Chitosan spraying film agent and preparation method thereof

Abstract

The invention provides a chitosan spraying film agent. The chitosan spraying film agent is prepared from the following components in percentage by weight: 0.05% to 0.5% of chitosan, 0.01% to 0.15% of lactic acid, 0.1% to 0.2% of a surfactant, 0.1% to 0.3% of a cosolvent and the balance of water. The invention further provides a method for preparing the spraying film agent and application of the spraying film agent. The prepared chitosan spraying film agent provided by the invention is little in irritation for skin wounds, and high in film-forming property, biological availability and antibacterial ability, and can effectively promote wound healing.

Description

technical field [0001] The invention relates to a chitosan spray film agent and a preparation method thereof, belonging to the field of medicines. Background technique [0002] With the development of industrialization in the world, trauma has become a common disease in daily life, and trauma infection is an important cause of death. According to the statistics of the World Health Organization, in 1990, the number of deaths from various traumas in the world was about 5.1 million, and it is expected to increase to 8.4 million in 2020. Trauma is a kind of disease that cannot be ignored, so it is very necessary to carry out research on the treatment and repair of trauma. With the development of the "moist healing" theory of wound repair by Winter, Hinman and Maibaeh, etc., the application of wound repair and protective materials and accessories has gradually developed. [0003] Antibiotic drug dressings are widely used clinically for antibacterial treatment of skin wounds. Ho...

AI Technical Summary

Problems solved by technology

High-molecular-weight chitosan has the advantages of good film-forming properties and strong antibacterial ability, but because of its high crystallinity and poor solubility, it cannot be prepared, and its application is greatly limited; low-molecular-weight chitosan or chitosan derivatives It needs to be prepared by degradation and derivatization methods. Although its solubility problem has been improved, its film-forming and antibacterial capabilities have declined

[0005] At present, commercially available and chitosan products reported in the literature all use low molecular weight chitosan (such as CN102846655A, CN104042719A, CN102824308) or chitosan derivatives (such as CN104586753A) as active ingredients, although its solubility is better, However, the antibacterial ability is not good, and it is necessary to use a large dose of active ingredients or add a variety of antibacterial active substances to play a synergistic effect in order to achieve a better antibacterial effect

This will lead to disadvantages such as excessive consumption of raw and auxiliary materials of the preparation, complicated preparation process, increased production cost, and adverse effects on the quality and safety of the preparation.

[0006] At the same time, in order to dissolve chitosan well, chitosan products currently use a solvent with better solubility: acetic acid, but it has strong irritation, which directly affects the safety of medication.

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