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Cimetidine composition freeze-drying tablet and preparation method thereof

A technology of cimetidine and composition, which is applied in the field of cimetidine composition freeze-dried tablet and its preparation, and achieves the effects of improving dissolution rate, improving adhesion and improving formability

Inactive Publication Date: 2015-04-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of cimetidine freeze-dried tablets by freeze-drying process

Method used

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  • Cimetidine composition freeze-drying tablet and preparation method thereof
  • Cimetidine composition freeze-drying tablet and preparation method thereof
  • Cimetidine composition freeze-drying tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026]

[0027] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-6.0, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.

[0028] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0029] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0030] D, take by weighing cimetidine 100g, add in 1L corn-sucrose solution, stir for 30 minutes.

[0031] E. After measuring the cimetidine content of the medicinal solution, divide th...

Embodiment 2

[0034]

[0035] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-6.0, then heat to 72°C and keep for 120 minutes to make 13% (W / V ) of cornstarch solution.

[0036] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0037] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0038] D, take by weighing 100 grams of cimetidine (calculated by 1000), add 1L corn-sucrose solution, stir for 30 minutes.

[0039] E. After measuring the cimetidine content of th...

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Abstract

The invention provides a cimetidine composition freeze-drying tablet and a preparation method thereof and relates to the technical field of medicines and medicine production. The cimetidine composition freeze-drying tablet comprises cimetidine, starch and cane sugar, wherein starch and cane sugar are used as auxiliary materials, and common corn starch is treated by virtue of a heating process, so that the bonding and disintegrating effects of starch in a tablet can be improved and the formability of the tablet is improved. The cimetidine composition freeze-drying tablet just needs two auxiliary materials, namely starch and cane sugar. According to the cimetidine composition freeze-drying tablet, a freeze-drying process of reducing the temperature twice and raising the temperature twice is adopted, so that the tablet formability is better and the dissolution rate of the tablet is improved, and therefore, the bioavailability of the tablet is improved. The tablet overcomes the defects of common cimetidine tablet, and the type and dosage of the auxiliary materials in the cimetidine tablet are reduced. The tablet is great in dissolution rate and high in bioavailability, and the curative effect and safety of clinical medication are guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a cimetidine composition freeze-dried tablet and a preparation method thereof. Background technique [0002] Cimetidine (cimetidine, cimetidine) is a selective H2 receptor antagonist listed in 1975 for the treatment of peptic ulcer. In recent years, the drug has been newly discovered for the treatment of non-ulcer diseases. [0003] [0004] Molecular weight: 252.34 [0005] Ordinary cimetidine tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. According to the second part of the Chinese Pharmacopoeia (2010 edition), Cimetidine quality standard, the dissolution rate of cimetidine tablets reaches more than 75% in 15 minutes is qualified, and more and more studies have shown that the toxic and side effects of the excipient itself, the incompatibility of the e...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K47/26A61K31/4164A61P1/04
Inventor 李青冬汪宁卿李珠珠饶经纬李彪
Owner HAINAN WEI KANG PHARMA QIANSHAN
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