A kind of preparation method of h7n9 recombinant influenza virus inactivated vaccine

A technology for influenza virus and inactivated vaccines, which is applied in the field of preparation of H7N9 recombinant influenza virus inactivated vaccines, can solve the problems of multi-epitope mucosal immunization vaccines without good curative effect, and achieve great application value, strong immunogenicity and low cost low effect
CN104826099BActive Publication Date: 2019-04-19ZHAOQING DAHUANONG BIOLOGIC PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHAOQING DAHUANONG BIOLOGIC PHARMA
Publication Date
2019-04-19

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Abstract

The invention discloses a preparation method of an inactivated H7N9 recombinant influenza virus vaccine. The steps include the establishment of batch virus seeds of avian influenza working seeds; virus inoculation and cultivation; virus inactivation; virus harvest liquid filtration and concentration; virus purification; sugar removal; It is prepared as a semi-finished product of H7N9 avian influenza virus inactivated vaccine. The H7N9 recombinant influenza inactivated vaccine prepared according to the method of the invention has strong immunogenicity, broad antigen spectrum, stable quality, high purity, good safety, low cost, is suitable for large-scale production, and has great application value.
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Description

technical field

[0001] The invention belongs to the field of vaccine preparation, and in particular relates to a preparation method of H7N9 recombinant influenza virus inactivated vaccine. Background technique

[0002] Influenza is the abbreviation of influenza. It is a zoonotic infectious disease caused by influenza virus. The main symptoms after human infection are high fever, cough, runny nose, myalgia, etc. Most of them are accompanied by severe pneumonia. The failure of various organs such as kidneys and kidneys leads to death, and the case fatality rate is very high; the H7N9 subtype influenza that has occurred since April 2013 has posed a huge threat to humans and poultry. At present, vaccines are mainly used for prevention, and the vaccines used include virus inactivated vaccines, attenuated vaccines, and recombinant subunit vaccines.

[0003] The outer membrane of influenza virus particles is covered by two types of surface glycoproteins, one type is hemagglutinin ...

Claims

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