N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof

A technology of lanthanum methylcantharidin amidate and methylcantharidin amidate, which is applied in the field of N-pyridine-desmethylcantharidin amidate lanthanum amidate complexes and its preparation, to achieve good selective activity, easy reaction, and low toxic effect

Inactive Publication Date: 2015-09-02
沈丹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the certain physiological toxicity of rare earth materials, it is necessary to overcome the physiological toxicity when directly applied to medicine.
[0007] Through searching, at present, there is no literature at home and abroad to improve demethylcantharidin in the direction of combining amide group, rare earth and demethylcantharidin

Method used

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  • N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof
  • N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof
  • N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and preparation method thereof

Examples

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Embodiment

[0029] 1.1 Instrument

[0030] Vario EL III elemental analyzer for elemental analysis

[0031] NEXUS-670 Fourier Transform Infrared Spectrometer for Infrared Spectrum Analysis

[0032] TGA / SDTA851 for thermogravimetric analysis e type thermal analyzer

[0033] UV-2501PC UV-Vis Photometer for UV Spectrum Analysis

[0034] DDS-12 Digital Conductivity Meter for Molar Conductance

[0035] Bruker Avanze 400MHz NMR instrument for proton NMR analysis

[0036] PHS-3C acidity meter

[0037] R201D-II rotary evaporator

[0038] Melting point apparatus: Shanghai Precision Scientific Instrument Co., Ltd. WRS-1B digital melting point apparatus

[0039] 1.2 Reagents

[0040] Demethylcantharidin (Sinopharm Group, chemically pure.); 2-aminopyridine (Sinopharm Chemical Reagent Co., Ltd. Chemically pure); rare earth oxide M 2 o 3 (content > 99.9%, China Pharmaceutical Group Shanghai Chemical Reagent Company); lanthanum La (NO 3 ) 3 ·nH 2 O; acetonitrile; absolute ethanol; methanol; ...

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Abstract

The invention discloses an N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex and a preparation method thereof. The chemical formula of the N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex is [Ln(HL1)(NO3)(H2O)2](NO3).2H2O, wherein Ln represents lanthanum; and HL1 represents an N-pyridine-demethyl cantharidin amic acid ligand. The synthesized N-pyridine-demethyl cantharidin amic acid lanthanum (III) complex synthetized by the application has relatively high physiological activity and antioxidant stability.

Description

Technical field [0001] The present invention is a chemical synthesis technology field, which specifically refers to a N-pyridine-dexyedaminaminamide (III) cricket and its preparation method. Background technique [0002] Cantharidin (CA) is a kind of natural defensive toxin widely existed in more than 1,500 crickets.Paea lotus is a green family insect. It is cold and cold. It is a toxic Chinese medicinal material. In addition to anti -cancer activity, there are various actives such as antiviral, aphrodisiac, and elevation of white blood cells.Clinically, cashmecin shows its unique curative effect in treating cancer and some incurable diseases.However, due to the high toxicity and substantial damage to the heart and kidney organs, it has greatly restricted the application of spotcin in the application. Therefore, the design synthesis of some selective inhibitory inhibitory of tumor cells, small toxicity, and no effect on the body's immune response has no effect.Derivatives are of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61P35/00
Inventor 沈丹陈洁
Owner 沈丹
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