Clonidine hydrochloride sustained release pellets
A technology of clonidine hydrochloride and sustained-release pellets, which is applied in the direction of bulk delivery, medical preparations of non-active ingredients, cardiovascular system diseases, etc., can solve problems such as poor effect, stable blood pressure, and elevated blood pressure, and achieve The preparation method is simple and easy, the irritation is reduced, and the effect of individual differences is small
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Embodiment 1
[0034] A clonidine hydrochloride sustained-release pellet, comprising drug-containing pellets, an enteric coating layer, the enteric coating layer wraps the drug-containing pellets, and the drug-containing pellets include: 0.1mg clonidine hydrochloride, 180mg blank ball core, 10mg binder, the enteric coating layer includes: 45-225mg Eudragit NE30D, 7-68mg talcum powder.
[0035] The optimal mass ratio of the raw materials in the enteric coating layer is: 45mg Eudragit NE30D, 7mg talcum powder.
[0036] The binder is hypromellose.
[0037] The enteric coating layer also includes traces of sodium lauryl sulfate or polyethylene glycol.
Embodiment 2
[0039] A preparation method of clonidine hydrochloride sustained-release pellets, characterized in that: comprising the following steps:
[0040] Step 1: Prepare materials: according to the above mass ratio, take clonidine hydrochloride and hypromellose, and dissolve them with purified water;
[0041] Step 2: Pill making: take the blank pellet core, place it in the fluidized bed coating agent, put the dissolved raw material into the liquid supply tank, stir it from time to time, turn on the machine, adjust the parameters, and start coating. After the raw materials are used up, start to heat up to keep the material temperature above 40 degrees, dry for 30 minutes, cool down, discharge, and turn off the machine;
[0042] Step 3: Preparation of enteric coating agent: weigh Eudragit NE30D, talcum powder, sodium lauryl sulfate, and purified water according to the above mass ratio, first add sodium lauryl sulfate into the purified water and stir to dissolve , then add Eudra...
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