Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for removing ginkgolic acid in ginkgol biloba extract

A technology of ginkgo extract and ginkgolic acid, which is applied in the field of removing gingkgolic acid, can solve the problems of high input cost, large amount of solvent, and high technical difficulty, and achieve low manufacturing and maintenance costs, low operating costs, and low technical difficulty. Effect

Active Publication Date: 2015-07-01
ZHEJIANG UNIV OF TECH
View PDF5 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Sensitization: Excessive intake of ginkgolic acid may lead to allergic reactions, nerve damage and gene mutations. The sensitization mechanism may be inhibition of enzyme activity, cytotoxicity, allergic reactions, etc.
[0005] 2. Ginkgolic acid has the effect of inhibiting the activity of gene recombination, and will inhibit the catalytic activity of CYP enzymes
[0006] 3. Embryotoxicity, nephrotoxicity, carcinogenesis, etc.
[0008] The disadvantages of the above method mainly include: the use of CO 2 The separation technology required for supercritical extraction is demanding, the cost of reaching low temperature is high, and the input cost is high; during organic solvent extraction, the amount of solvent used is large and it is easy to cause environmental pollution; the selectivity of resin adsorption is poor, and the operation process is technically difficult , and the regeneration of the resin is difficult

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weighing of raw materials: Weigh 25 g of commercially available Ginkgo biloba extract.

[0035] (2) Suspension preparation: Add 700ml of water into a beaker filled with commercially available Ginkgo biloba extract, stir well to make the extract dissolve as much as possible.

[0036] (3) Add saturated NaHCO 3 solution, adjust the pH to 8.

[0037] (4) Surfactant dosage: Weigh 0.75 g of surfactant, which is a mixture of Span-20 and Tween-20, and the mass ratio of the two is 1:2.

[0038] (5) Add a surfactant to the above suspension, mix and transfer to a foam separator.

[0039] (6) After the above work is completed, air is introduced from the bottom of the foam separator at room temperature. Control the gas velocity of the air at about 80ml / min.

[0040] (7) Collect the foam taken out from the upper end of the foam separator, and the foam is the solution containing ginkgolic acid. The solution treated in the foam separator is the solution for removing ginkgolic ac...

Embodiment 2

[0042] (1) Weighing of raw materials: Weigh 30 g of commercially available Ginkgo biloba extract.

[0043] (2) Suspension preparation: Add 800ml of water into a beaker filled with commercially available ginkgo extract to dissolve the extract as much as possible.

[0044] (3) Add saturated NaHCO 3 solution, adjust the pH to 7.5.

[0045] (4) Surfactant dosage: Weigh 0.88g of surfactant, the mass ratio of the surfactant Span-20 and Tween-20 is 1:2.

[0046] (5) Add the weighed surfactant to the above suspension, mix and transfer to the foam separator.

[0047] (6) After the above work is completed, air is introduced from the bottom of the foam separator at room temperature. Control the gas velocity of the air at 90ml / min.

[0048] (7) Collect the foam taken out from the upper end of the foam separator, and the foam is the solution containing ginkgolic acid. The solution treated in the foam separator is the solution for removing ginkgolic acid, using high performance liquid ...

Embodiment 3

[0050] (1) Weighing of raw materials: Weigh 40 g of commercially available Ginkgo biloba extract.

[0051] (2) Suspension preparation: Add 900ml of water into a beaker filled with commercially available ginkgo extract to dissolve the extract as much as possible.

[0052] (3) Add saturated NaHCO 3 solution, adjust the pH to 8.5.

[0053] (4) Surfactant dosage: Weigh 1.10 g of surfactants, the surfactants are Span-20 and Tween-80, and the mass ratio of the two is 1:2.

[0054] (5) Add the weighed surfactant to the above suspension, mix and transfer to the foam separator.

[0055] (6) After the above work is completed, air is introduced from the bottom of the foam separator at room temperature. Control the gas velocity of the air at 100ml / min.

[0056] (7) Collect the foam taken out from the upper end of the foam separator, and the foam is the solution containing ginkgolic acid. The solution treated in the foam separator is the solution for removing ginkgolic acid, using hig...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for removing ginkgolic acid in a ginkgo biloba extract. The method comprises the following steps: firstly detecting the content of ginkgolic acid in the ginkgo biloba extract; then adding water into the ginkgo biloba extract; fully stirring and dissolving; adding a non-toxic alkaline substance to adjust the pH to 7-10; then adding a surfactant; after uniformly mixing, adding the obtained raw material liquid into a foam separator; continuously blowing air from the bottom of the foam separator to form foam; collecting foam discharged from the top end of the foam separator till no foam is generated, wherein the obtained foam liquid is a solution containing the ginkgolic acid and the residual foam-free solution in the foam separator is a solution without the ginkgolic acid; and concentrating and drying the solution without the ginkgolic acid to obtain the ginkgo biloba extract without the ginkgolic acid, wherein the surfactant is a polyhydric alcohol surfactant. The method disclosed by the invention is simple to operate, high in ginkgolic acid removal rate and low in operating cost, and the content of th ginkgolic acid in the ginkgo biloba extract finally obtained is reduced to below 5ppm.

Description

(1) Technical field [0001] The invention relates to a method for removing ginkgolic acid from ginkgo extract. (2) Background technology [0002] Ginkgo tea is a kind of health product refined from ginkgo leaves. There are hundreds of kinds of ginkgo tea on the market. Its main medicinal ingredients, flavonoids and lactones, can improve cardiovascular and cerebrovascular circulation and antagonize platelet activating factor. And antithrombotic effects, can be used to prevent and treat diseases such as senile dementia and cerebral thrombosis. However, ginkgo contains ginkgolic acid, which is the main toxic substance in ginkgo leaf extract and ginkgo tea, and its food safety has attracted people's attention. [0003] Ginkgolic acid substances are derivatives of a class of salicylic acid substances. The length of the carbon chain connected at the 6-position of the benzene ring can be 13 to 17 carbon atoms, and the number of double bonds in the carbon chain can be 0 to 3. Theref...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/16A23L1/30A23L1/015A23L5/20
Inventor 李良英金志敏聂敏
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com