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Galangin extraction method

A technology of galangin and extraction method, which is applied in the direction of organic chemistry, can solve the problems of waste of medicinal materials, the purity of galangin can not meet the requirements of medical raw materials, etc., and achieve the effect of cost saving and convenient operation

Inactive Publication Date: 2015-02-11
SHANGHAI U SEA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This has caused the purity of galangin to fail to meet the requirements of medical raw materials, and is accompanied by the waste of medicinal materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] ①Galangal (Alpinia officinarum Hance) dried medicinal material was crushed into a coarse powder with a powder machine, and extracted twice with 75% ethanol by volume, the ratio of solid to liquid was 5 times, and each time was 1 hour. The ethanol extract is concentrated, and the ethanol concentrate is recovered; the concentrate is added with an appropriate amount of water, and extracted twice with an equal volume of ethyl acetate; the ethyl acetate layer is concentrated, and the ethyl acetate concentrate is recovered to obtain a crude galangin extract;

[0030] ② Add an appropriate amount of normal-phase silica gel to the obtained total crude extract, mix the sample and drain it, and place it on the top of a silica gel column for column chromatography separation, and use petroleum ether-ethyl acetate gradient elution;

[0031] ③ The eluted fractions were detected by thin layer chromatography (TLC). TLC method: developer: toluene: ethyl acetate: formic acid = 6.5: 3: 0.5...

Embodiment 2

[0038] ①Galangal (Alpinia officinarum Hance) dried medicinal material was crushed into a coarse powder with a powder machine, and extracted twice with 75% ethanol by volume, the ratio of solid to liquid was 8 times, and each time was 1 hour. The ethanol extract is concentrated, and the ethanol concentrate is recovered; the concentrate is added with an appropriate amount of water, and extracted twice with an equal volume of ethyl acetate; the ethyl acetate layer is concentrated, and the ethyl acetate concentrate is recovered to obtain a crude galangin extract.

[0039]② Add an appropriate amount of normal-phase silica gel to the obtained total crude extract, mix the sample and drain it, and place it on the top of a silica gel column for column chromatography separation, and use petroleum ether-ethyl acetate gradient elution;

[0040] ③The elution fractions were detected by thin-layer chromatography (the method is the same as above), and the fractions were merged according to the...

Embodiment 3

[0048] ①Galangal (Alpinia officinarum Hance) dried medicinal material was crushed into a coarse powder with a powder machine, extracted three times with 75% ethanol by volume, the ratio of solid to liquid was 6 times, and each time was 1 hour. The ethanol extract is concentrated, and the ethanol concentrate is recovered; the concentrate is added with an appropriate amount of water, and extracted twice with an equal volume of ethyl acetate; the ethyl acetate layer is concentrated, and the ethyl acetate concentrate is recovered to obtain a crude galangin extract.

[0049] ② Add an appropriate amount of normal-phase silica gel to the obtained total crude extract, mix the sample and drain it, and place it on the top of a silica gel column for column chromatography separation, and use petroleum ether-ethyl acetate gradient elution;

[0050] ③ The eluted fractions were detected by thin-layer chromatography (the method is the same as above). Merge fractions according to different rat...

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Abstract

The invention relates to a method for fully utilizing a traditional Chinese medicine material to prepare high-purity galangin. The method comprises the following steps that intermediates with similar constitution ratios are combined multiple times; and dextran chromatography and methanol recrystallization are carried out, such that high-purity galangin is obtained. Compared to prior arts, according to the invention, galangin and kaempferide in a galangal total crude extract are separated with the dextran chromatography and methanol recrystallization methods, such that galangin purity can reach 98-99.5%; through scientific and reasonable fraction combination design, low-purity fractions and crude products in the separation purification process can be repeatedly utilized. Therefore, the medicine material resource is fully utilized, cost is saved, and operation is convenient. With the method, it is possible to develop galangin into a medical raw material and especially a raw material medicine for traditional Chinese medicine injections and Chinese patent medicines.

Description

technical field [0001] The invention relates to a method for extracting and separating traditional Chinese medicine compounds, in particular to a method for extracting galangin so as to obtain high-purity galangin and directly use it in the application of pharmaceutical preparations. Background technique [0002] Galangal is the dried rhizome Chinese medicinal material of Zingiberaceae plant Galangal (Alpinia officinarum Hance). Since ancient times, as a traditional Chinese medicine that warms the stomach and dispels cold, regulates qi and relieves pain, it is often used clinically to treat symptoms such as epigastric cold pain, stomach cold vomiting, indigestion, belching and acid regurgitation. Galangal has complex chemical components and strong pharmacological activity. It has strong anti-ulcer, diarrhea, choleretic, analgesic, anti-inflammatory, anti-hypoxic, anti-coagulant, anti-thrombosis and other effects. Modern research on galangal is mainly focused on galangal vol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40
Inventor 叶青
Owner SHANGHAI U SEA BIOTECH
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