Application of aloin in preparation of medicine for treating ischemic stroke

A technology for ischemic stroke and ischemic stroke, which is applied in the field of use of aloin in the preparation of medicines for the treatment of ischemic stroke, can solve the problem that the protective effect has not yet been reported, and can reduce the apoptosis rate, increase the Content, the effect of ischemic injury protection

Active Publication Date: 2017-09-12
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that aloin can help expel dirt from the body, purify blood, soften blood vessels, reduce blood pressure and blood viscosity, promote blood circulation, and prevent arteriosclerosis and cerebral hemorrhage. The protective effect of injury disease has not been reported so far, and its development as a drug for the treatment of ischemic stroke has extremely high potential value and social significance

Method used

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  • Application of aloin in preparation of medicine for treating ischemic stroke
  • Application of aloin in preparation of medicine for treating ischemic stroke
  • Application of aloin in preparation of medicine for treating ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The use of aloin in the preparation of medicines for treating ischemic stroke, wherein the molecular structural formula of aloin is shown in formula (1)

[0022]

[0023] Ischemic stroke refers to ischemic stroke in the acute stage or repair stage. The single application dose of aloin in the cells is 10 μg / mL, and the dosage form of the drug is a powder injection dosage form allowed by pharmacy.

Embodiment 2

[0025] The use of aloin in the preparation of medicines for the treatment of ischemic stroke, wherein the molecular structural formula of aloin is shown in formula (1)

[0026]

[0027] Ischemic stroke refers to ischemic stroke in the acute stage or repair stage, the single application dose of aloin in the cells is 20 μg / mL, and the dosage form of the drug is an injection dosage form allowed by pharmacy.

Embodiment 3

[0029] The use of aloin in the preparation of medicines for the treatment of ischemic stroke, its molecular structural formula is shown in formula (1)

[0030]

[0031] The ischemic stroke is ischemic stroke in the acute phase or repairing phase, the single application dose of aloin in the cells is 40 μg / mL, and the dosage form of the drug is an oral dosage form permitted by pharmacy.

[0032] The effect of embodiment 1-3 can be verified by following animal experiments:

[0033] 1. Experimental materials

[0034] Cultured PC-12 cells, methazolium blue (MTT) was purchased from Guangzhou Chemical Reagent Factory; microplate reader was purchased from Thermo Company; lactate dehydrogenase LDH, malondialdehyde MDA, superoxide dismutase SOD, ROS assay Reagent kit: product of Nanjing Jiancheng Institute of Bioengineering; calcium ion, Hoechst, MMP kit: Biyuntian Reagent Company; Annexin V-FITC cell apoptosis detection kit: Shanghai Beibo Biological Company. Caspase-3, Bcl-2, Bax...

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Abstract

The invention discloses the application of aloin (Aloin) as a medicine for treating ischemic stroke, and explores the protective effect and possible mechanism of aloin on PC-12 cells after oxygen-glucose deprivation by establishing an oxygen-glucose deprivation model. The experimental results show that after oxygen-glucose deprivation reperfusion, the protective effect of aloin is related to anti-oxidation, it reduces the content of active oxygen and malondialdehyde in cells, and increases the content of superoxide dismutase; in addition, Aloe vera can stabilize the mitochondrial membrane potential, reduce the apoptosis rate and calcium ion concentration of PC‑12 cells, indicating that these results prove that aloin has a protective effect on ischemic injury.

Description

technical field [0001] The invention relates to the application of aloin, in particular to the application of aloin in the preparation of medicine for treating ischemic stroke. Background technique [0002] Ischemic Brain Disease (Ischemic Brain Disease), also known as ischemic stroke, has become one of the major fatal and disabling diseases worldwide, seriously threatening human life and health. Studies have found that after cerebral ischemia, a considerable part of the blood vessels can be recanalized naturally or after thrombolytic therapy, but it will lead to brain damage and dysfunction, that is, ischemia reperfusion injury (Ischemia Reperfusion Injury), thus inhibiting ischemia. Reperfusion injury has become a key link in the treatment of ischemic encephalopathy. [0003] Research on the mechanism of cerebral ischemia-reperfusion injury has progressed rapidly in recent years. Studies have found that brain cell damage caused by interruption of cerebral blood flow and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/351A61P9/10
Inventor 周茹常人元余建强郑婕赵启鹏张万年
Owner NINGXIA MEDICAL UNIV
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