Sodium alginate microsphere vascular embolization agent and preparation method thereof

The technology of a vascular embolizing agent and sodium alginate is applied in the field of sodium alginate microsphere vascular embolizing agent and its preparation, which can solve the problems of tissue or organ embolism, wide product particle size distribution, uncontrollable size, etc., and reduce toxic and side effects. , Improve local efficacy and uniform particle size

Active Publication Date: 2015-09-16
ENERGY RES INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many sodium alginate microsphere vascular embolism agents on the market, but the products have problems such as wide particle size distribution and uncontrollable size. Embolism in other tissues or organs, especially microspheres with small particle size, can easily flow to the lungs through the blood, causing life-threatening pulmonary embolism
[0008] At present, there is no use of microfluidics to produce sodium alginate microspheres with uniform particle size and size controllable vascular embolism, and there is no precedent for in situ curing reaction at the position where microdroplets are formed.

Method used

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  • Sodium alginate microsphere vascular embolization agent and preparation method thereof
  • Sodium alginate microsphere vascular embolization agent and preparation method thereof
  • Sodium alginate microsphere vascular embolization agent and preparation method thereof

Examples

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Embodiment 1

[0036] This embodiment provides a sodium alginate microsphere vascular embolization agent, which is prepared by the following steps:

[0037] choose as figure 1 In the microfluidic device shown, the outlet diameter of the discrete phase channel is 150 microns, and the width of the continuous phase channel is 1000 microns; the concentration of the sodium alginate aqueous solution used is 4%, and the solidification solution is 10wt% chloride Calcium aqueous solution;

[0038] The sodium alginate aqueous solution and the solidification solution were pumped into the discrete phase channel at a constant flow rate of 0.3mL / h and 2mL / h, while paraffin oil was pumped into the continuous phase channel at a constant flow rate of 2mL / h; the droplets in the discrete phase Generated near the exit of the channel, while solidifying to form microspheres;

[0039] The microspheres were collected and left to stand at room temperature at 25°C for more than 30 minutes to obtain a white solid; the...

Embodiment 2

[0041] This embodiment provides a sodium alginate microsphere vascular embolization agent, which is prepared by the following steps:

[0042] choose as figure 1 In the microfluidic device shown, the outlet diameter of the discrete phase channel is 160 microns, and the width of the continuous phase channel is 1000 microns; the concentration of the sodium alginate aqueous solution used is 5%, and the solidification solution is 10 wt% chloride Calcium aqueous solution;

[0043] The sodium alginate aqueous solution and the solidification solution were pumped into the discrete phase channel at a constant flow rate of 0.2mL / h and 3mL / h, and soybean oil was pumped into the continuous phase channel at a constant flow rate of 4mL / h; the droplets in the discrete phase Generated near the exit of the channel, while solidifying to form microspheres;

[0044] Collect the microspheres and let them stand at room temperature at 25°C for more than 30 minutes to obtain a white solid; then filt...

Embodiment 3

[0046] This embodiment provides a sodium alginate microsphere vascular embolization agent, which is prepared by the following steps:

[0047] choose as figure 1 In the microfluidic device shown, the outlet diameter of the discrete phase channel is 190 microns, and the width of the continuous phase channel is 1000 microns; the concentration of the sodium alginate aqueous solution used is 1%, and the solidification solution is 10 wt% chloride Calcium aqueous solution;

[0048] The sodium alginate aqueous solution and the solidification solution were pumped into the discrete phase channel at a constant flow rate of 0.05mL / h and 0.4mL / h, while dodecane was pumped into the continuous phase channel at a constant flow rate of 6mL / h; Formed near the outlet of the discrete phase channel, and solidified to form microspheres at the same time;

[0049] Collect the microspheres and let them stand at room temperature at 25°C for more than 30 minutes to obtain a white solid; then filter to...

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Abstract

The invention provides a sodium alginate microsphere vascular embolization agent and a preparation method of the sodium alginate microsphere vascular embolization agent. The preparation method of the sodium alginate microsphere vascular embolization agent comprises the following steps: (1) mixing an emulgator with a solvent to prepare a continuous phase; and (2) taking a sodium alginate solution as a discrete phase, taking a calcium chloride solution as a solidification solution, introducing the continuous phase, the discrete phase and the solidification solution into a micro-fluidic device for reacting to prepare the sodium alginate microsphere vascular embolization agent, wherein the flow of the discrete phase is controlled to be 0.1-10mL / h; the flow of the solidification solution is controlled to be 0.1-10mL / h; the flow of the continuous phase is controlled to be 1-20mL / h. The invention also provides a sodium alginate microsphere vascular embolization agent prepared by the method. The sodium alginate microsphere vascular embolization agent is uniform in particle diameter and controllable in size, can be solidified in situ, and has an excellent development prospect.

Description

technical field [0001] The invention relates to a sodium alginate microsphere vascular embolism agent and a preparation method thereof, belonging to the technical field of microspheres. Background technique [0002] As the third major diagnosis and treatment system in modern clinical therapeutics, interventional therapy has been recognized by the medical academic community and the majority of patients for its distinctive features of minimal invasiveness, accurate positioning, strong repeatability, low incidence of complications and high curative effect . Embolization therapy is an important technique of interventional therapy. Although the concept of vascular interventional embolization was proposed very early, it was not until the 1870s that it gradually entered people's field of vision with the development and application of medical imaging equipment, catheter technology, and embolic agents. Get people's real attention. [0003] Transcatheter embolization (TAE) is one of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/734A61K33/14A61P35/00
Inventor 王立秋李艳王建梅许敏孔湉湉
Owner ENERGY RES INST OF SHANDONG ACAD OF SCI
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