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Process for preparing tilmicosin pellets

A technology of tilmicosin and pellets, which is applied in the field of preparation of tilmicosin pellets, can solve the problems of incompleteness and inability to use laying hens

Active Publication Date: 2015-05-06
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When preventing and treating avian mycoplasma disease, more drugs are added to drinking water, but laying hens cannot use
Oral and subcutaneous injections of tilmicosin are rapidly absorbed, but not completely

Method used

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  • Process for preparing tilmicosin pellets
  • Process for preparing tilmicosin pellets
  • Process for preparing tilmicosin pellets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 The preparation method of tilmicosin pellets of the present invention

[0019] 1 Mix tilmicosin with an appropriate amount of microcrystalline cellulose (MCC) and low-substituted hypromellose (L-HPC) evenly, add an appropriate amount of diluted ethanol to moisten, pass through a 30-mesh sieve, and place the particles in a spheronizer Sphericalized and dried at 50°C, the skeleton-type sustained-release pellets I were obtained; the content of tilmicosin was 40%, and the ratio of MCC to L-HPC was 19:1. Among them, microcrystalline cellulose can also be sucrose or starch; low-substituted hypromellose (L-HPC) can also be hydroxypropyl cellulose (HPMC) or other skeleton materials, but this scheme is preferred.

[0020] 2 Dissolve an appropriate amount of povidone K90 (PVPK90) and carbomer in an appropriate amount of 80% ethanol solution, add tilmicosin and stir continuously to form a uniform suspension, add the ball core to the fluidized bed turntable, and The a...

Embodiment 2

[0022] Embodiment 2 The preparation method of tilmicosin pellets of the present invention

[0023] 1 Mix tilmicosin with an appropriate amount of microcrystalline cellulose (MCC) and low-substituted hypromellose (L-HPC) evenly, add an appropriate amount of diluted ethanol to moisten, pass through a 30-mesh sieve, and place the particles in a spheronizer Sphericalized and dried at 50°C, the skeleton-type sustained-release pellets I were obtained; the content of tilmicosin was 60%, and the ratio of MCC to L-HPC was 4:1. Among them, microcrystalline cellulose can also be sucrose or starch; low-substituted hypromellose (L-HPC) can also be hydroxypropyl cellulose (HPMC) or other skeleton materials, but this scheme is preferred.

[0024] 2 Dissolve an appropriate amount of povidone K90 (PVPK90) and carbomer in an appropriate amount of 80% ethanol solution, add tilmicosin and stir continuously to form a uniform suspension, add the ball core to the fluidized bed turntable, and The ab...

Embodiment 3

[0026] Embodiment 3 The preparation method of tilmicosin pellets of the present invention

[0027] 1 Mix tilmicosin with an appropriate amount of microcrystalline cellulose (MCC) and low-substituted hypromellose (L-HPC) evenly, add an appropriate amount of diluted ethanol to moisten, pass through a 30-mesh sieve, and place the particles in a spheronizer Sphericalized and dried at 50°C, the skeleton-type sustained-release pellets I were obtained; the content of tilmicosin was 50%, and the ratio of MCC to L-HPC was 10:1. Among them, microcrystalline cellulose can also be sucrose or starch; low-substituted hypromellose (L-HPC) can also be hydroxypropyl cellulose (HPMC) or other skeleton materials, but this scheme is preferred.

[0028] 2 Dissolve an appropriate amount of povidone K90 (PVPK90) and carbomer in an appropriate amount of 80% ethanol solution, add tilmicosin and stir continuously to form a uniform suspension, add the ball core to the fluidized bed turntable, and The a...

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Abstract

The invention provides a process for preparing tilmicosin pellets. The process comprises the following steps: a, uniformly mixing tilmicosin with a diluting agent and a disintegrating agent, adding ethanol, wetting, screening, rounding the particles in a rounding machine, and drying to obtain matrix type sustained-release pellets I; b, dissolving adhesive and carbomer in a 80% ethanol solution, adding tilmicosin into the ethanol solution to constantly stir to form a uniform suspension, adding the pellets I which are prepared in the step a and serve as pill cores into a fluidized bed turntable, spraying the suspension on the surfaces of the pill cores, drying, and collecting the dried pellets II; c, dissolving a coating agent in 80% ethanol, coating the pellets II, and drying to obtain the tilmicosin pellets. The tilmicosin pellets are stable and convenient to use, the bitter taste can be covered, and the pellets can be pressed into pellet tables for pets. The process is suitable for industrial production and popularization application.

Description

technical field [0001] The invention relates to a preparation process of tilmicosin pellets. Background technique [0002] With the rapid development of intensive farming, the spread of viral and bacterial diseases is very fast. Although we have vaccines as effective weapons to block the spread of viral diseases, many bacterial diseases that can cause animal death are still Rely on antibiotics. Due to the emergence of bacterial resistance, we urgently need to find new antibacterial drugs to fight against various drug-resistant bacteria, but the speed of successful development of antibacterial drugs is far lower than the needs of veterinary clinics, so how to fully and rationally apply existing antibacterial drugs Drugs are the guarantee for the sustainable and healthy development of the aquaculture industry. For a long time, the research of veterinary drug preparations has been simple and extensive. Many veterinary drug preparations have not fully considered the pharmacody...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/706A61K47/38A61P31/04
Inventor 唐华侨李超杨海涵余琴
Owner CHENGDU QIANKUN VETERINARY PHARMA
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