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A kind of medicine for the prevention and treatment of ischemic stroke and its preparation method

A technology for ischemic stroke and drugs, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as difficult prevention and treatment of stroke recurrence, and improve neuromuscular function and vestibular motor function , reduced infarct size, and easy industrialization

Active Publication Date: 2018-01-05
罗国安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Ischemic stroke is a multi-link injury cascade reaction. Ischemia triggers excitotoxicity, peri-infarct depolarization, inflammation and programmed cell death, leading to neuronal damage and neurological dysfunction. This is cerebral ischemic injury. The main pathophysiological mechanism of the ischemic stroke. At present, the antiplatelet drugs and anticoagulants and other chemical drugs used clinically to prevent and treat ischemic stroke mostly act on a certain link or a certain target of the stroke-ischemic cascade reaction, and it is difficult to fundamentally prevention and treatment of stroke recurrence

Method used

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  • A kind of medicine for the prevention and treatment of ischemic stroke and its preparation method
  • A kind of medicine for the prevention and treatment of ischemic stroke and its preparation method
  • A kind of medicine for the prevention and treatment of ischemic stroke and its preparation method

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Embodiment 1

[0044] The medicine for the prevention and treatment of ischemic stroke in this embodiment is composed of escutellaria extract, ginseng extract and Radix Ophiopogon japonicus extract, wherein, the preparation method of Erigeron breviscapus extract, ginseng extract and Ophiopogon japonicus extract as follows:

[0045] 1. Preparation of Erigeron breviscapus extract

[0046] Accurately weigh 10 kg of breviscapine asarum coarse powder, add 80 L of ethanol with a volume percentage of 75%, soak for 30 minutes, and then carry out reflux extraction for 60 minutes; collect the extract, and then add 80 L to the residue for a volume of 100 75% ethanol was used for reflux extraction, and the extraction time was 60 minutes; the above extraction process was repeated once. Mix the three extracts, cool to room temperature, filter, take the filtrate and concentrate under reduced pressure (60°C, vacuum degree 0.08Mpa) until it has no alcohol smell, and obtain 2.3kg of extract; take 2.3kg of ex...

Embodiment 2

[0061] The preparation method of Erigeron breviscapus extract, ginseng extract and Ophiopogon japonicus extract is the same as in Example 1. Mix 1 g of Erigeron breviscapus extract powder prepared in the above step 1, 20 g of the ginseng extract powder prepared in the above step 2, and 20 g of the total saponin extract powder of Ophiopogon japonicus prepared in the above step 3 to obtain the medicine of the present invention.

Embodiment 3

[0063] The preparation method of Erigeron breviscapus extract, ginseng extract and Ophiopogon japonicus extract is the same as in Example 1. Mix 200g of the scutellaria extract powder prepared in the above step 1, 10g of the ginseng extract powder prepared in the above step 2, and 10g of the Ophiopogon japonicus extract powder prepared in the above step 3 to obtain the medicine of the present invention.

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Abstract

The invention relates to the field of traditional Chinese medicines and particularly relates to a medicine for preventing and treating ischemic cerebral apoplexy and a preparation method thereof. The medicine is prepared from erigeron breviscapus, ginseng and / or red ginseng and radix ohiopogonis in a weight ratio of 1:(0.08-10):(0.08-10). Furthermore, the medicine is prepared from an erigeron breviscapus extract, a ginseng and / or red ginseng extract and a radix ohiopogonis extract in a weight ratio of 1:(0.05-20):(0.05-20). The preparation method comprises the following steps: soaking; carrying out reflux extraction; adsorbing by using a macroreticular resin column; drying; and mixing. The medicine is simple in component and remarkable in curative effect and can prevent and treat relapse of ischemic cerebral apoplexy fundamentally. The method achieves a relatively good curative effect with relatively few raw materials, so that the utilization ratio of the erigeron breviscapus medicinal material is greatly improved, and the medicine is simple in production step, convenient to operate, easy for industrialization and low in production cost.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for the prevention and treatment of ischemic cerebral apoplexy and a preparation method thereof. Background technique [0002] Ischemic stroke refers to the disorder of blood supply to the brain caused by various reasons, causing irreversible damage to the local brain tissue, resulting in ischemia and hypoxic necrosis of the brain tissue, causing corresponding neurological symptoms and signs. It is one of the three major diseases that cause human death due to the characteristics of high morbidity rate, high mortality rate, high disability rate and high recurrence rate. According to MONICA survey data, the recurrence rate of ischemic stroke in my country is as high as 30%, ranking first in the world. Since recurrent stroke can lead to more serious disability and death, preventing patients with a history of stroke from recurring, that is, "secondary preventio...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P9/10
CPCA61K36/258A61K36/28A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 罗国安王义明
Owner 罗国安
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