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Moldable autogenous bone mud and preparation method thereof

An autologous bone, plastic technology, applied in the direction of prosthesis, medical science, etc., can solve the problem that the volume of bone powder cannot meet the reconstruction of the cavity, the effect of the reconstruction of the surgical area, and increase the risk of secondary surgery, so as to reduce the surface activity of platelets. , the effect of inhibiting platelet aggregation and adhesion, reducing the risk of secondary surgery

Inactive Publication Date: 2015-05-20
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Autologous bone powder is the most commonly used material for mastoid cavity filling in clinical practice. Autologous bone powder is considered by many scholars as the best choice for mastoid cavity filling material. It has the advantages of convenient material extraction, good osteogenesis and osteoconductivity, and low immune reactivity. However, in the process of actual operation and postoperative follow-up of patients, we found that the application of autologous bone powder still has shortcomings. Second, the autologous bone powder is difficult to be fixed well, and it is easy to flow during and after the operation and lead to infection in the operation area, excessive granulation tissue hyperplasia, and dry ears. Prolonged time may even increase the risk of secondary surgery
Moreover, the autologous bone powder used in the operation must be detected by the operating microscope as a healthy bone powder. If there are lesions mixed in the bone powder, such as cholesteatoma epithelium, granulation tissue, etc., the bone powder will be discarded. Therefore, the collected bone powder capacity cannot Meet the needs of reconstruction surgery cavity

Method used

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  • Moldable autogenous bone mud and preparation method thereof
  • Moldable autogenous bone mud and preparation method thereof
  • Moldable autogenous bone mud and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A moldable autologous bone paste, which includes the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution;

[0043] In this example, the volume ratio of autologous bone powder, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:1:1;

[0044] In this example, the volume ratio of the calcium chloride solution to the mixture of Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:4, and the mass percent concentration of the calcium chloride solution in this example is 5%. The purity of the Panax notoginseng saponins powder of embodiment is 85%. The Panax notoginseng saponins powder used in this example was provided by Nanjing Jingzhu Biotechnology Co., Ltd.

[0045]The above-mentioned preparation method of a moldable autologous bone paste comprises the following steps:

[0046] Step 1. Preparation of human cryo...

Embodiment 2

[0053] A moldable autologous bone paste, which includes the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution;

[0054] In this example, the volume ratio of autologous bone powder, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1.5:2:1.5;

[0055] In this example, the volume ratio of the calcium chloride solution to the mixture of Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:3, and the mass percent concentration of the calcium chloride solution in this example is 4%. The purity of the Panax notoginseng saponins powder of embodiment is 80%.

[0056] The above-mentioned preparation method of a moldable autologous bone paste comprises the following steps:

[0057] Step 1. Preparation of human cryoprecipitate freeze-dried powder: vacuum freeze-dry human cryoprecipitate at -55°C for 9 hours to obtain human c...

Embodiment 3

[0064] A moldable autologous bone paste, which includes the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution;

[0065] In this example, the volume ratio of autologous bone powder, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 2:1.5:1.5;

[0066] In this example, the volume ratio of the calcium chloride solution to the mixture of Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder is 1:5, and the mass percentage concentration of the calcium chloride solution in this example is 6%. The purity of the Panax notoginseng saponins powder of embodiment is 90%.

[0067] The above-mentioned preparation method of a moldable autologous bone paste comprises the following steps:

[0068] Step 1. Preparation of human cryoprecipitate freeze-dried powder: vacuum freeze-dry human cryoprecipitate at -57°C for 7 hours to obtain huma...

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Abstract

The invention relates to the technical field of operation cavity packing composite materials, in particular to a shapeable autologous bone cement and a preparation method thereof. A plastic autologous bone paste, including the following components: autologous bone powder, Panax notoginseng saponins powder, human cryoprecipitate freeze-dried powder, calcium chloride solution; wherein, autologous bone meal, Panax notoginseng saponins powder and human cryoprecipitate freeze-dried powder The volume ratio of the powder is 1~2:1~2:1~2. A method for preparing plastic autologous bone paste, comprising the following steps: uniformly mixing Panax notoginseng saponin powder and human cryoprecipitate freeze-dried powder after Co60-γ-ray irradiation treatment, then adding calcium chloride solution, and mixing Evenly, and then mix the autologous bone powder evenly to obtain the moldable autologous bone paste. The shapeable autologous bone cement has the advantages of easy shaping, good shaping effect, easy fixation and good antibacterial effect, and can promote the healing of the operation area after mastoidectomy, so that the wound heals quickly and is very smooth.

Description

technical field [0001] The invention relates to the technical field of operation cavity packing composite materials, in particular to a shapeable autologous bone cement and a preparation method thereof. Background technique [0002] In clinical medicine, benign otological lesions such as chronic suppurative otitis media are surgical indications for radical mastoidectomy combined with tympanoplasty. However, due to the large operation cavity in the traditional operation, there are disadvantages such as unsatisfactory hearing recovery after operation, long recovery time after operation, low dry ear rate, and high recurrence rate. Therefore, the vast majority of otologists at home and abroad propose that mastoid cavity packing should be regarded as one of the important steps in radical mastoidectomy. [0003] Autologous bone powder is the most commonly used material for mastoid cavity filling in clinical practice. Autologous bone powder is considered by many scholars as the be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/54
Inventor 陈锡辉邹文婷
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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