Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof

A technology of lanthanum methylcantharidin amidate and methylcantharidin amidate, which is applied in the field of N-pyridine-desmethylcantharidin amidate lanthanum amidate complexes and its preparation, to achieve good selective activity, easy reaction, and low toxic effect

Inactive Publication Date: 2015-09-02
沈丹
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the certain physiological toxicity of rare earth materials, it is necessary to overcome the physiological toxicity when directly applied to medicine.
[0007] Through searching, at present, there is no literature at home and abroad to improve demethylcantharidin in the direction of combining amide group, rare earth and demethylcantharidin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof
  • N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof
  • N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] 1.1 Instrument

[0030] Vario EL III elemental analyzer for elemental analysis

[0031] NEXUS-670 Fourier Transform Infrared Spectrometer for Infrared Spectrum Analysis

[0032] TGA / SDTA851 for thermogravimetric analysis e type thermal analyzer

[0033] UV-2501PC UV-Vis Photometer for UV Spectrum Analysis

[0034] DDS-12 Digital Conductivity Meter for Molar Conductance

[0035] Bruker Avanze 400MHz NMR instrument for proton NMR analysis

[0036] PHS-3C acidity meter

[0037] R201D-II rotary evaporator

[0038] Melting point apparatus: Shanghai Precision Scientific Instrument Co., Ltd. WRS-1B digital melting point apparatus

[0039] 1.2 Reagents

[0040] Demethylcantharidin (Sinopharm Group, chemically pure.); 2-aminopyridine (Sinopharm Chemical Reagent Co., Ltd. Chemically pure); rare earth oxide M 2 o 3 (content > 99.9%, China Pharmaceutical Group Shanghai Chemical Reagent Company); lanthanum La (NO 3 ) 3 ·nH 2 O; acetonitrile; absolute ethanol; methanol; ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and a preparation method thereof. The chemical formula of the N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex is [Ln(HL1)(NO3)(H2O)2](NO3).2H2O, wherein Ln represents lanthanum; and HL1 represents an N-pyridine-demethyl cantharidin amic acid ligand. The synthesized N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex synthetized by the application has relatively high physiological activity and antioxidant stability.

Description

Technical field [0001] The present invention is a chemical synthesis technology field, which specifically refers to a N-pyridine-dexyedaminaminamide (III) cricket and its preparation method. Background technique [0002] Cantharidin (CA) is a kind of natural defensive toxin widely existed in more than 1,500 crickets.Paea lotus is a green family insect. It is cold and cold. It is a toxic Chinese medicinal material. In addition to anti -cancer activity, there are various actives such as antiviral, aphrodisiac, and elevation of white blood cells.Clinically, cashmecin shows its unique curative effect in treating cancer and some incurable diseases.However, due to the high toxicity and substantial damage to the heart and kidney organs, it has greatly restricted the application of spotcin in the application. Therefore, the design synthesis of some selective inhibitory inhibitory of tumor cells, small toxicity, and no effect on the body's immune response has no effect.Derivatives are of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61P35/00
Inventor 沈丹陈洁
Owner 沈丹
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com