A kind of synthetic method of quinazolinone aromatic compound

A quinazolinone aromatic and synthesis method technology, applied in the direction of organic chemistry, can solve the problems of harsh reaction conditions, narrow substrate range, and long reaction time, and achieve short reaction time, wide substrate range, and green post-treatment Effect
CN104496915BActive Publication Date: 2017-05-03HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2017-05-03

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Abstract

The invention discloses a synthetic method of a quinazolinone aromatic compound. The synthetic method comprises the following steps: dissolving 2-aryl indole, organic amine / inorganic amine and cuprous bromide in an organic solvent; carrying out reaction for 20-30 hours at 60-120 DEG C in the presence of oxygen; and separating and purifying to obtain the quinazolinone aromatic compound. According to the synthetic method, the raw materials are easily available and the yield is high (99%); the synthetic method is mild in reaction condition, short in reaction time, wide in primer range, strong in reaction specificity and simple and green in post-treatment.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a synthesis method of quinazolinone aromatic compounds. Background technique

[0002] Quinazolinone aromatic compounds are a class of widely used organic synthesis intermediates. It has important application value in daily commodities, pharmaceutical production, organic synthesis, and agricultural protection. Chemists have been trying in recent years. Some systems have been successfully applied to this reaction, and some research results have been obtained. However, there are many problems, such as: narrow substrate range, harsh reaction conditions, long reaction time, many by-products, low yield, and the need for non-green and environmentally friendly reagents such as strong acids, etc. Contents of the invention

[0003] The purpose of the present invention is to overcome the defects of the prior art and provide a synthetic method of quinazolinone arom...

Claims

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