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Fully bio-absorbable polymer stent and production method thereof

A vascular stent and polymer technology, applied in the field of fully bioabsorbable polymer vascular stents, can solve the problems of poor mechanical properties, slow degradation speed, high crystallinity, etc., and achieve small residual processing stress, fast degradation speed, and good toughness Effect

Inactive Publication Date: 2015-04-15
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a fully bioabsorbable polymer stent with strong toughness, low crystallinity and fast degradation rate for the defects of poor mechanical properties, high crystallinity and slow degradation rate in the existing fully bioabsorbable polymer stents. Polymer vascular stent and preparation method thereof

Method used

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  • Fully bio-absorbable polymer stent and production method thereof
  • Fully bio-absorbable polymer stent and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) The molar ratio of LLA / TMC / GA three monomers is 94.7 / 5.3 / 5.1, and the number average molecular weight is 1.53?10 5 g / mol, PLLA-TMC-GA terpolymer with a dispersion coefficient of 2.1, prepared by 3D printing as figure 1 For the fishbone-shaped vascular stent shown, the 3D printing molding layer thickness is 0.02mm, the molding accuracy is 0.02mm, the temperature of the printing head is 170°C, and the temperature of the 3D printing plate is 50°C.

[0032] (2) The radial support force of the vascular stent measured by a universal tensile testing machine is 1.8 bars.

[0033] (3) Put the scaffold in PBS buffer for a week, and observe that there are no obvious microcracks on the surface of the scaffold, indicating that there is no obvious processing residual stress.

[0034] (4) The bending strength of the bracket measured by the 3-point bending method is 93Kpa.

Embodiment 2

[0036] The number average molecular weight is 1.48?10 5 g / mol, the PLLA homopolymer with a dispersion coefficient of 1.7 was printed through the step (1) of Example 1 to obtain a fishbone-shaped vascular stent. The radial support force of the stent is 2.0bars. After soaking in PBS buffer solution for one week, a large number of cracks appear on the surface of the stent, and the bending strength measured by 3-point bending is 32Kpa.

[0037] By comparing the above two embodiments, it is found that the vascular stent of the present invention enhances the toughness of the vascular stent while maintaining a high strength, greatly improves the bending strength of the vascular stent, and the enhancement of toughness also makes the residual stress after processing also decreased significantly.

[0038] In order to better compare the difference in degradation performance between the vascular stent of the present invention and the PLLA-type vascular stent on the market, the following co...

Embodiment 3

[0040] The molar ratio of LLA / TMC / GA three monomers is 94.7 / 5.3 / 5.1, and the number average molecular weight is 1.53?10 5 g / mol, the PLLA-TMC-GA terpolymer with a dispersion coefficient of 2.1 was printed through the step (1) of Example 1 to prepare a fishbone-shaped vascular stent.

[0041] Put the scaffold into PBS buffer solution with pH=7.4 for in vitro degradation. After 6 months of degradation, the sample was taken out from the degradation solution, and then dried in a vacuum oven for one week to constant weight. The molecular weight after 6 months of degradation was measured by GPC to be 21% of the original molecular weight.

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Abstract

The invention belongs to the technical field of biomedical materials, in particular to a fully bio-absorbable polymer stent and a production method thereof. The stent provided by the invention is produced by forming high polymer materials through a processing technology. The high polymer materials are terpolymer prepared from high-molecular-weight polylactic acid, trimethylene carbonate and glycolide according to a certain matching ratio. The formation method includes laser engraving formation and 3D printing formation. The stent produced using the method provided by the invention has the radial support force of 0.8-1.9 bars and the bending strength of 80-220 KPa; within six-month degradation, the stent can maintain the mechanical support strength required by the blood vessel; therefore, the stent produced using the method provided by the invention has an excellent mechanical property, good biocompatibility and an ideal degradation rate, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a fully bioabsorbable polymer vascular stent. Background technique [0002] At present, the incidence of coronary heart disease is increasing day by day, and has become a major disease that threatens human life and health. The main treatment methods for coronary heart disease include drugs, surgery and interventional stents. Among them, the interventional vascular stent is a tubular support developed on the basis of balloon angioplasty for supporting blood vessels in diseased parts after recanalization. The use of interventional stents in the treatment of coronary heart disease has the advantages of small trauma, convenient and mature technology, fast and easy acceptance by patients, and has become an important method for the treatment of coronary heart disease. Since Sigwart first applied coronary stent implantation in clinical practice in 1987 (New En...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14
Inventor 范仲勇廖岚吴小蒙
Owner FUDAN UNIV
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