Preparation technology of oral placental peptide chitosan-sodium alginate sustained-release microcapsules

Abstract

Using W / O / W emulsified gel-external cross-linking method to prepare polypeptide sustained-release microcapsules. The experimental research found that the process of microcapsules has good formability, mainly in round, oval and diamond shapes, with an average particle size of 125um, an average drug encapsulation rate of 76.60%, and a drug loading capacity of 6.3mg / g; in vitro The model intestinal fluid drug release test showed that the cumulative drug release rate was 65.60% in the first 8 hours, and slowly released after 8 hours, and the cumulative drug release rate reached 90.46% in 24 hours, which has good sustained release performance and meets the requirements of oral pharmacokinetics. Chitosan and sodium alginate can be used as carrier materials for the biodegradation of polypeptide drugs, which can better improve the stability of the molecular structure and efficacy of placental peptides. The W / O / W emulsion gel-external cross-linking method is simple and easy to operate The prepared microcapsules have high encapsulation efficiency and drug loading capacity, good sustained release performance, and particle size and drug release degree meet the requirements of oral pharmacokinetics. The microcapsules are expected to become the carrier of oral polypeptide drugs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation process for oral placenta peptide chitosan-sodium alginate slow-release microcapsules. Background technique [0002] In recent years, studies have found that placental peptides have a high immune and physiological regulatory effect on the body [1-10] , It has a good effect on the adjuvant treatment of viral infectious diseases, fungal infections, immunodeficiency and other diseases [11] ; Due to the unstable molecular structure and short half-life of the polypeptide, it is easily degraded by a large number of proteolytic enzymes in the gastrointestinal tract during oral administration and loses its activity, which limits the administration of this type of drug. With the continuous development of biotechnology, more and more peptide drugs have been discovered, and the oral administration of peptide drugs has become a focus in the field of medicine. Contents of the inventio...

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Problems solved by technology

[0002] In recent years, studies have found that placental peptides have a high immune and physiological regulation effect on the body [1-10] , It has a good effect on the adjuvant treatment of viral infectious diseases, fungal infections, immunodeficiency and other diseases [11] ; Due to the unstable molecular structure and short half-life of the polypeptide, it is easily degraded by a large number of proteolytic enzymes in the gastrointestinal tract during oral administration and loses its activity, which limits the administration of this type of drug