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Spherical calcium citrate, and preparation method and application thereof

A technology of calcium citrate and citrate, which is applied in the direction of carboxylate preparation, carboxylate preparation, chemical instruments and methods, etc., can solve the problem of no spherical calcium citrate, etc., and achieve the purpose of expanding the scope of application and expanding the application field Effect

Active Publication Date: 2015-03-11
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The currently used calcium citrate is in the form of flakes and powders, and there is no report on spherical calcium citrate

Method used

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  • Spherical calcium citrate, and preparation method and application thereof
  • Spherical calcium citrate, and preparation method and application thereof
  • Spherical calcium citrate, and preparation method and application thereof

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preparation example Construction

[0028] The present invention also provides the preparation method of the above-mentioned spherical calcium citrate, water-soluble calcium salt and water-soluble citrate are mixed with water to obtain a mixed aqueous solution of calcium salt and citrate, and the mixed aqueous solution of calcium salt and citrate is mixed at 40 Heating and stirring at -99°C for 2min-30min, separating the obtained solid-liquid mixture into solid-liquid, washing and drying to obtain spherical calcium citrate; wherein, in the mixed aqueous solution of calcium salt and citrate, by molar ratio, calcium ion: lemon Acid radical > 2.5:2; preferably, calcium ion: citrate = 2.8-8:2; more preferably, calcium ion: citrate = 2.8-3.2:2.

[0029] In the present invention, calcium citrate can be separated out in the calcium salt-citrate solution above 40 degrees, because calcium salt and citrate are all dissolved in water, so the temperature generally cannot exceed the boiling point of water; if the temperature ...

Embodiment 1

[0038] Weigh 0.8670 g of CaCl respectively 2 , 1.4854 g Na 3 C 6 h 5 o 7 2H 2 O, add 20ml water to dissolve in the beaker; Na 3 C 6 h 5 o 7 2H 2 O solution was added to CaCl 2 , stir evenly; put the beaker with the mixed solution into the water bath, the water bath temperature is 75 degrees Celsius, and the stirring speed is set to 20r / min; take out the beaker after 2 minutes, add distilled water to the beaker and cool to room temperature (due to the temperature from 75 degrees Celsius The natural cooling time is relatively slow, which is too long compared to the 2min of the water bath. In order to make the reaction end quickly, cold water is added to cool down quickly); filtration, solid-liquid separation, washing of the solid for 3 times and then freeze-drying can obtain self-assembled spherical citric acid Calcium, its SEM image is shown in figure 1 shown; its diameter is 10-20 microns. Its specific surface area is 1.737m2 using the BET method 2 / g. The XRD fi...

Embodiment 2

[0040] Weigh 0.8670 g of CaCl respectively 2 , 1.4854 g Na 3 C 6 h 5 o 7 2H 2 O, add 20ml water to dissolve in the beaker; Na 3 C 6 h 5 o 7 2H 2 O solution was added to CaCl 2 solution, stir evenly; put the beaker containing the mixed solution into a water bath, the temperature of the water bath is 75 degrees Celsius, and the stirring speed is set to 20r / min; take out the beaker after 5 minutes, add distilled water to the beaker and cool to room temperature; filter, solidify Liquid separation, the solid was washed 3 times and then freeze-dried to obtain self-assembled spherical calcium citrate, whose diameter was 10-20 microns as shown by its SEM image. Its specific surface area is 50.824m2 using the BET method 2 / g.

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Abstract

The invention belongs to the field of calcium citrate, and concretely relates to spherical calcium citrate, and a preparation method and application thereof. The provided calcium citrate is spherical, has the diameter of 10-100 mu m and has the specific surface area of 1-80 m<2> / g determined by a BET method. The prepared spherical calcium citrate is calcium citrate with a new morphology never reported before, calcium citrate, which is extremely good in biocompatibility, is endowed with new performances, and the application scope of calcium citrate is expanded. The foreseeable thing is that if the morphology of calcium citrate can be effectively controlled and calcium citrate powders with diversified morphologies can be obtained, calcium citrate powders with different properties can be obtained and the application fields of calcium citrate can be expanded.

Description

technical field [0001] The invention belongs to the field of calcium citrate, in particular to a spherical calcium citrate and its preparation method and application. Background technique [0002] Calcium citrate is an organic calcium salt with very good biocompatibility. Due to its advantages of being easily absorbed by the human body and non-toxic, calcium citrate is often used as a calcium supplement to treat calcium deficiency diseases such as osteoporosis. Calcium citrate is generally obtained by neutralization titration of calcium hydroxide and citric acid or the reaction of calcium carbonate and citric acid. The focus is on cheap and cheap raw materials for commercial production, but the morphology and crystallization of calcium citrate are not controlled. Such as Chinese patent application 200710021894.2 "A method for quickly extracting soluble calcium citrate by using potato dregs", which uses Aspergillus niger to ferment potato dregs to obtain citric acid, which is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41C07C51/42A61K47/12A61L27/00
CPCA61K47/12A61L27/00C07C51/412C07C59/265
Inventor 李峻峰钟良兆侯毅赖雪飞邱克辉李冠玉黄露梅
Owner CHENGDU UNIVERSITY OF TECHNOLOGY
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