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Application of water-soluble silicon quantum dots as drug carriers

A technology of water-soluble silicon and silicon quantum dots, which is applied in the field of medicine to achieve the effects of low cytotoxicity, good water solubility and high purity

Inactive Publication Date: 2015-01-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Purpose of the invention: In order to overcome the deficiencies of the above-mentioned prior art, the present invention uses silicon quantum dots as drug carriers for the first time. It has the disadvantages of crossing the blood-brain barrier and being unable to enter the urine through the glomerular vessel wall and then excreted from the body. At the same time, the silicon quantum dot-anticancer drug complex has a certain slow-release effect

Method used

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  • Application of water-soluble silicon quantum dots as drug carriers

Examples

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Embodiment 1

[0033] The preparation of thiolated doxorubicin (HS-DOX) comprises the following steps:

[0034] (1) Dissolving doxorubicin in a solution (pH=8.0) of dimethyl sulfoxide (DMSO) and phosphate buffer (PBS), to which Traut's reagent is added in an amount twice the amount of doxorubicin;

[0035] (2) React at room temperature for 1 hour to obtain thiolated doxorubicin.

Embodiment 2

[0037] The preparation of water-soluble silicon quantum dots with amino groups on the surface comprises the following steps:

[0038] (1) feed nitrogen into the sodium citrate aqueous solution, remove the oxygen in the solution;

[0039] (2) Add 3-(2-aminoethylamino)propyltrimethoxysilane (DAMO) while stirring, and stir for 10min in a closed state to form a silicon quantum dot precursor solution; DAMO and sodium citrate aqueous solution The mass ratio is 5:1; the mass fraction of the silane reagent is 20%;

[0040] (3) React in a microwave reactor at 160°C for 15 minutes to form a DAMO silicon quantum dot solution;

[0041] (4) Dialyzing the silicon quantum dot solution with a dialysis bag with a molecular weight of 1000 to obtain a pure DAMO silicon quantum dot solution.

Embodiment 3

[0043] The preparation of maleimide silicon quantum dots comprises the following steps:

[0044] The DAMO silicon quantum dot that embodiment 2 makes and NHS-EG 10 -MAL was reacted in a phosphate buffer solution with pH=7.4 for 4 hours according to a substance ratio of 1:3 to obtain maleimidized silicon quantum dots.

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Abstract

The invention provides application of water-soluble silicon quantum dots as drug carriers. A preparation method of a silicon quantum dot-drug molecule composition comprises the following concrete steps: preparing aminated silicon quantum dots, performing maleimide treatment on the surfaces of the aminated silicon quantum dots, and preparing the silicon quantum dot-drug molecule composition. According to the method, the silicon quantum dots are connected with drug molecules through short-chain polyethylene glycol molecules, and the prepared silicon quantum dot-drug molecule composition has the advantages of high purity, good water solubility, protein adsorption resistance, no additional fluorescent mark, capability of achieving passive targeting in the body, capability of entering urine through the blood-brain barrier and the glomerular vascular wall to be discharged from the body, a certain drug slow-release effect and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of water-soluble silicon quantum dots as drug carriers. Background technique [0002] Silicon is the second most abundant element in the earth's crust and an essential element in the human body. Because of the advantages of good biocompatibility, special optical properties, low biotoxicity and easy surface modification, silicon-based nanomaterials have attracted widespread attention, including silicon nanowires, silicon nanotubes, silicon quantum dots (or silicon nanoparticles), etc. [0003] At present, related groups have reported the use of doxorubicin (DOX) molecules and physical adsorption on the porous surface of silicon nanowires to use silicon nanowires as carriers of the anticancer drug doxorubicin (Su, Y.Y. and He, Y. et al ., Biomaterials, 2014, 35, 5188-5195; Lee, S.T. and He, Y.Et.al, Angew.Chem.Int.Ed., 2013, 52, 1457-1461). However, ...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61P35/00A61K31/704
Inventor 吴富根张晓东陈晓凯杨婧婧陈战
Owner SOUTHEAST UNIV
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