain the extract; directly concentrate the extract under reduced pressure (at 0.010-0.100MPa, temperature 50-60°C), recover ethanol, and obtain a concentrate (about 2.5L), Then dilute with water until the pH of the diluted liquid is about 4; absorb the diluted liquid with an adsorption resin (the adsorption resin is HPD300, the dosage is 1 L), and elute with 2 L of 30% (volume %) ethanol ...

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Abstract

The invention discloses an osmanthus phenylethanoid glycoside extract. The total phenylethanoid glycoside content in the osmanthus phenylethanoid glycoside extract is 30-90 wt%; and the total phenylethanoid glycosides comprise verbascoside and isoverbascoside. The verbascoside content in the osmanthus phenylethanoid glycoside extract is 25-80 wt%, and the weight ratio of the verbascoside to the isoverbascoside in the total phenylethanoid glycosides is 48:1-300:1. The invention also discloses a preparation method of the osmanthus phenylethanoid glycoside extract and application of the osmanthus phenylethanoid glycoside extract in preparing foods, drugs or health products for preventing and treating diabetes.

Description

technical field [0001] The invention relates to the field of intensive processing and comprehensive utilization of agricultural and sideline products. More specifically, it relates to a phenylethanol glycoside extract extracted from osmanthus fragrans and its preparation method and application. Background technique [0002] Osmanthus fragrans, also known as sweet-scented osmanthus and rock osmanthus, is one of the top ten traditional Chinese flowers. It is widely planted in the Huaihe River Basin and the areas to the south. At present, my country has formed Hangzhou in Zhejiang, Lu'an in Anhui, Xianning in Hubei, Taoyuan in Hunan, Suzhou in Jiangsu, and Guilin in Guangxi. Several major osmanthus commodity production bases such as Wuhan, Hubei and Chengdu, Sichuan. There are many varieties of osmanthus, about 152 varieties, which can be divided into four strains, namely Sijigui, Dangui, Yingui and Jingui. In addition to being ornamental and beautifying, osmanthus also has hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61K8/97A23L1/29A61P3/10A61K133/00A23L33/00
Inventor 陆柏益熊丽娜毛淑琴周菲蒋易蓉孙启鸿杨佳佳胡银洲谌灿曦
Owner ZHEJIANG UNIV
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