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Aerosol precursor containing effective components in anti-inflammatory drug and method for dispersing effective components in anti-inflammatory drug into nanoscale droplets

A technology for medicinal components and anti-inflammatory drugs, applied in the field of aerosol precursors, can solve the problems of high cost of propellants, reduced pressure in the tank, and poor drug atomization effect, so as to improve the effective utilization rate and overcome losses. , the effect of shortening the action time

Inactive Publication Date: 2015-07-29
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The representative patent for pressurized atomization of traditional Chinese medicine compound preparations is CN102949573A, in which an 80-100bar propellant such as trichlorofluoromethane, dichlorodifluoromethane or dichlorotetrafluoroethane is used to atomize the liquid medicine to To obtain micron-sized mist droplets, the above-mentioned injection pressure is too high, the airtightness of the propellant container tank is strict, the production cost is high, and the propellant itself is also expensive
In addition, with the increase of the amount of medicine used, the pressure inside the tank decreases continuously, and the drug atomization effect gradually becomes worse; moreover, such tanks can only be used once for consumers, increasing usage cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] An aerosol precursor containing the active ingredients of anti-inflammatory drugs, which includes glycerol, propylene glycol, 1,3-butanediol, flavoring substances and anti-inflammatory drug extracts, and their mass ratio is glycerol: propylene glycol: Anti-inflammatory drug extract = 40:20:1.

[0039] Wherein said anti-inflammatory drug extract is obtained by the method comprising the following steps:

[0040] (1) Impurity removal: dissolving the anti-inflammatory and antipyretic granules in food-grade ethanol, filtering, removing insoluble impurities, and obtaining an ethanol solution of anti-inflammatory and antipyretic granules;

[0041] (2) Decolorization: the ethanol solution of the anti-inflammatory and antipyretic granules obtained in step (1) is passed through a macroporous resin chromatographic column, and is eluted with an ethanol-water solution with a concentration of 50% by volume to remove the pigment components therein; and use molecular distillation The ...

Embodiment 2

[0045] An aerosol precursor containing the active ingredients of anti-inflammatory drugs, which includes glycerol, propylene glycol, 1,3-butanediol, flavoring substances and anti-inflammatory drug extracts, and their mass ratio is glycerol: propylene glycol: Anti-inflammatory drug extract = 40:20:1.

[0046] Wherein said anti-inflammatory drug extract is obtained by the method comprising the following steps:

[0047] (1) Impurity removal: Grinding Xiaoyan Lidan Tablets into powder and dissolving them in food-grade ethanol, filtering to remove insoluble impurities to obtain the ethanol solution of Xiaoyan Lidan Tablets;

[0048] (2) decolouring: the ethanol solution of Xiaoyan Lidan Tablets obtained in step (1) is passed through the first macroporous resin chromatographic column, and is 50 volume % ethanol-water solution eluting with concentration, removes the pigment component wherein; And utilize Solvent is removed by molecular distillation to obtain the first extract; where...

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Abstract

The invention relates to an aerosol precursor containing effective components in an anti-inflammatory drug. The aerosol precursor comprises glycerin, propylene glycol, 1,3-butanediol, flavor components and an anti-inflammatory drug extract in the mass ratio being (40-45): (20-25): (0-10): (0-10): (1-10). The invention further relates to a method for dispersing the effective components in the anti-inflammatory drug into nanoscale droplets, and relates to an aerosol containing the nanoscale droplets. The aerosol precursor contains the effective components in the anti-inflammatory drug, and the nanoscale droplets can be obtained when the aerosol precursor is placed and heated in an electronic cigarette smoking set comprising an electric heater.

Description

technical field [0001] The invention relates to an aerosol precursor, in particular to an aerosol precursor containing an anti-inflammatory drug and a method for dispersing it into nano-scale droplets. Background technique [0002] Inflammation is what people usually call "inflammation". It is a basic pathological process that occurs when biological tissues are stimulated by certain stimuli, such as trauma, infection and other damage factors. The local manifestations of inflammation are redness, swelling, heat, pain and dysfunction, and also accompanied by systemic reactions such as fever and changes in peripheral white blood cell count. Among the Chinese patent medicines, Chinese patent medicines containing forsythia, honeysuckle, Radix Isatidis, Folium Isatidis, Scutellaria baicalensis, Dandelion, Houttuynia cordata and other ingredients are selected, all of which have anti-inflammatory effects; and, compared with western medicines, the side effects of Chinese patent medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K45/00A61K47/10A61P29/00A61K36/708A61K36/736A61K36/86A61K35/65A61K35/618A61K35/413A61K33/36A61K35/62A61K35/32A61K33/06
Inventor 陈永宽赵伟杨柳尚善斋田永峰张霞韩熠韩敬美袁大林雷萍段沅杏杨继汤建国郑绪东缪明明
Owner CHINA TOBACCO YUNNAN IND
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