A kind of benzbromarone crystal form b and preparation method thereof

A technology of benzbromarone and crystal form, applied in the field of chemical pharmacy, can solve the problems of poor industrial application of crystallization and purification method, inestimable market potential, poor stability of drug form, etc., and achieves low cost, mild conditions and good stability. Effect
CN104311516BActive Publication Date: 2017-01-11NORTHEAST PHARMA GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTHEAST PHARMA GRP
Publication Date
2017-01-11

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Abstract

A benzbromarone crystal form B applied in the field of chemical pharmacy and a preparation method thereof, the benzbromarone crystal form B, in the X-ray powder diffraction pattern represented by the 2θ angle, the error range of the 2θ angle ± 0.2; the described benzbromarone crystal form B has a basic X-ray powder diffraction spectrum in the X-ray powder diffraction spectrum represented by the 2θ angle; the described benzbromarone crystal form B is in In the differential scanning calorimetry chart, there is a maximum endothermic peak when the heating rate is 10°C per minute, the peak start point: 150.54°C, the peak value: 151.62°C, the peak end point: 153.82°C, the melting point of benzbromarone crystal form B: 151.66°C; at 25°C, take 1.0g of the benzbromarone crystal form B, add 10ml of chloroform, the solid is slightly insoluble, and the solution is not clear; and take 1.25g of the benzbromarone crystal form B, add N,N ‑Dimethylformamide 25ml, all solids were dissolved, and the solution was clear. The invention has good crystal form stability, simple preparation method, low cost, simple post-treatment, high purity of the prepared product and less related substances.
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Description

technical field

[0001] The invention relates to a benzbromarone crystal form B in the field of chemical pharmacy and a preparation method thereof. Background technique

[0002] Benzbromarone, also known as benzobromone, tongfenglixian, tongfengning, etc. This product is a derivative of benzofuran, which can inhibit the reabsorption of uric acid by renal tubules and thus reduce the concentration of uric acid in blood. It is easily absorbed orally, and its metabolites are effective. The uric acid in the blood 24 hours after taking the medicine is 66.5% of that before taking the medicine. For the treatment of gout.

[0003] Benzbromarone was launched in Germany in 1971, licensed under the trade name of Urinorm in August 1978, and started selling tablets in April 1979. Since Benzbromarone entered my country in 2000, it has occupied the No. 1 position of anti-gout drugs in hospitals. Moreover, the market share of Benzbromarone is still on the rise, and its market potential is ...

Claims

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