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Traditional Chinese medicine preparation treating femur head necrosis and preparation technology thereof

A technology of femoral head necrosis and traditional Chinese medicine preparations, which is applied in the field of medicine, can solve the problems of unsatisfactory treatment speed and disease radical cure, and achieve the effect of good physical conditioning of patients, less toxic and side effects, and enhanced disease resistance

Inactive Publication Date: 2015-03-11
崔新明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicines made by these methods all have a certain effect on relieving symptoms, but they are mostly unsatisfactory in terms of the speed of the course of treatment and the radical cure of the disease.

Method used

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  • Traditional Chinese medicine preparation treating femur head necrosis and preparation technology thereof
  • Traditional Chinese medicine preparation treating femur head necrosis and preparation technology thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] According to the actual production of Chinese medicine capsules by the Chinese medicine prescription of the present invention, the capsule numbering A is the optimal scheme proportioning preparation, and the capsule numbering B and C are the minimum and maximum range proportioning preparations of the prescription, and the proportioning ratio of every kind of capsule raw materials is shown in Table 1. Show.

[0031] Table 1 Raw material ratio of capsules (unit: g)

[0032]

[0033] The preparation of Chinese medicine composition:

[0034] Step 1. According to the traditional Chinese medicine prescription in Table 1, weigh 12 medicinal materials of rehmannia glutinosa, cornus officinalis, wolfberry, white mustard seed, safflower, myrrh, ulmoides, dodder, aconite, angelica, evening primrose, and earth element, crush them separately, and mix them. Add 60% ethanol that is 6 times the weight of the medicinal material, heat and reflux for 2 hours, and filter; add 60% ethan...

Embodiment 2

[0039] Embodiment 2, the animal toxicity test of Chinese medicine capsule of the present invention

[0040] (1) Test drug: the traditional Chinese medicine capsule prepared in Example 1 of the present invention, the capsule shell was broken, and the medicinal powder was prepared into a thin paste with purified water, and set aside.

[0041] Animals used in the test: normal grade NIH mice, weighing 21g±6g, half male and half female, all female mice were sterile; SD rats, initial weight 218±9g, half male and half female, all female rats were sterile.

[0042] (2) Acute toxicity test

[0043] Application of mice to carry out acute toxicity test shows: mice gavage Chinese medicine dilute paste of the present invention, under 45g crude drug / kg dose, after administration, mice occur slight activity reduction, return to normal in about 1 hour, observe continuously after administration for 7 days. On the first day, none of the mice died, and the general condition, diet, water intake,...

Embodiment 3

[0048] Clinical effect test of Chinese medicine capsule of the present invention

[0049] 1. Source and grouping of subjects

[0050] All the subjects were from a city people's hospital, patients with femoral head necrosis who were treated from May 2011 to October 2013 (patients showed: ① Pain. Pain can be intermittent or persistent, aggravated after walking, sometimes It is rest pain. The pain is mostly acupuncture-like, dull pain or soreness and discomfort, and often radiates to the groin area, inner thigh, back of the hip and inner knee, and has numbness in this area. ② Joint stiffness and limited mobility. Unfavorable hip flexion and extension, difficulty in squatting, inability to stand for a long time, and walking duck steps. The early symptoms are obvious limitation of abduction and external rotation. ③ Limping. It is progressive shortening claudication, due to hip pain and femoral head collapse, or Caused by hip subluxation in the late stage. Intermittent claudication...

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Abstract

The invention discloses a traditional Chinese medicine preparation treating femur head necrosis and a preparation technology thereof. The traditional Chinese medicine preparation is prepared from radix rehmanniae preparata, fructus corni, barbary wolfberry fruit, white mustard seed, flos carthami, myrrh, cortex eucommiae, semen cuscutae, prepared common monkshood daughter root, radix angelicae sinensis, root of redsepal eveningprimrose, deerhorn glue, ground beetle and other traditional Chinese medicinal materials through a conventional pharmaceutical preparation technology. The traditional Chinese medicine preparation has extremely substantial treatment effect on femur head necrosis, and also is simple in preparation technology, good in stability, convenient to carry and take, and easy to popularize and apply.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine preparation for treating femoral head necrosis and a preparation process thereof. technical background [0002] Femoral head necrosis is often called avascular necrosis of the femoral head or aseptic necrosis of the femoral head because its main pathology is the obstruction of the blood supply of the femoral head and the bone ischemia caused by the destruction of the femoral head. The common types are: steroid-induced femoral head necrosis, alcohol-induced femoral head necrosis, traumatic femoral head necrosis, elderly femoral head necrosis, and children's femoral head necrosis. In recent years, the incidence of femoral head necrosis has gradually increased, and the age of onset has gradually decreased. The main clinical manifestations of femoral head necrosis are hip pain, claudication, and joint dysfunction, and then further develop into femoral...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P19/08A61K35/32A61K35/64
CPCA61K35/32A61K36/185A61K36/232A61K36/286A61K36/31A61K36/328A61K36/39A61K36/40A61K36/46A61K36/714A61K36/804A61K36/815A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 崔新明
Owner 崔新明
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