Glucose Sensing System

Abstract

The invention discloses a glucose sensing system. The glucose sensing system comprises a potentiostat, a first current-voltage converter, a second current-voltage converter, a differential amplifier and more than one group of sensor electrodes; the sensor electrodes are connected with the potentiostat; each group of sensor electrodes comprises two working electrodes; each first working electrode is electrically connected with the input end of the first current-voltage converter, the output end of each first current-voltage converter is electrically connected with one input end of the differential amplifier, each second working electrode is electrically connected with the input end of the second current-voltage converter, and the output end of the second current-voltage converter is electrically connected with the other input end of the different amplifier; the surface of each of the working electrodes is coated with a coating, and each coating is sequentially formed by an enzyme fixing layer, a control release layer and a biological compatible coating from inside to outside; besides the enzyme fixing layer, another coatings of the first working electrodes and the second working electrodes are correspondently identical; compared with the enzyme fixing layer of each second working electrode, glucose oxidase is additionally arranged in the enzyme fixing layer of each first working electrode.

Description

technical field [0001] The invention relates to a glucose sensing system, which belongs to the field of medical detection equipment. Background technique [0002] Diabetes is caused by genetic factors, immune dysfunction, microbial infection and other toxins, free radical toxins, mental factors and other pathogenic factors that act on the body to cause islet dysfunction, insulin resistance, etc. sugar, protein, fat, water, etc. and electrolytes and a series of metabolic disorders syndrome. Once the blood sugar of diabetics is not well controlled, it will lead to diabetic complications, such as hypoglycemia, ketoacidosis, coma, hypertension, heart disease, kidney failure, neuropathy, retinal damage, lower extremity gangrene, etc. [0003] Continuous blood glucose monitoring is to implant a glucose sensor under the skin of the patient to monitor the glucose concentration in the tissue fluid in real time. Diabetics can adjust their diet and work and rest according to the measu...

AI Technical Summary

Problems solved by technology

[0006] The commonly used way to prolong the life of sensors is to improve the biocompatibility of sensors. However, although biocompatible coatings can improve the biocompatibility of sensors and reduce the immune response and inflammatory response after implantation, they still cannot prevent The sensitivity and stability of the sensor will decline after long-term implantation; and, after the sensor is implanted in the body, it generally can only last for 3-5 days, and frequent replacement of the sensor will increase the economic burden of the patient sharply

In addition, the electrochemically active substances in the body undergo oxidation reactions on the electrode surface under the action of voltage, which affects the accuracy of the sensor.

Although anti-jamming coatings such as Nafion and cellulose acetate can reduce the influence of interfering substances on the sensor detection signal, long-term implantation in the body will still weaken the effect of the anti-jamming layer, and eventually the anti-jamming effect will not be achieved.

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