Preparation method of dipeptide derivative Fmoc-FF self-assembly fiber by graphene oxide regulation

A technology of peptide derivatives and self-assembly, applied to the chemical characteristics of fibers, textiles and papermaking, etc., to achieve obvious effects, simple methods, and excellent mechanical properties

Inactive Publication Date: 2015-04-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, simply using Fmoc-oligopeptides for self-assembly still cannot meet people's needs for special materials. Therefore, it is necessary to use better materials to regulate the assembly of Fmoc-oligopeptides

Method used

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  • Preparation method of dipeptide derivative Fmoc-FF self-assembly fiber by graphene oxide regulation
  • Preparation method of dipeptide derivative Fmoc-FF self-assembly fiber by graphene oxide regulation
  • Preparation method of dipeptide derivative Fmoc-FF self-assembly fiber by graphene oxide regulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Prepare GO by Hummers method, the method is as follows:

[0055] A. Preoxidation

[0056] ①Weigh 12~18g K 2 S 2 o 8 and 12-18g P 2 o 5 Add to the 500ml round bottom flask successively,

[0057] ②Put the round-bottomed flask in an 80°C water bath,

[0058] ③ Measure 70-80ml of sulfuric acid into the round bottom flask,

[0059] ④Stir for 20-30min until the solution becomes clear,

[0060] ⑤ Add 20g graphene to the round bottom flask under protective measures,

[0061] ⑥Stir for 4.5 hours at 80°C,

[0062] ⑦Take out the round bottom flask, let it cool for a few minutes, then add the black mixture into a 2L Erlenmeyer flask,

[0063] ⑧ Add deionized water, make the volume constant to 2L, and collect the solid product with a vacuum filtration device,

[0064] ⑨The solid product is continuously rinsed with deionized water, and the pH value is checked until the pH value reaches about 5.

[0065] ⑩Let the product dry overnight.

[0066] B. Oxidation

[0067] ...

Embodiment 2

[0086] (1) prepare GO with Hummers method, with embodiment 1;

[0087] (2) Dissolve GO into deionized water with the help of an ultrasonic instrument, the ultrasonic time is 15min, the power frequency is 40KHz, and the large flakes of suspended GO are removed by centrifugation (3000rpm, 10min) to obtain a GO solution with a concentration of 0.03%;

[0088] (3) Prepare Fmoc-FF solution. Weigh Fmoc-FF and add it to HFIP, dissolve to obtain Fmoc-FF solution, wherein the ratio of Fmoc-FF to HFIP is 100mg: 1ml;

[0089] (4) Quickly add the GO solution to the Fmoc-FF solution dropwise, oscillate (the vortex oscillator shakes, the shaking time is 60s, and the rotation speed is 2000rpm / min), and mix well to obtain the Fmoc-FF / GO mixed system, wherein the Fmoc- The volume ratio of FF solution and GO is 30μl; 1ml;

[0090] (5) Immediately before the gelation of the mixed system, the above solution was drawn and dropped onto a clean silica glass plate, and then the samples were placed ...

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Abstract

The invention relates to a preparation method of a dipeptide derivative Fmoc-FF self-assembly fiber by graphene oxide regulation. The method includes the steps of: preparing GO; dissolving the GO in deionized water to obtain a GO solution; adding and dissolving a dipeptide derivative Fmoc-FF into HFIP to obtain a Fmoc-FF solution; rapidly dropwise adding the Fmoc-FF solution into the GO solution or adding the GO solution to the Fmoc-FF solution, oscillating and mixing to obtain a mixed system of Fmoc-FF and GO; and well mixing, immediately absorbing and dropwise adding the mixed solution onto a clean silica sheet, and drying respectively at room temperature and 60 DEG C. The method provided by the invention has simple, convenient for operation and obvious in effect; the preparation technology of the used GO is mature, has high yield, and realizes good biocompatibility; and the prepared Fmoc-FF / GO composite has wide potential application in biological materials and super capacitor.

Description

technical field [0001] The invention belongs to the field of dipeptide derivative Fmoc-FF, and particularly relates to a method for preparing a dipeptide derivative Fmoc-FF self-assembled fiber regulated by graphene oxide. Background technique [0002] Polypeptides are biologically active substances involved in various cellular functions in organisms. They are a type of compound between proteins and amino acids, and are formed by linking a variety of substances in a specific order and through peptide bonds. Peptide self-assembly refers to a class of molecular aggregates or supramolecular structures with clear structure, stable structure, and certain physical and chemical properties formed by the spontaneous combination of amino acid residues through non-covalent bond interactions under appropriate conditions. Since the polypeptide is composed of a variety of amino acids in a certain order through peptide bonds, and the amino acid residues on the chain segment have different ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F9/00
Inventor 朱利民公晓聂华丽
Owner DONGHUA UNIV
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