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Moldable autogenous bone mud and preparation method thereof

An autologous bone, plastic technology, applied in the direction of prosthesis, medical science, etc., can solve the problem that the volume of bone powder cannot meet the reconstruction of the cavity, the effect of the reconstruction of the surgical area, and increase the risk of secondary surgery, so as to reduce the surface activity of platelets. , the effect of inhibiting platelet aggregation and adhesion, reducing the risk of secondary surgery

Inactive Publication Date: 2014-03-05
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Autologous bone powder is the most commonly used material for mastoid cavity filling in clinical practice. Autologous bone powder is considered by many scholars as the best choice for mastoid cavity filling material. It has the advantages of convenient material extraction, good osteogenesis and osteoconductivity, and low immune reactivity. However, in the process of actual operation and postoperative follow-up of patients, we found that the application of autologous bone powder still has shortcomings. Second, the autologous bone powder is difficult to be fixed well, and it is easy to flow during and after the operation and lead to infection in the operation area, excessive granulation tissue hyperplasia, and dry ears. Prolonged time may even increase the risk of secondary surgery
Moreover, the autologous bone powder used in the operation must be detected by the operating microscope as a healthy bone powder. If there are lesions mixed in the bone powder, such as cholesteatoma epithelium, granulation tissue, etc., the bone powder will be discarded. Therefore, the collected bone powder capacity cannot Meet the needs of reconstruction surgery cavity

Method used

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  • Moldable autogenous bone mud and preparation method thereof
  • Moldable autogenous bone mud and preparation method thereof
  • Moldable autogenous bone mud and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A moldable autologous bone paste, which includes the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution;

[0043] In this example, the volume ratio of autologous bone powder, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:1:1;

[0044] In this example, the volume ratio of the calcium chloride solution to the mixture of Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:4, and the mass percent concentration of the calcium chloride solution in this example is 5%. The purity of the Panax notoginseng saponins powder of embodiment is 85%. The Panax notoginseng saponins powder used in this example was provided by Nanjing Jingzhu Biotechnology Co., Ltd.

[0045]The above-mentioned preparation method of a moldable autologous bone paste comprises the following steps:

[0046] Step 1. Preparation of human cryo...

Embodiment 2

[0053] A moldable autologous bone paste, which includes the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution;

[0054] In this example, the volume ratio of autologous bone powder, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1.5:2:1.5;

[0055] In this example, the volume ratio of the calcium chloride solution to the mixture of Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:3, and the mass percent concentration of the calcium chloride solution in this example is 4%. The purity of the Panax notoginseng saponins powder of embodiment is 80%.

[0056] The above-mentioned preparation method of a moldable autologous bone paste comprises the following steps:

[0057] Step 1. Preparation of human cryoprecipitate freeze-dried powder: vacuum freeze-dry human cryoprecipitate at -55°C for 9 hours to obtain human c...

Embodiment 3

[0064] A moldable autologous bone paste, which includes the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution;

[0065] In this example, the volume ratio of autologous bone powder, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 2:1.5:1.5;

[0066] In this example, the volume ratio of the calcium chloride solution to the mixture of Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:5, and the mass percentage concentration of the calcium chloride solution in this example is 6%. The purity of the Panax notoginseng saponins powder of embodiment is 90%.

[0067] The above-mentioned preparation method of a moldable autologous bone paste comprises the following steps:

[0068] Step 1. Preparation of human cryoprecipitate freeze-dried powder: vacuum freeze-dry human cryoprecipitate at -57°C for 7 hours to obtain huma...

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Abstract

The invention relates to the technical field of cavity filling composite materials, and specifically relates to moldable autogenous bone mud and a preparation method thereof. The moldable autogenous bone mud comprises the following components: autogenous bone powder, powder of total saponin of panax notoginseng, human cryoprecipitate freeze-dried powder and calcium chloride liquor, wherein the volume ratio of the autogenous bone powder, the powder of total saponin of panax notoginseng to the human cryoprecipitate freeze-dried powder is (1-2):(1-2):(1-2). The preparation method of the moldable autogenous bone mud comprises the following steps: uniformly mixing the powder of total saponin of panax notoginseng and the human cryoprecipitate freeze-dried powder both radiated by a Co60-gamma ray; then, adding the calcium chloride liquor; uniformly mixing; and then uniformly mixing with the autogenous bone powder to obtain the moldable autogenous bone mud. The moldable autogenous bone mud provided by the invention has the advantages of easiness in molding, good molding effect, easiness for being fixed and good bacteriostatic action, and can promote healing of a postoperative area of mastoidectomy, so that the wound is quick to heal and smooth.

Description

Technical field [0001] The invention involves the field of composite materials in the field of surgery, which specifically involves a method of shaping autologous bone mud and its preparation methods. Background technique [0002] In medical clinical clinical, ototic lesions, such as chronic purulent otitis media, are surgical indications for mastoid root treatment combined with drum composition.However, due to the large surgery, the surgery is large, and there are unsatisfactory hearing recovery in the surgery. The postoperative recovery time, low ear rate, and high recurrence rate.Therefore, the vast majority of otologists at home and abroad proposes that the dilute cavity can be used as one of the important steps of mastoid root treatment. [0003] The autologous bone powder, as the most commonly used dilute cavity filling material in the clinic, is considered by many scholars to be the best choice for complication materials of the pause cavity.Advantages, but in the process o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/54
Inventor 陈锡辉邹义婷
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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