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Medicine for treating renal fibrosis

A technology of traditional Chinese medicine and ginseng leaves, which is applied in the field of drugs for the treatment of renal fibrosis, and can solve problems such as unsatisfactory curative effects

Inactive Publication Date: 2015-07-22
THE THIRD PEOPLES HOSPITAL OF QINGDAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Western medicine clinical treatment of renal fibrosis mainly focuses on controlling the factors that cause the deterioration of renal function (such as hypertension, high protein intake, hyperuricemia, etc.). 1 Anti-fibrosis, such as antibodies, hormones, interferon, ACEI, etc., but the efficacy is not satisfactory, and most of them are still in the experimental stage or only used in animal models of renal fibrosis

Method used

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  • Medicine for treating renal fibrosis
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preparation example Construction

[0052] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine, when the prepared dosage form is an oral liquid, comprising:

[0053] In the first step, the salvia miltiorrhiza, ginseng leaves, sharp tail wind, peach kernels, Eclipta chinensis, Ophiopogon japonicus, Cistanche, chrysanthemum chrysanthemum, goosegrass, chrysanthemum seed and lice grass are respectively crushed into powders and mixed together to obtain a mixture , add 10 times the amount of water relative to the mass of the mixture, shake and mix, soak for 30 to 40 minutes, connect the reflux condenser, heat to boiling, and keep boiling at 100°C for 2 hours, stop heating, cool to room temperature, and dissolve the medicinal liquid Filter and pour it out to get the first filtrate, then add water with 8 times the mass of the mixture to the filter residue, shake and mix, soak for 30 minutes, connect the reflux condenser, heat to 100°C to boil, and keep it for 1 hou...

Embodiment 1

[0065] Example 1 Oral Liquid 1

[0066] Grind 36g of Salvia miltiorrhiza, 55g of ginseng leaves, 25g of Jianweifeng, 18g of peach kernels, 38g of Eclipta chinensis, 34g of Liedong, 31g of Cistanche, 22g of white chrysanthemum, 24g of goosegrass, 25g of mulberry seed and 20g of lice flower into powder respectively , mixed together to obtain a mixture, add 3.3kg of water, shake and mix, soak for 30min, connect the reflux condenser, heat to boiling, and keep boiling at 100°C for 2 hours, stop heating, cool to room temperature, and the Chinese herbal medicine The liquid was filtered and poured out to obtain the first filtrate, and 2.6kg of water was added to the filter residue, shaken and mixed, soaked for 30min, connected to a reflux condenser, heated to 100°C to boil, and kept for 1 hour, stopped heating, cooled to room temperature, and Wherein the medicinal liquid is filtered and poured out to obtain the second filtrate, the first filtrate and the second filtrate are mixed, con...

Embodiment 2

[0067] Embodiment 2 oral liquid 2

[0068] Grind 34g of salvia miltiorrhiza, 53g of ginseng leaves, 23g of Jianweifeng, 16g of peach kernels, 36g of Eclipta chinensis, 32g of Lithops japonicus, 29g of Cistanche, 20g of white chrysanthemum, 22g of goosegrass, 23g of mulberry seeds and 18g of lice flowers into powder respectively , mixed together to obtain a mixture, add 3.1kg of water, shake and mix, soak for 30min, connect the reflux condenser, heat to boiling, and keep boiling at 100°C for 2 hours, stop heating, cool to room temperature, and dissolve the The liquid was filtered and poured out to obtain the first filtrate, and 2.6kg of water was added to the filter residue, shaken and mixed, soaked for 30min, connected to a reflux condenser, heated to 100°C to boil, and kept for 1 hour, stopped heating, cooled to room temperature, and Wherein the medicinal liquid is filtered and poured out to obtain the second filtrate, the first filtrate and the second filtrate are mixed, con...

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Abstract

The invention provides a traditional Chinese medicine for treating renal fibrosis. The traditional Chinese medicine comprises the following raw material medicines: salvia miltiorrhiza, ginseng leaves, saffron, myrrh, callicarpa longissima, Gordon Euryale seed, lotus seed, peach seed, yerbadetajo herb, liriope spicata, cistanche deserticola, rabdosia rubescens, aster ageratoides, polygonum cuspidatum, eleusine indica, paper mulberry fruit and dominant pulicaria flower. Compared with purer western medicine treatment, treatment with the traditional Chinese medicine has the advantages that renal fibrosis indexes can be better reduced, clinical signs of a patient can be improved, and renal diseases can be prevented from getting worse.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating renal fibrosis. Background technique [0002] Renal fibrosis refers to the excessive deposition of extracellular matrix in the kidney caused by various reasons. It refers to the pathological repair response of the kidney under the action of various pathogenic factors such as inflammation and injury, and its essence is the proliferation of fibroblasts, excessive accumulation of extracellular matrix (ECM) and progressive decline of renal function. [0003] Renal fibrosis is the manifestation of almost all renal diseases progressing to end-stage renal failure, and it is also one of the main pathological manifestations of the chronicity of various renal diseases. [0004] Western medicine clinical treatment of renal fibrosis mainly focuses on controlling the factors that cause the deterioration of renal function (such as hypertension, hig...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P13/12
Inventor 刘泽涛于莉程绍云范爱秀
Owner THE THIRD PEOPLES HOSPITAL OF QINGDAO
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