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Environment-friendly surface modification method for preparing hydrogel drug carrier

An environmentally friendly and surface modification technology, applied in the direction of inactive components of polymer compounds, can solve problems such as poor mechanical properties and cumbersome methods, and achieve great social and economic benefits.

Active Publication Date: 2015-09-09
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is cumbersome, and some mechanical properties of cyclodextrin-containing copolymer hydrogels are not as good as traditional hydrogels.

Method used

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  • Environment-friendly surface modification method for preparing hydrogel drug carrier
  • Environment-friendly surface modification method for preparing hydrogel drug carrier
  • Environment-friendly surface modification method for preparing hydrogel drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 (pHEMA-CD1)

[0034] Put the prepared 0.3g pHEMA hydrogel sheets (diameter 1.5mm, thickness 150μm, 5 pieces) into the reaction vessel, add 10mL acetone, then add 650μL propyne bromide, then add 0.96g potassium carbonate as a catalyst, seal After 2 hours of magnetic stirring reaction, the hydrogel sheet was taken out and put into water to terminate the reaction, and the unreacted monomer and catalyst were washed away with water and acetone to obtain an alkynylated hydrogel sheet. The grafting rate of alkynyl groups on the hydrogel was determined to be 10.13% by mass method.

[0035] Dissolve 268 mg of mono(6-mercapto-6-deoxy)-β-cyclodextrin (purchased directly) in 20 mL of a mixed solvent of tetrahydrofuran and water at a ratio of 1:1, and then dissolve 0.3 g of alkynylated The hydrogel sheet is placed in a solution containing cyclodextrin, and finally photoinitiator I2959 is added at a concentration of 0.1%. After stirring evenly, it is sealed, and then react...

Embodiment 2

[0036] Example 2 (pHEMA-CD2)

[0037] Put the prepared 0.3g pHEMA hydrogel sheets (diameter 1.5mm, thickness 150μm, 5 pieces) into the reaction vessel, add 10mL acetone, then add 650μL propyne bromide, then add 0.96g potassium carbonate as a catalyst, seal After 2 hours of magnetic stirring reaction, the hydrogel sheet was taken out and put into water to terminate the reaction, and the unreacted monomer and catalyst were washed away with water and acetone to obtain an alkynylated hydrogel sheet. The grafting rate of alkynyl groups on the hydrogel was determined to be 10.13% by mass method.

[0038] Dissolve 538 mg of mono(6-mercapto-6-deoxy)-β-cyclodextrin (purchased directly) in 20 mL of a mixed solvent of tetrahydrofuran and water at a ratio of 1:1, and then 0.3 g of the above alkyne The hydrogel sheet is placed in a solution containing cyclodextrin, and finally photoinitiator I2959 is added at a concentration of 0.1%. After stirring evenly, it is sealed, and then reacted u...

Embodiment 3

[0039] Example 3 (pHEMA-CD3)

[0040] Put the prepared 0.3g pHEMA hydrogel sheets (diameter 1.5mm, thickness 150μm, 5 pieces) into the reaction vessel, add 10mL acetone, then add 650μL propyne bromide, then add 0.96g potassium carbonate as a catalyst, seal After 2 hours of magnetic stirring reaction, the hydrogel sheet was taken out and put into water to terminate the reaction, and the unreacted monomer and catalyst were washed away with water and acetone to obtain an alkynylated hydrogel sheet. The grafting rate of alkynyl groups on the hydrogel was determined to be 10.13% by mass method.

[0041] Dissolve 1.34 g of mono(6-mercapto-6-deoxy)-β-cyclodextrin (purchased directly) in 20 mL of a mixed solvent of tetrahydrofuran and water at a ratio of 1:1, and then add the above 0.3 g of alkynyl Place the degraded hydrogel sheet in a cyclodextrin-containing solution, and finally add photoinitiator I2959 at a concentration of 0.1%, stir evenly and seal it, and react under sunlight ...

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Abstract

The invention discloses an environment-friendly surface modification method for preparing a hydrogel drug carrier. The method comprises the following steps that after a hydrogel sheet is mixed with propargyl bromide, catalysts are added, and a reaction is achieved by stirring under the sealed environment; after the reaction, the hydrogel sheet is taken out, monomers and the catalysts which have no reaction on the hydrogel sheet are washed out, and the hydrogel sheet is obtained after alkynylation; the hydrogel sheet obtained after alkynylation, mono-(6-sulfydryl-6-deoxidation)-beta-cyclodextrin and photoinitiators are evenly mixed and sealed, and are placed in the sun to react; after the reaction, the hydrogel sheet is taken out, the monomers and the catalysts which have no reaction on the hydrogel sheet are washed out, and the hydrogel sheet with a cyclodextrin function is obtained. According to the surface method for the hydrogel with the good drug control releasing capacity, the basic performance of the hydrogel is kept in the performance of the obtained product, and drug releasing can be controlled. Great social and economic benefits are achieved.

Description

technical field [0001] The invention belongs to the technical field of new materials, and relates to the preparation of contact lens surface coatings and the loading and release of drugs by multilayer films. Background technique [0002] Traditional hydrogels use initiators to initiate free radical copolymerization of monomers to form hydrogel networks. The research and application of hydrogel originated from the invention and use of soft contact lenses, which are polymerized from a series of monomers with hydroxyethyl methacrylate (HEMA) as the main chain. Common monomers of copolymerized hydrogel contact lenses include hydroxyethyl methacrylate (HEMA), vinylpyrrolidone (NVP), acrylamide (AA), methacrylic acid (MA) and other monomers. Among them, HEMA is used as the main chain of the hydrogel, and some other monomers are used as functional monomers to increase the hydrophilicity and oxygen permeability of the hydrogel. [0003] With the development of science and technolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40C08G81/02C08B37/16
Inventor 胡小红陈频王昕陈尚能
Owner JINLING INST OF TECH
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