Poly(lactic-co-glycolic acid) particles for dual imaging, as well as preparation method and application of poly(lactic-co-glycolic acid) particles
A glycolic acid and polylactic acid technology, applied in echo/ultrasonic imaging agents, medical preparations with inactive ingredients, pharmaceutical formulations, etc., can solve the problem of poor stability of liposomes, easy to be destroyed, and increase the surface of liposomes Tension and other problems, to achieve the effect of good biocompatibility, increased hydrophilicity, and high repeatability
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[0039] This embodiment provides a method for preparing double-imaging polylactic acid-glycolic acid copolymer particles, the preparation method comprising the following steps:
[0040] Dissolve 100mg of polylactic acid-glycolic acid copolymer in 5mL of organic solvent to prepare A solution with a concentration of 0.02g / mL;
[0041] Add 60 μL of liquid fluorocarbon to solution A, and mix well to obtain solution B;
[0042] Dissolve methylene blue in water to prepare C solution with a concentration of 1 mmol / L;
[0043] The surfactant is dissolved in water to prepare D solution with a mass concentration of 1.5%;
[0044] Add solution C to solution B, vortex and mix, and sonicate to obtain E emulsion, wherein the volume ratio of solution C to solution B is 1:2;
[0045] Drop E emulsion into D solution and stir magnetically to obtain F emulsion, wherein the volume ratio of E emulsion to D solution is 1:4;
[0046] The organic solvent in the F emulsion is completely volatilized by...
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