Single-point double-parameter fluorescence optical fiber sensor probe for monitoring pH value and oxygen partial pressure

Abstract

The invention provides a single-point double-parameter fluorescence optical fiber sensor probe for monitoring a pH value and oxygen partial pressure. The probe comprises an optical fiber probe, a polyurethane hydrogel layer fixed on the optical fiber probe, and pH-sensitive particles and oxygen-sensitive particles dispersed and embedded into the polyurethane hydrogel layer, and is characterized in that the pH-sensitive particles are prepared by covalently fixing HPTS on the amido modified p-HEMA; and the oxygen-sensitive particles are prepared by embedding Ru(dpp)32+ on organically modified silicate by virtue of solvent trichloromethane. According to the probe disclosed by the invention, the problems that cross interference is caused by resonance energy transfer among multiple indicators, photolysis and signal drift of the indicators can be caused by co-existence of the multiple indicators and the like in the traditional sensor can be solved.

Description

technical field [0001] The invention relates to a single-point dual-parameter fluorescent optical fiber sensor probe for monitoring pH value and oxygen partial pressure. Background technique [0002] In medical clinical diagnosis, blood oxygen partial pressure (pO 2 ) and pH (pH value) are two important detection indicators for evaluating the pathophysiological state of a patient. In the monitoring of critically ill patients such as shock, respiratory failure, and brain injury and major anesthesia operations, it is necessary to frequently measure the pO of blood or tissue 2 and pH value to evaluate the patient's oxygen supply and demand balance and acid-base balance. [0003] At present, conventional blood gas analyzers are often used clinically, through intermittent arterial blood collection, and chemical analysis of blood samples in vitro to obtain pO 2 And multi-parameter information such as pH value. Routine blood gas analysis has several disadvantages: intermittent ...

AI Technical Summary

Problems solved by technology

[0007] The invention provides a single-point dual-parameter fluorescent optical fiber sensor probe for monitoring pH value and oxygen partial pressure, which can solve the problem of cross-interference caused by resonance energy transfer between multiple indicators in traditional sensors, and the coexistence of multiple indicators that will cause the indicator light problems such as solution and signal drift

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