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Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation

A mixing system and equipment technology, which is applied in the direction of making medicines into special physical or ingestible devices, can solve the problems of long granulation time, poor physical and chemical properties of granules, and low dispersion of viscous materials, so as to avoid safety Hidden dangers, reasonable particle size distribution, and short granulation time

Inactive Publication Date: 2015-02-25
HANGZHOU ZHONGMEI HUADONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a mixing and granulating equipment to solve the problems of potential safety hazards in the prior art, and to solve the problem of low dispersion of viscous materials, which leads to too long granulation time and poor physical and chemical properties of the prepared granules and other technical defects

Method used

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  • Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation
  • Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation
  • Mixed granulating equipment and application of mixed granulating equipment for preparing solid preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of capecitabine sheet

[0037] A mixing and granulation equipment, such as figure 1 and figure 2 As shown, it includes a pressure tank 2 and a mixing granulator 8, the pressure tank 2 is placed on the left side of the mixing granulator 8, the upper part is equipped with a compressed air interface 1, and the bottom is equipped with a connecting hose 3, and the connecting soft The pipe 3 is used to connect the pressure tank 2 and the mixing granulator 8; it also includes a shower 5 placed on the middle and upper part of the mixing granulator 8, connected to the connecting hose 3 through the connecting pipe 4, and the shower 5 is A hollow cylinder with circular holes 9 on the top, which are circularly distributed on the top of the shower head 5. There are 50 holes 9 with a diameter of 2 mm. Used between the shower head 5 and the connecting pipe 4 Threaded connection, the connecting pipe 4 and the connecting hose 3 are connected by a clamp f...

Embodiment 2

[0048] Embodiment 2: the preparation of moxifloxacin hydrochloride tablet

[0049] The connection mode of the mixing and granulating equipment of embodiment 2 is the same as that of embodiment 1, the difference is:

[0050] There are circular holes 9 on the top of the shower 5, distributed in a circle on the top of the shower 5, and there are 70 holes 9 with a diameter of 1.0 mm.

[0051] The production process of moxifloxacin hydrochloride tablets is as follows: add 3.4kg of moxifloxacin hydrochloride, 0.9kg of pregelatinized starch, 0.6kg of microcrystalline cellulose, and 0.15kg of croscarmellose sodium into the HLSG20A mixing granulator , turn on the stirring speed of 150rpm, the chopping speed of 1300rpm, and mix well. Use water as a wetting agent for wet granulation, then dry and granulate; add an appropriate amount of magnesium stearate, mix evenly, compress into tablets, and coat.

[0052] When working, add water to the pressure tank 2, adjust the opening of the comp...

Embodiment 3

[0058] Embodiment 3: the preparation of Bailing Tablet

[0059] The connection mode of the mixing and granulating equipment of embodiment 3 is the same as that of embodiment 1, the difference is:

[0060] There are square holes 9 on the top of the shower 5, which are circularly distributed on the top of the shower 5. There are 80 holes 9 with a diameter of 1.5mm.

[0061] The production process of Bailing Tablets is as follows: Add 30kg of fermented Cordyceps sinensis powder, 5kg of pregelatinized starch, and 4kg of microcrystalline cellulose into the SHK-220A mixing granulator, turn on the stirring "Ⅰ" file, chop " Ⅰ” level, mix evenly. 10% hydroxypropyl cellulose ethanol solution is used as a binder for wet granulation, then dried and sized; an appropriate amount of magnesium stearate is added to mix evenly, and the tablet is obtained.

[0062] During work, 10% hydroxypropyl cellulose ethanol solution is added in the pressure tank 2, and the opening degree of the compresse...

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Abstract

The invention discloses granulating equipment. The granulating equipment comprises a pressure tank and a mixed granulating machine, the pressure tank is arranged on the left side of the mixed granulating machine, the upper portion of the pressure tank is provided with a compressed air connector, the bottom of the pressure tank is provided with a connection hose, and the connection hose is used for being connected with the pressure tank and the mixed granulating machine. The granulating equipment further comprises a sprinkler, the top of the sprinkler is provided with holes, and the sprinkler is arranged on the upper half portion of the mixed granulating machine and is connected with the connection hose through a connection pipe. The granulating equipment is suitable for preparing solid preparations like capecitabine tablets, moxifloxacin hydrochloride tablets, Letrozol tablets, anastrozole tablets, repaglinide tablets, acarbose chewable tablets and tacrolimus capsules. The granulating equipment is easy and convenient to operate; the prepared particles are good in mobility and compressibility; the manufactured preparations are smooth and attractive in appearance and free of spots on surfaces, meanwhile, the quality indexes like disintegration time, the dissolution rate and the content uniformity all accord with or exceed inner quality standards, and finally the solid preparations with good quality can be obtained.

Description

technical field [0001] The invention relates to a granulation equipment, in particular to a mixing granulation equipment and its application in the preparation of solid preparations. Background technique [0002] Mixing granulation is the most commonly used granulation method in the production of solid dosage forms. The way of adding the materials used in granulation is basically through a thicker pipe directly, or by using a spray gun. [0003] The way of adding materials in the prior art has the following defects: [0004] 1. Adding materials in a thick tube is easy to gather at the powder and not easy to disperse, which will prolong the granulation time and affect the properties of the granules. If the added material is relatively viscous, adding in a thick tube will significantly affect the properties of the granules, resulting in The particles form agglomerates, which affects the content uniformity and dissolution rate of the product, and even the subsequent process s...

Claims

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Application Information

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IPC IPC(8): A61J3/00
Inventor 姚忠立张洪记鄢丰胡瑞斌姚斌
Owner HANGZHOU ZHONGMEI HUADONG PHARMA
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