Method for determining content of bismuth in colloidal bismuth pectin or preparation containing colloidal bismuth pectin

A technology of colloidal bismuth pectin and a determination method, which is applied in the direction of material analysis, biological testing, and measuring devices through observation of the impact on chemical indicators, can solve problems such as difficult to use and determine the content of colloidal bismuth pectin and bismuth, and achieve High accuracy, good linear relationship and good repeatability

Active Publication Date: 2015-09-02
SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the complexometric titration method has been used for many years, and it is difficult to use simple and accurate spectrophotometry to determine the content of bismuth in colloidal bismuth pectin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Colloidal bismuth pectin.

[0024] 1) Preparation of chromogenic solution: Take 5g of ascorbic acid and 25g of potassium iodide, put them in a 200ml volumetric flask, add 100ml of water, shake to dissolve, add 25ml of 1mol / L nitric acid solution, dilute with water and set the volume to the mark to make 2.5% ascorbic acid , Potassium iodide 12.5% ​​chromogenic solution.

[0025] 2) Preparation of bismuth reference substance solution: Take 275 mg of bismuth metal, accurately weigh it, put it in a 100 ml volumetric flask, add 6.4 ml of nitric acid to dissolve, dilute with water to the mark, and use it as a bismuth standard stock solution. Precisely measure 2ml of bismuth standard stock solution, put it in a 100ml volumetric flask, dilute to the mark with 1mol / L nitric acid solution, and make a solution containing about 55μg of bismuth per 1ml, as the bismuth standard solution. Precisely measure 5ml of bismuth standard solution, put it in a 25ml volumetric flask...

Embodiment 2

[0029] Embodiment 2: Colloidal bismuth pectin capsules (40 mg, calculated as bismuth).

[0030] 1) Preparation of chromogenic solution: Take 2.5g of ascorbic acid and 12.5g of potassium iodide, put them in a 200ml volumetric flask, add 100ml of water, shake to dissolve, add 25ml of 1mol / L nitric acid solution, dilute with water and set the volume to the mark to make ascorbic acid-containing solution 1.25%, potassium iodide 6.25% color solution.

[0031] 2) Preparation of bismuth reference solution: Take 250 mg of bismuth metal, accurately weigh it, put it in a 100 ml volumetric flask, add 6.4 ml of nitric acid to dissolve, dilute with water to the mark, and use it as a bismuth standard stock solution. Accurately measure 1ml of bismuth standard stock solution, put it in a 10ml volumetric flask, dilute to the mark with 1.2mol / L nitric acid solution, and make a solution containing about 250μg of bismuth per 1ml, as the bismuth standard solution. Precisely measure 5ml of bismuth ...

Embodiment 3

[0035] Embodiment 3: colloidal bismuth pectin capsules (specification 50 mg, calculated as bismuth).

[0036] 1) Preparation of chromogenic solution: Take 10g of ascorbic acid and 50g of potassium iodide, put them in a 200ml volumetric flask, add 100ml of water, shake to dissolve, add 25ml of 1mol / L nitric acid solution, dilute with water and set the volume to the mark to make 5% ascorbic acid , Potassium iodide 25% chromogenic solution.

[0037] 2) Preparation of bismuth reference substance solution: Take 500 mg of bismuth metal, accurately weigh it, put it in a 100 ml volumetric flask, add 6.4 ml of nitric acid to dissolve, dilute to the mark with water, and use it as a bismuth standard stock solution. Precisely measure 1ml of bismuth standard stock solution, put it in a 100ml volumetric flask, dilute to the mark with 0.8mol / L hydrochloric acid solution, and make a solution containing about 50μg of bismuth per 1ml, as the bismuth standard solution. Precisely measure 5ml of ...

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PUM

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Abstract

The invention provides a method for determining the content of bismuth in colloidal bismuth pectin or a preparation containing the colloidal bismuth pectin. According to the method, the bismuth is dissociated from the colloidal bismuth pectin with protonic acid, the characteristic reaction principle that bismuth reacts with potassium iodide to generate yellow bismuth potassium iodide is used, ultraviolet-visible spectrophotometry is adopted for determining, and the content is calculated through an external standard method. The established method for determining the content of the bismuth in the colloidal bismuth pectin or the preparation containing the colloidal bismuth pectin is high in specificity, good in linearity, high in accuracy, repeatability and sensitivity and capable of serving as a quality control method for the bismuth in the colloidal bismuth pectin or the preparation containing the colloidal bismuth pectin to effectively control product quality.

Description

technical field [0001] The invention relates to a method for measuring bismuth content, in particular to a method for measuring bismuth content in macromolecule chelated bismuth-containing substances. Background technique [0002] Colloidal bismuth pectin is a compound of indeterminate composition formed by pectin and metal bismuth (Bi), yellow powder, containing 14.0%-16.0% pectin bismuth (calculated as bismuth), pH value 8.5-10.5, sedimentation Volume ratio 1-0.97, insoluble in organic solvents such as ethanol, acetone, ether, etc., can form a stable colloidal dispersion in water. [0003] Colloidal bismuth pectin replaces small molecular acid radicals with biomacromolecular pectin. Compared with other bismuth preparations such as bismuth subgallate, bismuth subnitrate, bismuth salicylate, and bismuth potassium citrate, the colloidal properties are stronger, The viscosity is higher, and the body absorbs less. Colloidal bismuth pectin has a strong affinity with the ulcer ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
CPCA61P1/04A61P31/04G01N21/33G01N21/78G01N33/84G01N2400/46
Inventor 李安平崔锋朱平秦正国郑台吴月侠
Owner SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
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