Thymalfasin inhalation powder and preparation method thereof

Abstract

The invention relates to the technical field of medicinal chemistry, in particular to thymalfasin inhalation powder and a preparation method thereof. The thymalfasin inhalation powder comprises thymalfasin superfine powder and pharmaceutically acceptable auxiliaries, wherein the average particle size of the thymalfasin superfine powder is 1-5 microns, and the maximum particle size of the thymalfasin superfine powder does not exceed 10 microns. According to the thymalfasin inhalation powder, the thymalfasin superfine powder can be well adsorbed onto the surfaces of carriers, and are inhaled through airflow to be desorbed from the surfaces of the carriers with larger particle sizes to enter the lung to achieve higher deposition rate during medication, and the carriers with larger particle sizes are intercepted at the throat to be prevented from being inhaled into the lung and causing adverse reaction; medicaments are directly delivered to the lung for action, so that toxic or side effects on the whole body of the medicaments are reduced, and the thymalfasin inhalation powder is convenient to use, lower in cost and higher in medicament stability.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a thymus method new inhalation powder and a preparation method thereof. Background technique [0002] Thymosin (thymosin α 1 ) is an acidic polypeptide chemically synthesized from twenty-eight amino acids. N-acetyl-L-seryl-L-α-aspartyl-L-alanyl-L-alanyl-L-valyl-L-α-aspartyl-L- Threonyl-L-seryl-L-seryl-L-α-glutamyl-L-isoleucyl-L-threonyl-L-lysyl-L-α-aspartate Acyl-L-leucyl-L-lysyl-L-lysyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L- α-glutamyl-L-alanyl-L-α-glutamyl-L-valyl-L-valyl-L-α-glutamyl-L-α-glutamyl-L- Alanyl-L-alpha-glutamyl-L-aspartyl. Molecular formula is C 129 h 215 N 33 o 55 , the molecular weight is 3108.28. [0003] Thymalfasin is a biological response modifier with a wide range of biological activities. It is clinically used to treat chronic hepatitis B, AIDS and malignant tumors, etc., with good curative effect; as a vaccine immune response e...

AI Technical Summary

Problems solved by technology

Although the relevant patents also disclose other dosage forms of Thymus method, such as sustained-release microsphere preparations, in-situ gel preparations and liposome preparations, these dosage forms have disadvantages such as complicated preparation process, poor stability, and poor bioavailability