An external film-coating agent for treating fungal infectious skin diseases of cattle and sheep

A technology for fungal infection and film coating, which is used in skin diseases, antifungal agents, medical preparations containing active ingredients, etc. the effect of extinction

Active Publication Date: 2017-10-27
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Terbinaphol hydrochloride (CAS No.: 78628-80-5) is an allylamine antifungal drug that has been released since the 1990s. In veterinary clinics, its oral preparations have been applied to fungal skin diseases in dogs and cats, but Adverse effects such as liver damage, loss of taste, pancytopenia, thrombocytopenia, agranulocytosis, renal dysfunction, and parotid gland enlargement have been reported in the treatment of dermatophytosis in dogs and cats by oral administration of terbinafine hydrochloride. reaction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: A kind of external coating agent for the treatment of fungal infectious skin diseases of cattle and sheep

[0037] Povidone 10g

[0038] Terbinaol Hydrochloride 5g

[0039] borneol 3g

[0040] Polyethylene glycol-12-hydroxystearate 25mL

[0041] Azone 2 mL

[0042] Glycerin 3 mL

[0043] Preparation: (1) Add povidone, polyethylene glycol-12-hydroxystearate (melted into liquid in a water bath in advance), azone and glycerin according to the amount, add an appropriate amount of water for injection and mix until the solution is clear and transparent. Liquid Ⅰ; (2) Add terbinaphol hydrochloride and borneol to 30mL ethanol according to the amount, mix and stir until the solution is colorless and clear, and become liquid Ⅱ; (3) Combine liquid Ⅰ and liquid Ⅱ and mix well, and use injection if it is less than 100mL Make up to 100mL with water; aseptically fill in dry polyethylene bottles, seal with thermoplastic, cover with a sterilized cap, pack, and deliver...

Embodiment 2

[0045] Compared with Example 1, only the prescription amount of terbinaphthol hydrochloride is changed to 1g, and the external coating film preparation for the qualified treatment of bovine and sheep fungal infectious skin diseases is prepared.

Embodiment 3

[0047] Compared with Example 1, only the prescription amount of terbinaphthol hydrochloride was changed to 3g, and a qualified external coating for the treatment of cattle and sheep fungal infectious skin diseases was prepared.

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PUM

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Abstract

The invention discloses an externally-used film coating agent for treating fungal infection type dermatosis attacking cattle and sheep. The film coating agent comprises raw materials in percentage by weight as follows: 35%-65% of a film-forming agent, 1%-5% of terbinafine hydrochloride, 1%-3% of borneol, 2%-3% of a penetrating agent, 3%-5% of a plasticizer and the balance of a solvent. The externally-used film coating agent for treating fungal infection type dermatosis attacking cattle and sheep has a good treatment effect on fungal infection type dermatosis attacking cattle and sheep, has a long lasting period, does irritate the skin and is safe and reliable.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to an external coating agent for treating fungal infectious skin diseases of cattle and sheep. Background technique [0002] The fungal dermatosis of cattle and sheep is clinically called ringworm in cattle and sheep. It is caused by the infection of the hair of cattle wool and the cuticle of the skin by Trichophyton ringworm (occasionally seen with Trichophyton). , is a skin fungal disease caused by dermatophytes infecting the epidermis and its subsidiary structures; this disease is common and frequently occurs in cattle and sheep breeding, especially when the feeding conditions are poor, the feeding environment changes or the nutritional status is poor , and even cause explosive infection. The common feature of this disease is that off-white or yellow scales and ringworm spots appear on the surface of the skin, hair loss, skin thickening, and sick animals are accompa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/137A61P31/10A61P17/00A61K31/045
Inventor 周绪正张继瑜李冰魏小娟牛建荣程富胜王娟娟李剑勇杨亚军刘希望王玲
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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