Gold nanoparticle flower or quantum dot composite probe for living cell immunofluorescent labeling and photothermal treatment

A technology of gold nanoflowers and composite probes, which is used in nanotechnology, fluorescence/phosphorescence, nanotechnology, etc. for materials and surface science, and can solve the problem of difficult control of composite probes, large absorption spectrum width, and difficulty in controlling consistency etc. to achieve high photothermal conversion efficiency, enhanced fluorescence intensity, and avoidance of biological toxicity
CN104416152AInactive Publication Date: 2015-03-18THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
Publication Date
2015-03-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides are a gold nanoflower structure and a preparation method therefor. The gold nanoflower structure is a gold nanoflower particle, with round-head columns being uniformly distributed at the periphery thereof, obtained by using gold octahedrons, gold balls or gold tetrahedrons as seed crystals and reducing chloroauric acid by using weak reductant in an environment of high-concentration polyvinylpyrrolidone. In addition, also provided in the present invention are a gold nanoflower / quantum dot composite probe for living cell immunofluorescent labeling and photothermal therapy, a preparation method therefor and a use thereof. In comparison with traditional probes, the probe, incorporates the features of photothermal therapy and fluorescent labeling, and is capable of killing cancer cells in an effective and directional way. Two light sources are adopted to bring a tremendous photothermal conversion efficiency and a greater enhancement on fluorescence intensity of quantum dots respectively, thus mutual interference of two effects are avoided tactfully. The coating of silicon dioxide averts the biotoxicity of the gold nanoflower and the quantum dot effectually, enabling the surface of the composite probe to be easily functionalized and also imparting an extraordinarily excellent biocompatibility to the composite probe.
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Description

technical field

[0001] The invention relates to the technical field of composite nanoprobes, in particular to a gold nanoflower / quantum dot composite probe for immunofluorescence labeling and photothermal treatment of living cells. Background technique

[0002] Quantum dots are nanomaterials artificially synthesized by a small number of atoms, also known as "artificial atoms". After being excited, they can emit fluorescence, change the structure of quantum dots, and adjust their excitation and emission wavelengths at will. It is used to label and locate the target cells after the specific antibody is activated, and maintain its physicochemical and luminescence stability in the cells for a long time. Replacing traditional dyes with quantum dots as fluorescent markers can overcome the disadvantages of large dye molecules (thus needing to make holes in cells and cannot be used for in vivo labeling), poor photochemical stability and spectral characteristics, and can be used for ...

Claims

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