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Fevervine extract and applications thereof

A kind of extract, the technology of vine vine, which is applied in the field of vine vine extract, can solve the problems of cumbersome operation and high energy consumption, and achieve the effect of less dosage, high yield and simple process

Active Publication Date: 2015-03-11
NINGBO DACHANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method disclosed in this application is cumbersome to operate and has high energy consumption.

Method used

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  • Fevervine extract and applications thereof
  • Fevervine extract and applications thereof
  • Fevervine extract and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 1.0kg of Yunnan medicinal materials (batch number: 131110), add 8 times the amount of 95% ethanol to reflux for extraction for 3 hours, extract 3 times, filter and combine the extracts, concentrate under reduced pressure at 60°C until there is no alcohol smell, add deionized water to 4L to make Dissolve, centrifuge, take the D101 macroporous adsorption resin on the supernatant (the ratio of the amount of medicinal material to the resin is that 1kg of medicinal material requires 300ml of D101 macroporous resin after swelling and pretreatment with absolute ethanol), the diameter-to-height ratio of the resin column is 1:8, The sample loading flow rate is 1.0BV / h. After the sample loading, the elution flow rate is 5BV / h. First, use deionized water to elute the resin column 2BV, discard the flow-through liquid and water eluent, and then wash with 85% ethanol. De-resin column 6BV, collect the eluate of 85% ethanol, concentrate under reduced pressure at 60°C, and dry to ob...

Embodiment 2

[0031] Take 1.0 kg of Yunnan medicinal materials (batch number: 131226), add 8 times the amount of 95% ethanol to reflux for extraction for 3 hours, extract 3 times, filter and combine the extracts, concentrate under reduced pressure at 60 ° C until there is no alcohol smell, add deionized water to 4 L Dissolve, centrifuge, take the D101 macroporous adsorption resin on the supernatant (the ratio of the amount of medicinal material to the resin is that 1kg of medicinal material requires 300ml of D101 macroporous resin after swelling and pretreatment with absolute ethanol), the diameter-to-height ratio of the resin column is 1:8, The sample loading flow rate is 1.0BV / h. After the sample loading, the elution flow rate is 5BV / h. First, use deionized water to elute the resin column 2BV, discard the flow-through liquid and water eluent, and then wash with 85% ethanol. De-resin column 6BV, collect the eluate of 85% ethanol, concentrate under reduced pressure at 60°C, and dry to obtain...

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Abstract

The invention discloses a fevervine extract and applications thereof. The extract contains iridoid glycoside compounds, which are characterized by being composed of the following components in percentage by weight: 20.0 to 50.0% of paederosidic acid, 2.0 to 25.0% of paederoside, and 1.0 to 10.0% of methyl paederosidate. The fevervine extract is prepared by the following steps: (a) using ethanol to extract fevervine herb so as to obtain an extract solution; (b) condensing the extract solution until no ethanol fragrance can be smelled, then carrying out macroporous resin chromatography on the extract solution, eluting the resin by water and ethanol (80-90%) in sequence, collecting the eluents, and drying under reduced pressure so as to obtain the fevervine extract. The invention further provides applications of the fevervine extract in preparation of drugs for treating and preventing kidney damages.

Description

technical field [0001] The present invention relates to an extract of vine vine and its use. Background technique [0002] Chicken Yateng is the above-ground part or whole plant of Rubiaceae Paederia scandens (Lour.) Merr. It is a traditional Chinese herbal medicine, also known as chicken shit rattan, cowhide jelly, Jieshu rattan, bullshit rattan, smelly rattan, breeze Rattan, etc., Cercis japonica tastes glucoside, flat in nature, enters the liver, stomach, and large intestine meridians, and has the effects of eliminating food accumulation, dispelling wind and activating blood circulation, relieving pain and reducing swelling. Distributed in many countries in China and Southeast Asia, domestic and foreign studies on the pharmacological effects and clinical application of Gallus vine mainly focus on anti-inflammatory, analgesic and treatment of digestive system diseases. In recent years, the chemical composition studies have shown that Sagittaria mainly contains sulfur-cont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P19/06A61P13/12A61P19/02
CPCA61K31/7048A61K36/74A61K2236/333A61K2236/51A61K2300/00
Inventor 吴彤沈幸光沈龙海周海凤李默影乐心逸张乐乐颜仁杰张雪张美璇王娴娴孙艳
Owner NINGBO DACHANG PHARMA
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