Method and application for rapidly detecting caulis spatholobi medicine material by using near infrared spectroscopy method

A near-infrared spectroscopy and near-infrared spectroscopy technology, which is applied in the field of rapid detection of Caulis Spatholobus medicinal materials, can solve the problems that cannot meet the needs of the modernization of traditional Chinese medicine preparations, cannot reflect the complexity of traditional Chinese medicine ingredients, and difficult production practices, etc., to improve production Efficiency and economic benefits, shortened detection time, and high accuracy

Inactive Publication Date: 2015-01-28
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the traditional quality detection method of Mildew Spatholobus is time-consuming and laborious, and it is difficult to be widely used in production practice. It cannot meet the needs of the modern development of traditional Chinese medicine preparations, and often uses a single index component to control the quality of medicinal materials, which cannot reflect the complexity of traditional Chinese medicine ingredients. Therefore, there is an urgent need for a rapid and comprehensive method for detecting the medicinal materials of Spatholobus Spatholobus to meet the requirements of screening and quality control of large quantities of medicinal materials of Spatholobus Spatholobus

Method used

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  • Method and application for rapidly detecting caulis spatholobi medicine material by using near infrared spectroscopy method
  • Method and application for rapidly detecting caulis spatholobi medicine material by using near infrared spectroscopy method
  • Method and application for rapidly detecting caulis spatholobi medicine material by using near infrared spectroscopy method

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Experimental program
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Effect test

Embodiment 1

[0045] A. Determination of moisture content includes the following steps:

[0046] (1) After selecting 112 parts of the medicinal materials of Mildew Spatholobus from different origins with known moisture content and pulverizing them, passing through an 80-mesh sieve to obtain the medicinal powder of Mildew Spatholobus with relatively uniform particle size, which is set aside; Drying method is used to measure the moisture content of the said Caulis Spatholobus medicinal material, and the concrete steps are as follows:

[0047] Take 1 g of the medicinal material powder of Mildew Spathifolia and place it in a flat bottle (X 0 ), and then precisely weighed (X 1 ), open the bottle cap, the flat bottle (X 1 ) in an oven at 105°C for 5 hours, then take it out and place it in a desiccator to cool for 30 minutes, weigh it immediately, then place it in an oven at 105°C for 1 hour, and weigh it precisely (X 2 ), those whose weight difference is more than 5mg continue to be baked in t...

Embodiment 2

[0058] B. The determination of extract content includes the following steps:

[0059] (1) Select a total of 112 parts of Mildew Spatholobus medicinal materials originating from different origins with known extract content and pulverize them, pass through an 80-mesh sieve to obtain Mildew Spatholobus medicinal material powder with relatively uniform particle size, and set aside; wherein said Mildew Spatholobus medicinal material Determination of the content of the extract according to the hot dip method, the specific steps are as follows:

[0060] Get 1g of the powder of Mildew Spatholobus, accurately weighed (X 1 ), then placed in a 50ml Erlenmeyer flask, accurately added 25ml of ethanol, sealed, weighed, left to stand for 1h, then refluxed at 85°C for 1h, let cool, weighed, and made up the lost weight with ethanol , shake well, place in a 15ml centrifuge tube and centrifuge for 30min at a speed of 3800r / min, accurately measure 10ml of the supernatant, and place it in a flat ...

Embodiment 3

[0072] C, the mensuration of total flavonoid content comprises the following steps:

[0073] (1) Select a total of 112 parts of Mildew Spatholobus medicinal materials derived from different origins with known total flavonoid content and pulverize them, pass through an 80-mesh sieve to obtain Mildew Spatholobus medicinal material powder with a relatively uniform particle size, and set aside; Determination of the content of total flavonoids according to ultraviolet spectrophotometry, concrete steps are as follows:

[0074] a. The pretreatment method is as follows: take 0.3g of Spatholobus medicinal material powder (through 80 mesh sieve), accurately weigh, accurately add 25ml of 50% ethanol in mass concentration, ultrasonically extract for 1h, make up for weight loss with 50% ethanol, take an appropriate amount The solution was centrifuged in a 1.5ml centrifuge tube for 10min at a speed of 13000r / min, and the supernatant was taken to obtain the test solution;

[0075] b. Color ...

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Abstract

The invention belongs to the technical field of medicine detection, and particularly relates to a method and application for rapidly detecting a caulis spatholobi medicine material by using a near infrared spectroscopy method. The method comprises the following steps: (1) crushing and screening a caulis spatholobi medicine material with known content of moisture, extractum and total flavonoid, for later use; (2) acquiring the near infrared spectroscopy data of the caulis spatholobi medicine powder; (3) coupling spectral information of a characteristic wave band with the known moisture content of the caulis spatholobi medicine, and establishing a quantitative calibration model by using a partial least square; (4) performing near infrared spectrum scanning on an unknown caulis spatholobi medicine sample according to the step (2), and introducing the spectral information under the characteristic band into the established quantitative calibration model, thereby obtaining the moisture content value of the unknown caulis spatholobi medicine sample. By adopting the near infrared spectroscopy technique, rapid and comprehensive detection on the caulis spatholobi medicine is achieved, and the method has the advantages of simple operation, high accuracy and high precision.

Description

technical field [0001] The invention belongs to the technical field of medicinal material detection, and in particular relates to a method and an application for rapidly detecting the medicinal material of Spatholobus Spatholobus by using near-infrared spectroscopy. Background technique [0002] Spatholobus suberectus Dunn is the dried rhizome of the leguminous plant Spatholobus suberectus Dunn, and its effective chemical components mainly include flavonoids, coumarins, anthraquinones and triterpenes. The 2010 edition of "Chinese Pharmacopoeia" records that Spatholobus Spatholobus has the functions of invigorating blood and nourishing blood, regulating menstruation and relieving pain, and activating meridians and activating collaterals. . Since the chemical composition of Mildew Spatholobus is relatively complex, and the quality of Mildew Spatholobus can be affected by factors such as variety, source, place of origin, and growth period, if Mildew Spatholobus is used as a ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3563
Inventor 陈红英栾连军张跃飞刘志刚李琼娅陈佳乐金叶马舒冰马鹏岗
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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