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A technology of clonidine hydrochloride and sustained-release pellets, which is applied in the direction of bulk delivery, medical preparations of non-active ingredients, cardiovascular system diseases, etc., can solve problems such as poor effect, stable blood pressure, and elevated blood pressure, and achieve The preparation method is simple and easy, the irritation is reduced, and the effect of individual differences is small
Inactive Publication Date: 2015-02-18
HARBIN SHENGJI PHARMA
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Problems solved by technology
[0015] At present, there are many medicines for treating hypertension on the market, but the effect of most medicines is not very good, and cannot completely reduce and stabilize blood pressure. Emotional changes or other reasons often lead to increased blood pressure, and there are many side effects of antihypertensive drugs on the market, such as headache, flushing, tachycardia, edema, mental depression and other symptoms
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Embodiment 1
[0034] A clonidine hydrochloride sustained-release pellet, comprising drug-containing pellets, an enteric coating layer, the enteric coating layer wraps the drug-containing pellets, and the drug-containing pellets include: 0.1mg clonidine hydrochloride, 180mg blank ball core, 10mg binder, the enteric coating layer includes: 45-225mg Eudragit NE30D, 7-68mg talcum powder.
[0035] The optimal mass ratio of the raw materials in the enteric coating layer is: 45mg Eudragit NE30D, 7mg talcum powder.
[0036] The binder is hypromellose.
[0037] The enteric coating layer also includes traces of sodium lauryl sulfate or polyethylene glycol.
Embodiment 2
[0039] A preparation method of clonidine hydrochloride sustained-release pellets, characterized in that: comprising the following steps:
[0040] Step 1: Prepare materials: according to the above mass ratio, take clonidine hydrochloride and hypromellose, and dissolve them with purified water;
[0041] Step 2: Pill making: take the blank pellet core, place it in the fluidized bed coating agent, put the dissolved raw material into the liquid supply tank, stir it from time to time, turn on the machine, adjust the parameters, and start coating. After the raw materials are used up, start to heat up to keep the material temperature above 40 degrees, dry for 30 minutes, cool down, discharge, and turn off the machine;
[0042] Step 3: Preparation of enteric coating agent: weigh Eudragit NE30D, talcum powder, sodium lauryl sulfate, and purified water according to the above mass ratio, first add sodium lauryl sulfate into the purified water and stir to dissolve , then add Eudra...
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Abstract
The invention provides clonidine hydrochloride sustained release pellets. The clonidine hydrochloride sustained release pellets comprise medicine-containing pellets and enteric coating layers, wherein the medicine-containing pellets are coated by the enteric coating layers; the medicine-containing pellets comprise 0.1mg of clonidine hydrochloride, 180mg of hollow pellet cores and 10mg of adhesive; the enteric coating layers comprise 45-225mg of Eudragit NE30D and 7-68mg of talcum powder. A preparation method of the clonidine hydrochloride sustained release pellets comprises the following processes: 1. material preparation; 2. pellet preparation; 3. preparation of an enteric coating agent; 4. coating; 5. filling; 6. aluminium-plastic packaging and preparation of finished products. The sustained release pellets with clonidine hydrochloride as an active ingredient are mainly used for treating hypertension and have the beneficial effects that as the two kinds of advanced technologies, namely novel sustained release preparations and pellet preparations, are adopted, the clonidine hydrochloride sustained release pellets have stable treatment effects and higher bioavailability and have the advantages of good medicine stability, convenience in packaging, transportation and storage, and the like. The preparation method is simple and practicable and is suitable for industrial production.
Description
technical field [0001] The invention belongs to the field of chemical drug sustained-release preparations, and in particular relates to a clonidine hydrochloride sustained-release pellet and a preparation method thereof. Background technique [0002] Hypertension is defined as elevated arterial systolic and / or diastolic blood pressure at rest. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. There are many reasons for the onset of hypertension, which can be divided into two aspects: genetic and environmental. [0003] Normal red blood cells and colloidal particles are negatively charged, and they repel each other and keep a certain distance, while diseased and aging red blood cells are positively charged due to competition for electrons, and the red blood cells a...
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