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Acyclovir composition freeze-dried tablet and preparation method thereof

A technology of freeze-dried tablet and composition, applied in the field of acyclovir composition freeze-dried tablet and its preparation, to achieve the effects of improving adhesion, high bioavailability and improving bioavailability

Inactive Publication Date: 2015-04-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of acyclovir freeze-dried tablets by freeze-drying process

Method used

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  • Acyclovir composition freeze-dried tablet and preparation method thereof
  • Acyclovir composition freeze-dried tablet and preparation method thereof
  • Acyclovir composition freeze-dried tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.

[0029] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0030] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0031] D. Weigh 100 g of acyclovir, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.

[0032] E. After measuring the content of acyclovir in the medicinal solution,...

Embodiment 2

[0035]

[0036] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V ) of cornstarch solution.

[0037] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0038] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0039] D, take by weighing 100 grams of acyclovir (calculated as 1000 tablets), add 1L corn-sucrose solution, and stir for 30 minutes.

[0040] E. After measuring the content of...

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Abstract

The invention provides an acyclovir composition freeze-dried tablet and a preparation method thereof, and relates to the technical field of medicines and medicine production. The acyclovir composition freeze-dried tablet comprises acyclovir, starch and cane sugar, wherein the starch and the cane sugar are taken as auxiliary materials. Common corn starch is treated by a heating process, so that the bonding and disintegration functions of the starch in the tablet can be improved, and the formability of the tablet is improved. The acyclovir composition freeze-dried tablet only needs two auxiliary materials namely the starch and the cane sugar. The acyclovir composition freeze-dried tablet adopts the freeze-drying process that temperature is reduced and increased for two times respectively, and the process that temperature is reduced and increased for two times enables the formability of the tablet to be better and increases the dissolution rate of the tablet so as to improve the biological availability of the tablet; the tablet overcomes the defects of a common acyclovir tablet, the types and dosage of auxiliary materials in the acyclovir tablet are reduced, the dissolution rate of the tablet is high, the biological availability of the tablet is high, and the curative effect and the safety of clinical medication are ensured.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of acyclovir composition and a preparation method thereof. Background technique [0002] Aciclovir, also known as acyclovir, is a synthetic purine nucleoside analog antiviral drug. It is mainly used for various infections caused by herpes simplex virus, and can be used for initial or recurrent skin, mucous membrane, external genital infection and HSV infection in immunodeficiency patients; it is the first choice drug for the treatment of HSV encephalitis, which reduces the incidence and It is better than vidarabine in reducing mortality; it can also be used for herpes zoster, Epstein-Barr virus, and immunodeficiency complicated by chickenpox and other infections; it is only used locally on the skin, and the skin absorption of acyclovir is less. [0003] structural formula [0004] Molecular weight: 225.21 [0005] Ordinary acycl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/522A61K47/36A61K47/26A61P31/12A61P31/22
Inventor 聂晓丹李珠珠饶经纬李彪石金友
Owner HAINAN WEI KANG PHARMA QIANSHAN