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Tertiary calcium phosphate/zirconia bioceramic and preparation method thereof

A technology of tricalcium phosphate and bioceramics, used in tissue regeneration, prosthesis, medical science, etc., can solve the problems of inability to withstand force impact, low mechanical strength of β-TCP ceramics, and achieve good compressive strength and fracture toughness. , Improve mechanical properties, good biocompatibility

Active Publication Date: 2015-07-29
江苏瀚仁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The disadvantage of β-TCP ceramics is that the mechanical strength is low and cannot withstand the impact of force

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A tricalcium phosphate / zirconia bioceramic, comprising the following components in parts by mass:

[0026] 40 parts of tricalcium phosphate, 20 parts of zirconia, 5 parts of calcium silicate, 3 parts of nano-titanium oxide, 3 parts of medical stone powder, 4 parts of potassium metaphosphate and 2 parts of nano-tungsten oxide.

[0027] Prepare tricalcium phosphate / zirconia bioceramics according to the preparation method provided by the invention, the steps are as follows:

[0028] (1) Weighing: Accurately weigh each component;

[0029] (2) Ball milling: Mix the components together and put them into a ball mill for grinding and mixing;

[0030] (3) Cold press forming: the mixed powder is pressed with a 60T press;

[0031] (4) Put the formed powder into the mold and perform high-temperature calcination at a temperature of 1300°C and a pressure of 400MPa for 4 hours;

[0032] (5) After calcination, take it out after cooling to obtain block tricalcium phosphate / zirconia b...

Embodiment 2

[0035] A tricalcium phosphate / zirconia bioceramic, comprising the following components in parts by mass:

[0036] 60 parts of tricalcium phosphate, 40 parts of zirconia, 15 parts of calcium silicate, 6 parts of nano-titanium oxide, 6 parts of medical stone powder, 9 parts of potassium metaphosphate and 5 parts of nano-tungsten oxide.

[0037] Prepare tricalcium phosphate / zirconia bioceramics according to the preparation method provided by the invention, the steps are as follows:

[0038] (1) Weighing: Accurately weigh each component;

[0039] (2) Ball milling: Mix the components together and put them into a ball mill for grinding and mixing;

[0040] (3) Cold press forming: the mixed powder is pressed with a 60T press;

[0041] (4) Put the formed powder into the mold and perform high-temperature calcination at a temperature of 1300°C and a pressure of 400MPa for 7 hours;

[0042] (5) After calcination, take it out after cooling to obtain block tricalcium phosphate / zirconia ...

Embodiment 3

[0045] A tricalcium phosphate / zirconia bioceramic, comprising the following components in parts by mass:

[0046] 45 parts of tricalcium phosphate, 25 parts of zirconia, 9 parts of calcium silicate, 4 parts of nano-titanium oxide, 4 parts of medical stone powder, 6 parts of potassium metaphosphate and 3 parts of nano-tungsten oxide.

[0047] Prepare tricalcium phosphate / zirconia bioceramics according to the preparation method provided by the invention, the steps are as follows:

[0048] (1) Weighing: Accurately weigh each component;

[0049] (2) Ball milling: Mix the components together and put them into a ball mill for grinding and mixing;

[0050] (3) Cold press forming: the mixed powder is pressed with a 60T press;

[0051] (4) Put the formed powder into the mold and perform high-temperature calcination at a temperature of 1200°C and a pressure of 580MPa for 6 hours;

[0052] (5) After calcination, take it out after cooling to obtain block tricalcium phosphate / zirconia b...

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Abstract

The invention discloses a tertiary calcium phosphate / zirconia bioceramic and a preparation method thereof, and relates to the field of biomaterials. The bioceramic is prepared from the following ingredients in parts by weight: 40-60 parts of tertiary calcium phosphate, 20-40 parts of zirconia, 5-15 parts of calcium silicate, 3-6 parts of nano titanium oxide, 3-6 parts of medical stone powder, 4-9 parts of potassium metaphosphate and 2-5 parts of nano tungsten oxide. The preparation method comprises the following steps: (1) weighing; (2) ball milling; (3) cold press molding; (4) high-temperature calcining; (5) cooling. The bioceramic is better in biocompatibility and higher in biological activity, meanwhile has excellent compressive strength and fracture tenacity, and is an ideal bone renovating and substitute material.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a tricalcium phosphate / zirconia bioceramic and a preparation method of the bioceramic. Background technique [0002] With the development of material science and technology, biomaterials have become one of the important research directions in the field of biomedicine because of their special properties of repairing, replacing and regenerating body tissues. Biological hard tissue substitute materials were first used body bones and animal bones, and later developed to use stainless steel and plastics. Due to the problems of dissolution, corrosion and fatigue of stainless steel, plastics have problems of poor stability and low strength. Therefore, the bottleneck in the development of biomaterials is caused. The emergence of bioceramics has improved the shortage of existing alternative materials. Because of its many advantages, bioceramics has broad development prospects. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622A61L27/12A61L27/02A61L27/54
CPCA61L27/10A61L27/12A61L27/50A61L2300/112A61L2300/404A61L2300/41A61L2300/412A61L2430/02C04B35/447C04B35/622C04B2235/3232C04B2235/3244C04B2235/3258C04B2235/3427C04B2235/3436C04B2235/3454C04B2235/3463C04B2235/447C04B2235/96
Inventor 李永超郭玉芹刘乐峰
Owner 江苏瀚仁生物科技有限公司
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