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Selenized resveratrol preparation for treating cancers

一种白藜芦醇、硒化的技术，应用在有机化合物的制备、有机化学、羧酸盐制备等方向，能够解决效果有限、肿瘤抑制作用无效等问题，达到良好治疗效果、提高人体免疫力的效果

Inactive Publication Date: 2015-09-09
SHANGHAI AI QI ECOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, conventional resveratrol has been reported to be selective and of limited efficacy in the treatment of cancer
[See: Cancer-specific Therapeutic Potential of Resveratrol: Metabolic Approach against Hallmarks of Cancerhttp: / / functionalfoodscenter.net / files / 73514409.pdf. In addition, other studies have shown that although resveratrol has antitumor effect, the inhibitory effect on tumors may be ineffective in some animal models

Method used

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  • Selenized resveratrol preparation for treating cancers
  • Selenized resveratrol preparation for treating cancers
  • Selenized resveratrol preparation for treating cancers

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preparation example Construction

[0022] According to another preferred embodiment of the present invention, the preparation method of the trans-selenized resveratrol preparation with alkali metal ion selenium complex as functional group comprises the following steps:

[0023] A. react high-purity (≥99%) trans-resveratrol with at least one metal inorganic base to obtain stilbene triphenol hydroxy acid salt;

[0024] B. The obtained stilbene triphenol hydroxy acid salt and SeO 2 reaction to obtain the described selenized trans-resveratrol and selenized cis-resveratrol with the alkali metal ion selenium complex as the functional group, which is the high Selenium content Selenized trans-resveratrol compound preparation.

[0025] Preferably, in the commercial product of the selenized resveratrol compound preparation: selenized trans-resveratrol ≥ 80% (mass fraction), selenized resveratrol ≤ 8%, and another ≥ 10% high Pure Resveratrol (≥99%).

[0026] in,

[0027] The cis-resveratrol:

[0028] The selenized...

Embodiment 1

[0038] A. React high-purity (≥99%) trans-resveratrol with sodium hydroxide at least to obtain sodium stilbene triphenol hydroxyacid, wherein, trans-resveratrol: sodium hydroxide=1: 0.25 (mass ratio), the reaction temperature was controlled at 120°C, and the time was 180s to obtain the sodium salt of stilbene triphenol hydroxyacid group;

[0039] B. The sodium stilbene triphenol hydroxy acid base and SeO will be obtained 2 reaction to obtain the trans-selenized resveratrol preparation (mass fraction ≥ 80%) and the selenized cis-resveratrol preparation (≤ 8%) with the alkali metal ion selenium complex as the functional group, Among them, the sodium salt of stilbene triphenol hydroxy acid group: SeO 2 =1:0.35, the reaction temperature is controlled at 280°C, the time is 250s, and after cooling, the high selenium content selenized trans-resveratrol complex preparation with alkali metal ion selenium complex as the functional group is obtained.

[0040] Among them, in the ex-facto...

Embodiment 2

[0042] A. react high-purity (≥99%) trans-resveratrol with potassium hydroxide at least to obtain stilbene triphenol hydroxyacid potassium, wherein, trans-resveratrol: potassium hydroxide=1: 0.25 (mass ratio), the reaction temperature was controlled at 120°C, and the time was 180s to obtain the potassium salt of stilbene triphenol hydroxyacid;

[0043] B. The potassium stilbene triphenol hydroxy acid and SeO will be obtained 2 reaction to obtain the trans-selenized resveratrol preparation (mass fraction ≥ 80%) and the selenized cis-resveratrol preparation (≤ 8%) with the alkali metal ion selenium complex as the functional group, Among them, the potassium salt of stilbene triphenol hydroxy acid: SeO 2 =1:0.35 (mass ratio), the reaction temperature is controlled at 280°C, and the time is 250s. After cooling, the high-selenium content selenized trans-resveratrol compound preparation with the alkali metal ion selenium complex as the functional group is obtained. .

[0044] Among...

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Abstract

A trans-selenized resveratrol for treating cancers has a structure as shown by formula (I), wherein the hydroxy at positions 3, 4 and 5 can be substituted, and at least one of positions 3, 4 and 5 is substituted by R, wherein R is a selenium complex of an alkali metal ion, R = formula (II). The trans-selenized resveratrol preparation of the present invention has a general therapeutic effect on various cancers, such as lung cancer, lymphoma, gastric cancer, liver cancer, carcinoma of the small intestine, colorectal cancer and gynecological cancers, etc., and achieves a good therapeutic effect.

Description

technical field [0001] The invention relates to a medicine for treating cancer, in particular to a selenized resveratrol preparation with alkali metal ion selenium complex as a functional group for treating cancer. Background technique [0002] Cancer is a serious threat to human health and life. According to the statistics of the World Health Organization, about 5 million patients die of cancer every year in the world, and drug therapy is one of the effective treatments for cancer. A variety of drugs that have positive effects on cancer have been studied at present, but their therapeutic effects are not satisfactory, and there are still few drugs that have general therapeutic effects on various cancers. The development of drugs with good effects on cancer, especially a variety of cancers, has become a research hotspot and difficulty. [0003] Trans-resveratrol (higher in activity than cis-resveratrol) is a well-known functional polyphenol compound (mainly derived from gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C391/02A61K31/095A61P35/00
CPCA61K31/21A61P35/00C07C391/02A61K31/095C07C51/295
Inventor 陈躬宋昆元
Owner SHANGHAI AI QI ECOLOGICAL TECH