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Mequindox injection and preparation method thereof

A technology for acemetaquine and injection, which is applied in the field of preparation of acemetaquine injection, can solve problems such as inability to guarantee quality and stability, and achieve the effects of easy storage and transportation, improved solubility, and improved stability

Active Publication Date: 2015-02-04
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of acemethaquine injection, solve the problem that the product quality and stability of the existing acemethaquine single preparation cannot be guaranteed

Method used

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  • Mequindox injection and preparation method thereof
  • Mequindox injection and preparation method thereof
  • Mequindox injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The acemetquine injection of the present embodiment, every 100L injection comprises the following components:

[0025]

[0026] The preparation method of the acetylmethaquine injection of the present embodiment may further comprise the steps:

[0027] 1) Take benzyl alcohol, 95% ethanol and propylene glycol of formula quantity and mix uniformly to obtain cosolvent;

[0028] 2) Add water for injection accounting for 10% of the volume of the formula balance to the co-solvent obtained in step 1), then add a formula amount of stabilizer and acemethaquine, stir and dissolve to obtain a mixture;

[0029] 3) Use ethanolamine to adjust the pH value of the mixture obtained in step 2) to 7.5, add water for injection to the full amount, filter, fill with nitrogen gas, and sterilize at 121°C and 0.15MPa for 20 minutes to obtain the acemetquine Injection.

Embodiment 2

[0031] The acemetquine injection of the present embodiment, every 100L injection comprises the following components:

[0032]

[0033] The preparation method of the acetylmethaquine injection of the present embodiment may further comprise the steps:

[0034] 1) Take benzyl alcohol, 95% ethanol and propylene glycol of formula quantity and mix uniformly to obtain cosolvent;

[0035] 2) Add water for injection accounting for 20% of the formula balance volume to the co-solvent obtained in step 1), then add a formula amount of stabilizer and acemetquine, stir and dissolve to obtain a mixture;

[0036] 3) Use ethanolamine to adjust the pH value of the mixture obtained in step 2) to 4.5, add water for injection to the full amount, filter, fill with nitrogen gas, and sterilize at 121°C and 0.15MPa for 20 minutes to obtain the acemetquine Injection.

Embodiment 3

[0038] The acemetquine injection of the present embodiment, every 100L injection comprises the following components:

[0039]

[0040] The preparation method of the acetylmethaquine injection of the present embodiment may further comprise the steps:

[0041] 1) Take benzyl alcohol, 95% ethanol and propylene glycol of formula quantity and mix uniformly to obtain cosolvent;

[0042] 2) Add water for injection accounting for 15% of the volume of the formula balance to the co-solvent obtained in step 1), then add a formula amount of stabilizer and acemethaquine, stir and dissolve to obtain a mixture;

[0043] 3) Use ethanolamine to adjust the pH value of the mixture obtained in step 2) to 6, add water for injection to the full amount, filter, fill with nitrogen gas, and sterilize at 121°C and 0.15MPa for 20 minutes to obtain the acemetquine Injection.

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Abstract

The invention discloses a mequindox injection and a preparation method thereof. Per 100L of the injection comprises following components: 2-8 kg of the mequindox, 40-90 L of a cosolvent, 50-150g of a stabilizing agent and the balanced water for injection. The mequindox injection is prepared by compounding the mequindox, the cosolvent and the stabilizing agent so that the mequindox can be quickly dissolved without heating. The mequindox injection is free of separation-out of effective components, turbidity and layering during a long-period storage process, has a long-period quality stability, has significantly curative effects on diseases, such as bacillary enteritis, dysentery and the like, is a single-formula injection, is free of other effective components except for the mequindox so that a drug-resistant problem caused by mis-preparation and mis-utilization of drugs and a problem that the quality of the compounded preparation is difficult to detect and control, is strong in stability, is good in curative effects, is low in cost, is easy to store and transport and is suitable for popularized utilization.

Description

technical field [0001] The invention belongs to the technical field of preparation of medicaments, and in particular relates to an acemethaquine injection, and also relates to a method for preparing the acemetaquine injection. Background technique [0002] Methoquine (C 11 h 10 N 2 o 3 ), also known as dysentery net, is a special antibacterial drug for veterinary medicine unique to our country. It belongs to synthetic quinoxaline drugs and has broad-spectrum antibacterial effect. The inhibitory effect on Gram-negative bacteria is stronger, and it is also effective on spirochetes. Its mechanism of action is to inhibit the DNA synthesis of bacteria to achieve antibacterial effect. [0003] The dosage forms of methaquine mainly include tablets and injections. Due to the limited use of tablets, the powdered product of methaquine has been cancelled, and the injection of methaquine has become its main form of preparation. Most of the methaquine injections currently on the ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/498A61K47/10A61P31/04A61P1/12
CPCY02A50/30
Inventor 郭玉凡王佳伟王颖杜丹丹周衡
Owner ZHENGZHOU BARY ANIMAL PHARMA
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