Traditional Chinese medicinal composition for treating infantile diarrhea as well as preparation method and application of traditional Chinese medicinal composition

A technology for infantile diarrhea and composition, which is applied in the field of traditional Chinese medicine composition for treating infantile diarrhea and its preparation, and can solve the problems of poor overall curative effect, slow effect, easy repetition, etc.

Inactive Publication Date: 2015-05-27
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, antibiotics and antiviral drugs are generally ineffective for children with spleen-deficiency diarrhea, and the abuse of antibiotics can easily cause flora imbalance; intestinal microecological preparations (Zhou Xiangang, Zhong Qu, Li Rui. Meta Analysis. Chinese Journal of Pediatrics, 2005, 43(6): 457-461), intestinal mucosa protective agents (Liu Hui, Huang Renfen, Zhang Yonghui. Analysis of 500 cases of children with diarrhea treated with Smecta. Chinese Community Physician, 2008, 3(10): 48) and zinc preparations (Cuevas LE, Koyanagi A. Zinc and infection: A review. Ann Trop Paediatr, 2005, 25(3): 149-160.) have improved the symptoms of spleen deficiency in children with diarrhea, but the course of treatment is longer , and it is easy to relapse because the cause cannot be eradicated, and the overall curative effect is not as ideal as traditional Chinese medicine treatment
Oral administration of traditional Chinese medicine has definite clinical curative effect in treating infantile diarrhea with spleen deficiency and is still used today. However, ancient and modern literature records mostly use the method of invigorating the spleen, replenishing qi, dispelling dampness and stopping diarrhea, such as Qiweibaizhu powder, Shenlingbaizhu powder, etc. The effect is slow and the course of treatment is long. Long, reported such as Yunpi Zhixie Decoction (Yang Yan, Yan Huimin, Wang Sumei, Hong Lijun, Wang Mengqing, Fan Hua. Multicenter clinical effectiveness analysis of Yunpi Zhixie Decoction in treating children with spleen deficiency diarrhea. Pediatrics of Traditional Chinese and Western Medicine, 2011, 3 (1): 7-8), Yunpi Guchang Decoction (Zhang Nan. Observation on the clinical efficacy of Yunpi Guchang Decoction in the treatment of children with diarrhea due to spleen deficiency. Hunan University of Traditional Chinese Medicine), etc. Diarrhea is the main method of treatment, and has not yet been developed into a medicine for clinical application

Method used

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  • Traditional Chinese medicinal composition for treating infantile diarrhea as well as preparation method and application of traditional Chinese medicinal composition
  • Traditional Chinese medicinal composition for treating infantile diarrhea as well as preparation method and application of traditional Chinese medicinal composition
  • Traditional Chinese medicinal composition for treating infantile diarrhea as well as preparation method and application of traditional Chinese medicinal composition

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Experimental program
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Effect test

Embodiment 1

[0099] Embodiment 1: the preparation method of the granule of medicine of the present invention, its steps are as follows: take by weighing 150 parts of Atractylodes Rhizoma Atractylodis, 150 parts of Poria cocos, 60 parts of Pao Jiang, 150 parts of stewed Yi Zhi Ren, 300 parts of raw malt, and 30 parts of Amomum.

[0100] 1) Take Pao Jiang, add 75% ethanol aqueous solution to reflux and extract for 3 times, each time for 2 hours, collect the extract, filter, combine the filtrate, concentrate to 70 ° C when the relative density is 1.25 extract, dry to obtain Extract I, collect medicinal residues at the same time, dry for later use;

[0101] 2) Take Atractylodes atractylodis, mix Yizhiren and Amomum, add water 10 times the weight of the medicinal material to reflux for extraction for 3 hours, collect the volatile oil, concentrate the filtrate to an extract with a relative density of 1.20 at 70°C, dry to obtain the extract II, and dry the dregs Dried for use, the volatile oil is...

Embodiment 2

[0104] Embodiment 2: the preparation method of oral liquid or syrup of medicine of the present invention, its steps are as follows:

[0105] According to the weight of the following unilateral medicinal taste, take a certain multiple of raw materials (Chinese herbal pieces after processing): weigh 150 parts of Atractylodes atractylodes Rhizome, 150 parts of Poria cocos, 60 parts of Pao Jiang, 150 parts of stewed Yizhiren, 300 parts of raw malt, Amomum 30 parts.

[0106] 1) Take Pao Jiang, add 75% ethanol aqueous solution to reflux and extract for 3 times, each time for 2 hours, collect the extract, filter, combine the filtrate, and concentrate to an extract with a relative density of 1.25 at 70°C to obtain the extract 1, collect medicinal residues simultaneously, dry stand-by;

[0107] 2) Take Atractylodes atractylodis, mix Yizhiren and Amomum, add water 10 times the weight of the medicinal materials to reflux for extraction for 3 hours, collect the volatile oil, concentrate ...

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating infantile diarrhea. The traditional Chinese medicinal composition for treating the infantile diarrhea are prepared by extracting the following traditional Chinese medicine active ingredients in parts by weight: 50-250 parts of rhizoma atractylodis, 50-250 parts of poria cocos, 25-120 parts of baked ginger, 50-250 parts of fructus alpiniae oxyphyllae, 100-500 parts of roasted malt and 10-60 parts of fructus amomi. The invention also discloses a preparation method and application of the traditional Chinese medicinal composition for treating the infantile diarrhea. The traditional Chinese medicinal composition for treating the infantile diarrhea has the effects of treating the infantile diarrhea, protecting an intestinal mucosal barrier and regulating intestinal flora, and experimental study shows that the traditional Chinese medicinal composition for treating the infantile diarrhea has an obvious curative effect when being used for treating intestinal mucosal injury caused by the infantile diarrhea and chronic splenasthenic diarrhea and alteration of intestinal flora and is an ideal medicine for treating the intestinal mucosal injury caused by the infantile diarrhea and chronic splenasthenic diarrhea and alteration of intestinal flora.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating infantile diarrhea, a preparation method and application thereof. Background technique [0002] Diarrhea in children is a group of digestive system diseases caused by multiple pathogens and factors, and it is a worldwide public health problem. The Chinese government has also listed it as one of the four major diseases of pediatrics. According to the statistics of the World Health Organization (WHO), 1 billion people in the world suffer from diarrheal diseases every year, 500 million of which occur in developing countries, resulting in 5 million child deaths. In my country, infantile diarrhea is the second most common and frequently-occurring disease in pediatrics (after respiratory tract infection). Traditional Chinese medicine believes that the key to the pathogenesis of diarrhea is spleen deficien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/12A61P1/00
Inventor 汪受传康安单进军徐珊狄留庆
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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