Protein of acinetobacter baumannii hypothetical protein A1S_1523 as well as preparation method and application of protein

A technology of Acinetobacter baumannii and protein, which is applied in the biological field to achieve good immune protection effect, controllable quality and safety, and simple steps
CN104877019AActive Publication Date: 2015-09-02ARMY MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ARMY MEDICAL UNIV
Publication Date
2015-09-02

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Abstract

The invention relates to recombinant protein of A1S_1523 as well as a preparation method and application of the recombinant protein. The recombinant protein comprises A1S_1523 mature peptide, and an amino acid sequence of the recombinant protein is shown in SEQ ID NO. 3. The recombinant protein disclosed by the invention is high in expression quantity and convenient to separate and purify, is efficient and safe, can be directly matched with adjuvants for use, and can be used for preparing acinetobacter baumannii infection resistant subunit vaccines and related detection kits; proven by animal experiments, gene engineering recombinant monovalent subunit vaccines have good immune protective effects on acinetobacter baumannii infection resistance; and the recombinant protein can be used for laying a foundation for further researching combined vaccines and multi-subunit fusion vaccines, and can also play important roles in the development and application of prevention and treatment vaccines and diagnostic kits.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a hypothetical protein A1S_1523 of Acinetobacter baumannii and its preparation method and application. Background technique

[0002] Acinetobacter baumannii (Acinetobacter baumanni i) is a common non-fermenting gram-negative bacillus that exists widely in nature and can normally colonize the surface of human skin and in the cavity. It is an opportunistic pathogen that can mainly cause pneumonia, Bloodstream infection, skin and soft tissue infection, endocarditis, meningitis, etc. With the increasing detection rate of its drug-resistant strains year by year, Acinetobacter baumannii has become an important pathogenic bacteria in the world. Among the strains of Acinetobacter baumannii isolated from various nosocomial infections, multi-drug resistant (MDR) strains accounted for 65%. my country's CHINET antimicrobial resistance monitoring network data show that in 14 teaching hospitals ...

Claims

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